Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells

Cancer cells can disrupt cell-to-cell junctions, thus allowing migration and metastasis. Here starting from a chemical screening, Ito et al. reconstitute a step-by-step mechanism linking microtubule depolymerization and epithelial cell junction restoration.

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Autores principales:	Shoko Ito, Satoru Okuda, Masako Abe, Mari Fujimoto, Tetsuo Onuki, Tamako Nishimura, Masatoshi Takeichi
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/554ba8c618d44f11bae72fc3ef5831e2
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spelling	oai:doaj.org-article:554ba8c618d44f11bae72fc3ef5831e22021-12-02T16:51:52ZInduced cortical tension restores functional junctions in adhesion-defective carcinoma cells10.1038/s41467-017-01945-y2041-1723https://doaj.org/article/554ba8c618d44f11bae72fc3ef5831e22017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01945-yhttps://doaj.org/toc/2041-1723Cancer cells can disrupt cell-to-cell junctions, thus allowing migration and metastasis. Here starting from a chemical screening, Ito et al. reconstitute a step-by-step mechanism linking microtubule depolymerization and epithelial cell junction restoration.Shoko ItoSatoru OkudaMasako AbeMari FujimotoTetsuo OnukiTamako NishimuraMasatoshi TakeichiNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-16 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Shoko Ito Satoru Okuda Masako Abe Mari Fujimoto Tetsuo Onuki Tamako Nishimura Masatoshi Takeichi Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
description	Cancer cells can disrupt cell-to-cell junctions, thus allowing migration and metastasis. Here starting from a chemical screening, Ito et al. reconstitute a step-by-step mechanism linking microtubule depolymerization and epithelial cell junction restoration.
format	article
author	Shoko Ito Satoru Okuda Masako Abe Mari Fujimoto Tetsuo Onuki Tamako Nishimura Masatoshi Takeichi
author_facet	Shoko Ito Satoru Okuda Masako Abe Mari Fujimoto Tetsuo Onuki Tamako Nishimura Masatoshi Takeichi
author_sort	Shoko Ito
title	Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
title_short	Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
title_full	Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
title_fullStr	Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
title_full_unstemmed	Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
title_sort	induced cortical tension restores functional junctions in adhesion-defective carcinoma cells
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/554ba8c618d44f11bae72fc3ef5831e2
work_keys_str_mv	AT shokoito inducedcorticaltensionrestoresfunctionaljunctionsinadhesiondefectivecarcinomacells AT satoruokuda inducedcorticaltensionrestoresfunctionaljunctionsinadhesiondefectivecarcinomacells AT masakoabe inducedcorticaltensionrestoresfunctionaljunctionsinadhesiondefectivecarcinomacells AT marifujimoto inducedcorticaltensionrestoresfunctionaljunctionsinadhesiondefectivecarcinomacells AT tetsuoonuki inducedcorticaltensionrestoresfunctionaljunctionsinadhesiondefectivecarcinomacells AT tamakonishimura inducedcorticaltensionrestoresfunctionaljunctionsinadhesiondefectivecarcinomacells AT masatoshitakeichi inducedcorticaltensionrestoresfunctionaljunctionsinadhesiondefectivecarcinomacells
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Induced cortical tension restores functional junctions in adhesion-defective carcinoma cells

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