A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity
Chalcone synthase is the first committed enzyme in the plant flavonoid biosynthesis pathway, yet shows low product specificity in vitro. Here Waki et al. show that chalcone isomerase-like proteins bind to and reduce the catalytic promiscuity of chalcone synthase, ensuring efficient flavonoid product...
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2020
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oai:doaj.org-article:5541d10d04a7449c85f7f67f85623bb12021-12-02T17:31:56ZA conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity10.1038/s41467-020-14558-92041-1723https://doaj.org/article/5541d10d04a7449c85f7f67f85623bb12020-02-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-14558-9https://doaj.org/toc/2041-1723Chalcone synthase is the first committed enzyme in the plant flavonoid biosynthesis pathway, yet shows low product specificity in vitro. Here Waki et al. show that chalcone isomerase-like proteins bind to and reduce the catalytic promiscuity of chalcone synthase, ensuring efficient flavonoid production in planta.Toshiyuki WakiRyo MamedaTakuya NakanoSayumi YamadaMiho TerashitaKeisuke ItoNatsuki TenmaYanbing LiNaoto FujinoKaichi UnoSatoshi YamashitaYuichi AokiKonstantin DenessioukYosuke KawaiSatoko SugawaraKazuki SaitoKeiko Yonekura-SakakibaraYasumasa MoritaAtsushi HoshinoSeiji TakahashiToru NakayamaNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-14 (2020) |
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| topic |
Science Q |
| spellingShingle |
Science Q Toshiyuki Waki Ryo Mameda Takuya Nakano Sayumi Yamada Miho Terashita Keisuke Ito Natsuki Tenma Yanbing Li Naoto Fujino Kaichi Uno Satoshi Yamashita Yuichi Aoki Konstantin Denessiouk Yosuke Kawai Satoko Sugawara Kazuki Saito Keiko Yonekura-Sakakibara Yasumasa Morita Atsushi Hoshino Seiji Takahashi Toru Nakayama A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity |
| description |
Chalcone synthase is the first committed enzyme in the plant flavonoid biosynthesis pathway, yet shows low product specificity in vitro. Here Waki et al. show that chalcone isomerase-like proteins bind to and reduce the catalytic promiscuity of chalcone synthase, ensuring efficient flavonoid production in planta. |
| format |
article |
| author |
Toshiyuki Waki Ryo Mameda Takuya Nakano Sayumi Yamada Miho Terashita Keisuke Ito Natsuki Tenma Yanbing Li Naoto Fujino Kaichi Uno Satoshi Yamashita Yuichi Aoki Konstantin Denessiouk Yosuke Kawai Satoko Sugawara Kazuki Saito Keiko Yonekura-Sakakibara Yasumasa Morita Atsushi Hoshino Seiji Takahashi Toru Nakayama |
| author_facet |
Toshiyuki Waki Ryo Mameda Takuya Nakano Sayumi Yamada Miho Terashita Keisuke Ito Natsuki Tenma Yanbing Li Naoto Fujino Kaichi Uno Satoshi Yamashita Yuichi Aoki Konstantin Denessiouk Yosuke Kawai Satoko Sugawara Kazuki Saito Keiko Yonekura-Sakakibara Yasumasa Morita Atsushi Hoshino Seiji Takahashi Toru Nakayama |
| author_sort |
Toshiyuki Waki |
| title |
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity |
| title_short |
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity |
| title_full |
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity |
| title_fullStr |
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity |
| title_full_unstemmed |
A conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity |
| title_sort |
conserved strategy of chalcone isomerase-like protein to rectify promiscuous chalcone synthase specificity |
| publisher |
Nature Portfolio |
| publishDate |
2020 |
| url |
https://doaj.org/article/5541d10d04a7449c85f7f67f85623bb1 |
| work_keys_str_mv |
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