Fundamental Biomaterial Considerations in the Development of a 3D Model Representative of Primary Open Angle Glaucoma

Glaucoma is a leading cause of irreversible blindness globally, with primary open angle glaucoma (POAG) being the most common subset. Raised intraocular pressure is an important risk factor for POAG and is caused by a reduction in aqueous humour (AqH) outflow due to dysfunctional cellular and matrix...

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Autores principales:	Hannah C. Lamont, Imran Masood, Liam M. Grover, Alicia J. El Haj, Lisa J. Hill
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	primary open angle glaucoma trabecular meshwork 3D in vitro models Schlemm’s canal mechanical properties biomaterials Technology T Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/55496ba8f1194385886090a6389473f9
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spelling	oai:doaj.org-article:55496ba8f1194385886090a6389473f92021-11-25T16:46:18ZFundamental Biomaterial Considerations in the Development of a 3D Model Representative of Primary Open Angle Glaucoma10.3390/bioengineering81101472306-5354https://doaj.org/article/55496ba8f1194385886090a6389473f92021-10-01T00:00:00Zhttps://www.mdpi.com/2306-5354/8/11/147https://doaj.org/toc/2306-5354Glaucoma is a leading cause of irreversible blindness globally, with primary open angle glaucoma (POAG) being the most common subset. Raised intraocular pressure is an important risk factor for POAG and is caused by a reduction in aqueous humour (AqH) outflow due to dysfunctional cellular and matrix dynamics in the eye’s main drainage site, the trabecular meshwork (TM) and Schlemm’s canal (SC). The TM/SC are highly specialised tissues that regulate AqH outflow; however, their exact mechanisms of AqH outflow control are still not fully understood. Emulating physiologically relevant 3D TM/S in vitro models poses challenges to accurately mimic the complex biophysical and biochemical cues that take place in healthy and glaucomatous TM/SC in vivo. With development of such models still in its infancy, there is a clear need for more well-defined approaches that will accurately contrast the two central regions that become dysfunctional in POAG; the juxtacanalicular tissue (JCT) region of the TM and inner wall endothelia of the Schlemm’s canal (eSC). This review will discuss the unique biological and biomechanical characteristics that are thought to influence AqH outflow and POAG progression. Further consideration into fundamental biomaterial attributes for the formation of a biomimetic POAG/AqH outflow model will also be explored for future success in pre-clinical drug discovery and disease translation.Hannah C. LamontImran MasoodLiam M. GroverAlicia J. El HajLisa J. HillMDPI AGarticleprimary open angle glaucomatrabecular meshwork3D in vitro modelsSchlemm’s canalmechanical propertiesbiomaterialsTechnologyTBiology (General)QH301-705.5ENBioengineering, Vol 8, Iss 147, p 147 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	primary open angle glaucoma trabecular meshwork 3D in vitro models Schlemm’s canal mechanical properties biomaterials Technology T Biology (General) QH301-705.5
spellingShingle	primary open angle glaucoma trabecular meshwork 3D in vitro models Schlemm’s canal mechanical properties biomaterials Technology T Biology (General) QH301-705.5 Hannah C. Lamont Imran Masood Liam M. Grover Alicia J. El Haj Lisa J. Hill Fundamental Biomaterial Considerations in the Development of a 3D Model Representative of Primary Open Angle Glaucoma
description	Glaucoma is a leading cause of irreversible blindness globally, with primary open angle glaucoma (POAG) being the most common subset. Raised intraocular pressure is an important risk factor for POAG and is caused by a reduction in aqueous humour (AqH) outflow due to dysfunctional cellular and matrix dynamics in the eye’s main drainage site, the trabecular meshwork (TM) and Schlemm’s canal (SC). The TM/SC are highly specialised tissues that regulate AqH outflow; however, their exact mechanisms of AqH outflow control are still not fully understood. Emulating physiologically relevant 3D TM/S in vitro models poses challenges to accurately mimic the complex biophysical and biochemical cues that take place in healthy and glaucomatous TM/SC in vivo. With development of such models still in its infancy, there is a clear need for more well-defined approaches that will accurately contrast the two central regions that become dysfunctional in POAG; the juxtacanalicular tissue (JCT) region of the TM and inner wall endothelia of the Schlemm’s canal (eSC). This review will discuss the unique biological and biomechanical characteristics that are thought to influence AqH outflow and POAG progression. Further consideration into fundamental biomaterial attributes for the formation of a biomimetic POAG/AqH outflow model will also be explored for future success in pre-clinical drug discovery and disease translation.
format	article
author	Hannah C. Lamont Imran Masood Liam M. Grover Alicia J. El Haj Lisa J. Hill
author_facet	Hannah C. Lamont Imran Masood Liam M. Grover Alicia J. El Haj Lisa J. Hill
author_sort	Hannah C. Lamont
title	Fundamental Biomaterial Considerations in the Development of a 3D Model Representative of Primary Open Angle Glaucoma
title_short	Fundamental Biomaterial Considerations in the Development of a 3D Model Representative of Primary Open Angle Glaucoma
title_full	Fundamental Biomaterial Considerations in the Development of a 3D Model Representative of Primary Open Angle Glaucoma
title_fullStr	Fundamental Biomaterial Considerations in the Development of a 3D Model Representative of Primary Open Angle Glaucoma
title_full_unstemmed	Fundamental Biomaterial Considerations in the Development of a 3D Model Representative of Primary Open Angle Glaucoma
title_sort	fundamental biomaterial considerations in the development of a 3d model representative of primary open angle glaucoma
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/55496ba8f1194385886090a6389473f9
work_keys_str_mv	AT hannahclamont fundamentalbiomaterialconsiderationsinthedevelopmentofa3dmodelrepresentativeofprimaryopenangleglaucoma AT imranmasood fundamentalbiomaterialconsiderationsinthedevelopmentofa3dmodelrepresentativeofprimaryopenangleglaucoma AT liammgrover fundamentalbiomaterialconsiderationsinthedevelopmentofa3dmodelrepresentativeofprimaryopenangleglaucoma AT aliciajelhaj fundamentalbiomaterialconsiderationsinthedevelopmentofa3dmodelrepresentativeofprimaryopenangleglaucoma AT lisajhill fundamentalbiomaterialconsiderationsinthedevelopmentofa3dmodelrepresentativeofprimaryopenangleglaucoma
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Fundamental Biomaterial Considerations in the Development of a 3D Model Representative of Primary Open Angle Glaucoma

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