Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells

H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of brea...

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Autores principales:	Christophe E. Redon, Zoe Schmal, Gargi Tewary, Adèle Mangelinck, Régis Courbeyrette, Jean-Yves Thuret, Mirit I. Aladjem, William M. Bonner, Claudia E. Rübe, Carl Mann
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	histone variant H2A.J luminal breast cancer luminal prostate cancer cancer biomarker <i>H2AFJ</i> H2AJ Genetics QH426-470
Acceso en línea:	https://doaj.org/article/55425fbdbbf947028af58aaa0d78030c
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id	oai:doaj.org-article:55425fbdbbf947028af58aaa0d78030c
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spelling	oai:doaj.org-article:55425fbdbbf947028af58aaa0d78030c2021-11-25T17:40:27ZHistone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells10.3390/genes121116652073-4425https://doaj.org/article/55425fbdbbf947028af58aaa0d78030c2021-10-01T00:00:00Zhttps://www.mdpi.com/2073-4425/12/11/1665https://doaj.org/toc/2073-4425H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and salivary glands. H2A.J was also highly expressed in many carcinoma cell lines and in particular, those derived from luminal breast and prostate cancer. H2A.J thus appears to be a novel marker for luminal epithelial cancers. Knocking-out the <i>H2AFJ</i> gene in T47D luminal breast cancer cells reduced the expression of several estrogen-responsive genes which may explain its putative tumorigenic role in luminal-B breast cancer.Christophe E. RedonZoe SchmalGargi TewaryAdèle MangelinckRégis CourbeyretteJean-Yves ThuretMirit I. AladjemWilliam M. BonnerClaudia E. RübeCarl MannMDPI AGarticlehistone variant H2A.Jluminal breast cancerluminal prostate cancercancer biomarker<i>H2AFJ</i>H2AJGeneticsQH426-470ENGenes, Vol 12, Iss 1665, p 1665 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	histone variant H2A.J luminal breast cancer luminal prostate cancer cancer biomarker <i>H2AFJ</i> H2AJ Genetics QH426-470
spellingShingle	histone variant H2A.J luminal breast cancer luminal prostate cancer cancer biomarker <i>H2AFJ</i> H2AJ Genetics QH426-470 Christophe E. Redon Zoe Schmal Gargi Tewary Adèle Mangelinck Régis Courbeyrette Jean-Yves Thuret Mirit I. Aladjem William M. Bonner Claudia E. Rübe Carl Mann Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
description	H2A.J is a poorly studied mammalian-specific variant of histone H2A. We used immunohistochemistry to study its localization in various human and mouse tissues. H2A.J showed cell-type specific expression with a striking enrichment in luminal epithelial cells of multiple glands including those of breast, prostate, pancreas, thyroid, stomach, and salivary glands. H2A.J was also highly expressed in many carcinoma cell lines and in particular, those derived from luminal breast and prostate cancer. H2A.J thus appears to be a novel marker for luminal epithelial cancers. Knocking-out the <i>H2AFJ</i> gene in T47D luminal breast cancer cells reduced the expression of several estrogen-responsive genes which may explain its putative tumorigenic role in luminal-B breast cancer.
format	article
author	Christophe E. Redon Zoe Schmal Gargi Tewary Adèle Mangelinck Régis Courbeyrette Jean-Yves Thuret Mirit I. Aladjem William M. Bonner Claudia E. Rübe Carl Mann
author_facet	Christophe E. Redon Zoe Schmal Gargi Tewary Adèle Mangelinck Régis Courbeyrette Jean-Yves Thuret Mirit I. Aladjem William M. Bonner Claudia E. Rübe Carl Mann
author_sort	Christophe E. Redon
title	Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
title_short	Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
title_full	Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
title_fullStr	Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
title_full_unstemmed	Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells
title_sort	histone variant h2a.j is enriched in luminal epithelial gland cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/55425fbdbbf947028af58aaa0d78030c
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Histone Variant H2A.J Is Enriched in Luminal Epithelial Gland Cells

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