Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels

Abstract Biocompatible materials that act as scaffolds for regenerative medicine are of enormous interest. Hydrogel-nanoparticle composites have great potential in this regard, however evaluations of their wound healing and safety in vivo in animal studies are scarce. Here we demonstrate that a guar...

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Autores principales:	Sakkarin Bhubhanil, Chanon Talodthaisong, Mattaka Khongkow, Katawut Namdee, Prapimpun Wongchitrat, Werayut Yingmema, James A. Hutchison, Sarawut Lapmanee, Sirinan Kulchat
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/554f67cdb39c4e48ac44aa6a688e2480
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spelling	oai:doaj.org-article:554f67cdb39c4e48ac44aa6a688e24802021-11-14T12:24:31ZEnhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels10.1038/s41598-021-01262-x2045-2322https://doaj.org/article/554f67cdb39c4e48ac44aa6a688e24802021-11-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-01262-xhttps://doaj.org/toc/2045-2322Abstract Biocompatible materials that act as scaffolds for regenerative medicine are of enormous interest. Hydrogel-nanoparticle composites have great potential in this regard, however evaluations of their wound healing and safety in vivo in animal studies are scarce. Here we demonstrate that a guar gum/curcumin-stabilized silver nanoparticle hydrogel composite is an injectable material with exceptional wound healing and antibacterial properties. We show that the curcumin-bound silver nanoparticles themselves exhibit low cytotoxicity and enhance proliferation, migration, and collagen production in in vitro studies of human dermal fibroblasts. We then show that the hydrogel-nanoparticle composite promotes wound healing in in vivo studies on rats, accelerating wound closure by > 40% and reducing bacterial counts by 60% compared to commercial antibacterial gels. Histopathology indicates that the hydrogel composite enhances transition from the inflammation to proliferation stage of healing, promoting the formation of fibroblasts and new blood vessels, while target gene expression studies confirm that the accelerated tissue remodeling occurs along the normal pathways. As such these hydrogel composites show great promise as wound dressing materials with high antibacterial capacity.Sakkarin BhubhanilChanon TalodthaisongMattaka KhongkowKatawut NamdeePrapimpun WongchitratWerayut YingmemaJames A. HutchisonSarawut LapmaneeSirinan KulchatNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-14 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Sakkarin Bhubhanil Chanon Talodthaisong Mattaka Khongkow Katawut Namdee Prapimpun Wongchitrat Werayut Yingmema James A. Hutchison Sarawut Lapmanee Sirinan Kulchat Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
description	Abstract Biocompatible materials that act as scaffolds for regenerative medicine are of enormous interest. Hydrogel-nanoparticle composites have great potential in this regard, however evaluations of their wound healing and safety in vivo in animal studies are scarce. Here we demonstrate that a guar gum/curcumin-stabilized silver nanoparticle hydrogel composite is an injectable material with exceptional wound healing and antibacterial properties. We show that the curcumin-bound silver nanoparticles themselves exhibit low cytotoxicity and enhance proliferation, migration, and collagen production in in vitro studies of human dermal fibroblasts. We then show that the hydrogel-nanoparticle composite promotes wound healing in in vivo studies on rats, accelerating wound closure by > 40% and reducing bacterial counts by 60% compared to commercial antibacterial gels. Histopathology indicates that the hydrogel composite enhances transition from the inflammation to proliferation stage of healing, promoting the formation of fibroblasts and new blood vessels, while target gene expression studies confirm that the accelerated tissue remodeling occurs along the normal pathways. As such these hydrogel composites show great promise as wound dressing materials with high antibacterial capacity.
format	article
author	Sakkarin Bhubhanil Chanon Talodthaisong Mattaka Khongkow Katawut Namdee Prapimpun Wongchitrat Werayut Yingmema James A. Hutchison Sarawut Lapmanee Sirinan Kulchat
author_facet	Sakkarin Bhubhanil Chanon Talodthaisong Mattaka Khongkow Katawut Namdee Prapimpun Wongchitrat Werayut Yingmema James A. Hutchison Sarawut Lapmanee Sirinan Kulchat
author_sort	Sakkarin Bhubhanil
title	Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
title_short	Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
title_full	Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
title_fullStr	Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
title_full_unstemmed	Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
title_sort	enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/554f67cdb39c4e48ac44aa6a688e2480
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Enhanced wound healing properties of guar gum/curcumin-stabilized silver nanoparticle hydrogels

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