Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain

In order to advance our understanding of the regulation of Ubiquitin-specific protease 8 (USP8), which is known to play a role in Cushing’s Disease, Kakihara et al identify and characterise amino acids 645–684 of USP8, which serve as an autoinhibitory region. Their pull-down and single-molecule FRET...

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Auteurs principaux:	Keijun Kakihara, Kengo Asamizu, Kei Moritsugu, Masahide Kubo, Tetsuya Kitaguchi, Akinori Endo, Akinori Kidera, Mitsunori Ikeguchi, Akira Kato, Masayuki Komada, Toshiaki Fukushima
Format:	article
Langue:	EN
Publié:	Nature Portfolio 2021
Sujets:	Biology (General) QH301-705.5
Accès en ligne:	https://doaj.org/article/553ea530ebaf4496bc79a1fb2f40c32c
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spelling	oai:doaj.org-article:553ea530ebaf4496bc79a1fb2f40c32c2021-11-14T12:12:05ZMolecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain10.1038/s42003-021-02802-x2399-3642https://doaj.org/article/553ea530ebaf4496bc79a1fb2f40c32c2021-11-01T00:00:00Zhttps://doi.org/10.1038/s42003-021-02802-xhttps://doaj.org/toc/2399-3642In order to advance our understanding of the regulation of Ubiquitin-specific protease 8 (USP8), which is known to play a role in Cushing’s Disease, Kakihara et al identify and characterise amino acids 645–684 of USP8, which serve as an autoinhibitory region. Their pull-down and single-molecule FRET analysis, as well as in silico modelling, suggest that the release of USP8 autoinhibition may underlie Cushing’s disease.Keijun KakiharaKengo AsamizuKei MoritsuguMasahide KuboTetsuya KitaguchiAkinori EndoAkinori KideraMitsunori IkeguchiAkira KatoMasayuki KomadaToshiaki FukushimaNature PortfolioarticleBiology (General)QH301-705.5ENCommunications Biology, Vol 4, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Biology (General) QH301-705.5
spellingShingle	Biology (General) QH301-705.5 Keijun Kakihara Kengo Asamizu Kei Moritsugu Masahide Kubo Tetsuya Kitaguchi Akinori Endo Akinori Kidera Mitsunori Ikeguchi Akira Kato Masayuki Komada Toshiaki Fukushima Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain
description	In order to advance our understanding of the regulation of Ubiquitin-specific protease 8 (USP8), which is known to play a role in Cushing’s Disease, Kakihara et al identify and characterise amino acids 645–684 of USP8, which serve as an autoinhibitory region. Their pull-down and single-molecule FRET analysis, as well as in silico modelling, suggest that the release of USP8 autoinhibition may underlie Cushing’s disease.
format	article
author	Keijun Kakihara Kengo Asamizu Kei Moritsugu Masahide Kubo Tetsuya Kitaguchi Akinori Endo Akinori Kidera Mitsunori Ikeguchi Akira Kato Masayuki Komada Toshiaki Fukushima
author_facet	Keijun Kakihara Kengo Asamizu Kei Moritsugu Masahide Kubo Tetsuya Kitaguchi Akinori Endo Akinori Kidera Mitsunori Ikeguchi Akira Kato Masayuki Komada Toshiaki Fukushima
author_sort	Keijun Kakihara
title	Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain
title_short	Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain
title_full	Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain
title_fullStr	Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain
title_full_unstemmed	Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain
title_sort	molecular basis of ubiquitin-specific protease 8 autoinhibition by the ww-like domain
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/553ea530ebaf4496bc79a1fb2f40c32c
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_version_	1718429346026225664

Molecular basis of ubiquitin-specific protease 8 autoinhibition by the WW-like domain

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