MINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS)

Abstract. T cell populations, specifically, T helper (Th) cells, are among key players in the processes occurring in the body following exposure to a foreign antigen. Usage of new, highly sensitive instruments allowed of more detailed studies of their structural arrangement, as well as to detect a n...

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Autor principal:	S. V. Khaidukov
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	сytometry naїve t-cells t-helpers th9 th22 Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5550c6df742542b99cde50bd1974abe6
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spelling	oai:doaj.org-article:5550c6df742542b99cde50bd1974abe62021-11-18T08:03:43ZMINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS)1563-06252313-741X10.15789/1563-0625-2013-6-503-512https://doaj.org/article/5550c6df742542b99cde50bd1974abe62014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/670https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. T cell populations, specifically, T helper (Th) cells, are among key players in the processes occurring in the body following exposure to a foreign antigen. Usage of new, highly sensitive instruments allowed of more detailed studies of their structural arrangement, as well as to detect a number of functionally significant minor subsets. These T cell subtypes were characterized both phenotypically and functionally. Present review article concerns Th thymic naїve subsets, Th central naїve subpoppulations, Th9, Th22, and CD4+CD8+ doublepositive T cells. Their role and functional significance is discussed in various pathological conditions. At present time, there are convincing data about specific arrays of membrane molecules, transcription factors, production of specific mediators typical to either of these subsets. Application of these markers in laboratory studies, will certainly improve diagnostic quality when evaluating functional alterations of immune system and adequacy of prescribed immunotherapy.S. V. KhaidukovSPb RAACIarticleсytometrynaїve t-cellst-helpersth9th22Immunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 15, Iss 6, Pp 503-512 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	сytometry naїve t-cells t-helpers th9 th22 Immunologic diseases. Allergy RC581-607
spellingShingle	сytometry naїve t-cells t-helpers th9 th22 Immunologic diseases. Allergy RC581-607 S. V. Khaidukov MINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS)
description	Abstract. T cell populations, specifically, T helper (Th) cells, are among key players in the processes occurring in the body following exposure to a foreign antigen. Usage of new, highly sensitive instruments allowed of more detailed studies of their structural arrangement, as well as to detect a number of functionally significant minor subsets. These T cell subtypes were characterized both phenotypically and functionally. Present review article concerns Th thymic naїve subsets, Th central naїve subpoppulations, Th9, Th22, and CD4+CD8+ doublepositive T cells. Their role and functional significance is discussed in various pathological conditions. At present time, there are convincing data about specific arrays of membrane molecules, transcription factors, production of specific mediators typical to either of these subsets. Application of these markers in laboratory studies, will certainly improve diagnostic quality when evaluating functional alterations of immune system and adequacy of prescribed immunotherapy.
format	article
author	S. V. Khaidukov
author_facet	S. V. Khaidukov
author_sort	S. V. Khaidukov
title	MINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS)
title_short	MINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS)
title_full	MINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS)
title_fullStr	MINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS)
title_full_unstemmed	MINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS)
title_sort	minor subsets of t-helper cells (th thymic naive, th central naive, th9, th22 and cd4+cd8+ double positive t-cells)
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/5550c6df742542b99cde50bd1974abe6
work_keys_str_mv	AT svkhaidukov minorsubsetsofthelpercellsththymicnaivethcentralnaiveth9th22andcd4cd8doublepositivetcells
_version_	1718422416848322560

MINOR SUBSETS OF T-HELPER CELLS (Th THYMIC NAIVE, Th CENTRAL NAIVE, Th9, Th22 AND CD4+CD8+ DOUBLE POSITIVE T-CELLS)

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