Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses.

Over expression of wild type or a catalytically dead mutant of Sirtuin 6 does not influence NFκB responses.

SIRT6 is involved in inflammation, aging and metabolism potentially by modulating the functions of both NFκB and HIF1α. Since it is possible to make small molecule activators and inhibitors of Sirtuins we wished to establish biochemical and cellular assays both to assist in drug discovery efforts an...

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Autores principales: Rachel Grimley, Oxana Polyakova, Jessica Vamathevan, Joanne McKenary, Brian Hayes, Champa Patel, Janet Smith, Angela Bridges, Andrew Fosberry, Anshu Bhardwaja, Bernadette Mouzon, Chun-Wa Chung, Nathalie Barrett, Nicola Richmond, Sundip Modha, Roberto Solari
Formato: article
Lenguaje:EN
Publicado: Public Library of Science (PLoS) 2012
Materias:
Medicine
R
Science
Q
Acceso en línea:https://doaj.org/article/554910ddac3e4c48ab605416698c2ab9
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