Early Impact of COVID-19 Outbreak on the Availability of Cornea Donors: Warnings and Recommendations

Mario Toro,1,2 Tomasz Choragiewicz,1 Chiara Posarelli,3 Michele Figus,3 Robert Rejdak1 On Behalf of European COVID-19 Cataract Group (#EUROCOVCAT)1Department of General Ophthalmology, Medical University of Lublin, Lublin, Poland; 2Faculty of Medical Sciences, Collegium Medicum Cardinal Stefan Wyszyń...

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Autores principales:	Toro M, Choragiewicz T, Posarelli C, Figus M, Rejdak R
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2020
Materias:	covid-19 pandemic keratoplasty transplant ophthalmology rt-pcr blood test chest ct scan. Ophthalmology RE1-994
Acceso en línea:	https://doaj.org/article/553bd337a19e4400b5a5dea3454fb327
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spelling	oai:doaj.org-article:553bd337a19e4400b5a5dea3454fb3272021-12-02T10:30:22ZEarly Impact of COVID-19 Outbreak on the Availability of Cornea Donors: Warnings and Recommendations1177-5483https://doaj.org/article/553bd337a19e4400b5a5dea3454fb3272020-09-01T00:00:00Zhttps://www.dovepress.com/early-impact-of-covid-19-outbreak-on-the-availability-of-cornea-donors-peer-reviewed-article-OPTHhttps://doaj.org/toc/1177-5483Mario Toro,1,2 Tomasz Choragiewicz,1 Chiara Posarelli,3 Michele Figus,3 Robert Rejdak1 On Behalf of European COVID-19 Cataract Group (#EUROCOVCAT)1Department of General Ophthalmology, Medical University of Lublin, Lublin, Poland; 2Faculty of Medical Sciences, Collegium Medicum Cardinal Stefan Wyszyński University, Warsaw, Poland; 3Department of Surgical, Medical, and Molecular Pathology, and of the Critical Area, University of Pisa, Pisa, ItalyCorrespondence: Mario ToroDepartment of General Ophthalmology, Medical University of Lublin, Lublin, PolandTel +48 608047052Fax +48 815326149Email toro.mario@email.itAbstract: Keratoplasty is one of the irreplaceable treatment options for corneal diseases. Currently, there is no evidence to substantiate that harvested corneal grafts from COVID-19 patients can contain SARS-CoV-2 virus and lead to a systemic infection. Although the risk of transmission through corneal stromal tissue is low, it potentially exists. Lack of clinical data, unclear potential of donor-derived infection and non-established recommendations for transplantation during the COVID-19 pandemic have resulted in a dramatic reduction in the number of keratoplasty and cornea donors at ophthalmology departments and eye banks. To eliminate the risk of infection of recipients and medical personnel, we suggest that the blood samples of all donors should be screened with RT-PCR tests and nasopharyngeal swabs should be taken. In addition, a chest CT scan should be performed if the circulation is maintained. Moreover, the donors’ clinical and epidemiological medical history must be screened for typical symptoms and potential contact with SARS-CoV-2 carriers to reduce the risk of transmission. The Guidelines of the Eye Bank Association of America (EBAA), Global Alliance of Eye Bank Associations (GAEBA) and European Association of Tissue Banks provide useful recommendations to eliminate the risk of transmission according to previous experiences based on similar viruses.Keywords: COVID-19 pandemic, keratoplasty, transplant, ophthalmology, RT-PCR blood test, chest CT scanToro MChoragiewicz TPosarelli CFigus MRejdak RDove Medical Pressarticlecovid-19 pandemickeratoplastytransplantophthalmologyrt-pcr blood testchest ct scan.OphthalmologyRE1-994ENClinical Ophthalmology, Vol Volume 14, Pp 2879-2882 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	covid-19 pandemic keratoplasty transplant ophthalmology rt-pcr blood test chest ct scan. Ophthalmology RE1-994
spellingShingle	covid-19 pandemic keratoplasty transplant ophthalmology rt-pcr blood test chest ct scan. Ophthalmology RE1-994 Toro M Choragiewicz T Posarelli C Figus M Rejdak R Early Impact of COVID-19 Outbreak on the Availability of Cornea Donors: Warnings and Recommendations
description	Mario Toro,1,2 Tomasz Choragiewicz,1 Chiara Posarelli,3 Michele Figus,3 Robert Rejdak1 On Behalf of European COVID-19 Cataract Group (#EUROCOVCAT)1Department of General Ophthalmology, Medical University of Lublin, Lublin, Poland; 2Faculty of Medical Sciences, Collegium Medicum Cardinal Stefan Wyszyński University, Warsaw, Poland; 3Department of Surgical, Medical, and Molecular Pathology, and of the Critical Area, University of Pisa, Pisa, ItalyCorrespondence: Mario ToroDepartment of General Ophthalmology, Medical University of Lublin, Lublin, PolandTel +48 608047052Fax +48 815326149Email toro.mario@email.itAbstract: Keratoplasty is one of the irreplaceable treatment options for corneal diseases. Currently, there is no evidence to substantiate that harvested corneal grafts from COVID-19 patients can contain SARS-CoV-2 virus and lead to a systemic infection. Although the risk of transmission through corneal stromal tissue is low, it potentially exists. Lack of clinical data, unclear potential of donor-derived infection and non-established recommendations for transplantation during the COVID-19 pandemic have resulted in a dramatic reduction in the number of keratoplasty and cornea donors at ophthalmology departments and eye banks. To eliminate the risk of infection of recipients and medical personnel, we suggest that the blood samples of all donors should be screened with RT-PCR tests and nasopharyngeal swabs should be taken. In addition, a chest CT scan should be performed if the circulation is maintained. Moreover, the donors’ clinical and epidemiological medical history must be screened for typical symptoms and potential contact with SARS-CoV-2 carriers to reduce the risk of transmission. The Guidelines of the Eye Bank Association of America (EBAA), Global Alliance of Eye Bank Associations (GAEBA) and European Association of Tissue Banks provide useful recommendations to eliminate the risk of transmission according to previous experiences based on similar viruses.Keywords: COVID-19 pandemic, keratoplasty, transplant, ophthalmology, RT-PCR blood test, chest CT scan
format	article
author	Toro M Choragiewicz T Posarelli C Figus M Rejdak R
author_facet	Toro M Choragiewicz T Posarelli C Figus M Rejdak R
author_sort	Toro M
title	Early Impact of COVID-19 Outbreak on the Availability of Cornea Donors: Warnings and Recommendations
title_short	Early Impact of COVID-19 Outbreak on the Availability of Cornea Donors: Warnings and Recommendations
title_full	Early Impact of COVID-19 Outbreak on the Availability of Cornea Donors: Warnings and Recommendations
title_fullStr	Early Impact of COVID-19 Outbreak on the Availability of Cornea Donors: Warnings and Recommendations
title_full_unstemmed	Early Impact of COVID-19 Outbreak on the Availability of Cornea Donors: Warnings and Recommendations
title_sort	early impact of covid-19 outbreak on the availability of cornea donors: warnings and recommendations
publisher	Dove Medical Press
publishDate	2020
url	https://doaj.org/article/553bd337a19e4400b5a5dea3454fb327
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Early Impact of COVID-19 Outbreak on the Availability of Cornea Donors: Warnings and Recommendations

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