The clinical and pathological characteristics and survival of patients with advanced ovarian cancer

Introduction: Ovarian cancer has the highest mortality rate of all gynaecologic malignancies. The aim of this study was the evaluation of the clinical pathological characteristics and survival analysis of primarily operated patients with advanced stages of malignant epithelial ovarian tumour. Method...

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Autores principales:	Popović Miroslav, Milić-Radić Tanja, Cerić-Banićević Arnela
Formato:	article
Lenguaje:	EN SR
Publicado:	Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine 2021
Materias:	ovarian cancer radical surgery survival rate clinical features pathological features Medicine R
Acceso en línea:	https://doaj.org/article/5551f696c58a4f69850768113ef803d0
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spelling	oai:doaj.org-article:5551f696c58a4f69850768113ef803d02021-12-05T21:31:53ZThe clinical and pathological characteristics and survival of patients with advanced ovarian cancer2490-33292303-795410.5937/scriptamed52-33897https://doaj.org/article/5551f696c58a4f69850768113ef803d02021-01-01T00:00:00Zhttps://scindeks-clanci.ceon.rs/data/pdf/2490-3329/2021/2490-33292103205P.pdfhttps://doaj.org/toc/2490-3329https://doaj.org/toc/2303-7954Introduction: Ovarian cancer has the highest mortality rate of all gynaecologic malignancies. The aim of this study was the evaluation of the clinical pathological characteristics and survival analysis of primarily operated patients with advanced stages of malignant epithelial ovarian tumour. Methods: The research was conducted as a cohort study with 59 patients with FIGO stage III and IV, which were primarily operated between 1 January 2008 and 31 December 2010 (three years). Age, comorbidities, BMI, presence of ascites, the level of the marker CA-125, histopathology and FIGO stage were analysed. The survival rate was estimated at the level of 1, 3 and 5 years. Results: The median age was 53 years (range 29-86). The most common histopathological type was serous (66.1 %) and the most common FIGO stage was 3a (49.2 %). Optimal cytoreduction was performed in 35.5 % of patients, 84.7 % of patients survived for one year, 44.1 % three years and 37.3 % for five years. The median survival was 26.25 months (range 0-91). Chi-square test showed significant difference between the number of months of survival and: the value of CA125 (t = 2.004, p = 0.050), cytoreduction (p < 0.001) and FIGO stage (p < 0.01). Conclusion: According to the results of this study, optimal cytoreduction and FIGO stage significantly influence survival (p < 0.001). Optimal cytoreduction (< 2 cm of residual disease) had the highest prognostic value for survival. A total five-year survival in this study was 37.3 %.Popović MiroslavMilić-Radić TanjaCerić-Banićević ArnelaMedical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicinearticleovarian cancerradical surgerysurvival rateclinical featurespathological featuresMedicineRENSRScripta Medica, Vol 52, Iss 3, Pp 205-210 (2021)
institution	DOAJ
collection	DOAJ
language	EN SR
topic	ovarian cancer radical surgery survival rate clinical features pathological features Medicine R
spellingShingle	ovarian cancer radical surgery survival rate clinical features pathological features Medicine R Popović Miroslav Milić-Radić Tanja Cerić-Banićević Arnela The clinical and pathological characteristics and survival of patients with advanced ovarian cancer
description	Introduction: Ovarian cancer has the highest mortality rate of all gynaecologic malignancies. The aim of this study was the evaluation of the clinical pathological characteristics and survival analysis of primarily operated patients with advanced stages of malignant epithelial ovarian tumour. Methods: The research was conducted as a cohort study with 59 patients with FIGO stage III and IV, which were primarily operated between 1 January 2008 and 31 December 2010 (three years). Age, comorbidities, BMI, presence of ascites, the level of the marker CA-125, histopathology and FIGO stage were analysed. The survival rate was estimated at the level of 1, 3 and 5 years. Results: The median age was 53 years (range 29-86). The most common histopathological type was serous (66.1 %) and the most common FIGO stage was 3a (49.2 %). Optimal cytoreduction was performed in 35.5 % of patients, 84.7 % of patients survived for one year, 44.1 % three years and 37.3 % for five years. The median survival was 26.25 months (range 0-91). Chi-square test showed significant difference between the number of months of survival and: the value of CA125 (t = 2.004, p = 0.050), cytoreduction (p < 0.001) and FIGO stage (p < 0.01). Conclusion: According to the results of this study, optimal cytoreduction and FIGO stage significantly influence survival (p < 0.001). Optimal cytoreduction (< 2 cm of residual disease) had the highest prognostic value for survival. A total five-year survival in this study was 37.3 %.
format	article
author	Popović Miroslav Milić-Radić Tanja Cerić-Banićević Arnela
author_facet	Popović Miroslav Milić-Radić Tanja Cerić-Banićević Arnela
author_sort	Popović Miroslav
title	The clinical and pathological characteristics and survival of patients with advanced ovarian cancer
title_short	The clinical and pathological characteristics and survival of patients with advanced ovarian cancer
title_full	The clinical and pathological characteristics and survival of patients with advanced ovarian cancer
title_fullStr	The clinical and pathological characteristics and survival of patients with advanced ovarian cancer
title_full_unstemmed	The clinical and pathological characteristics and survival of patients with advanced ovarian cancer
title_sort	clinical and pathological characteristics and survival of patients with advanced ovarian cancer
publisher	Medical Society of the Republic of Srpska, Banja Luka, University of Banja Luka. Faculty of Medicine
publishDate	2021
url	https://doaj.org/article/5551f696c58a4f69850768113ef803d0
work_keys_str_mv	AT popovicmiroslav theclinicalandpathologicalcharacteristicsandsurvivalofpatientswithadvancedovariancancer AT milicradictanja theclinicalandpathologicalcharacteristicsandsurvivalofpatientswithadvancedovariancancer AT cericbanicevicarnela theclinicalandpathologicalcharacteristicsandsurvivalofpatientswithadvancedovariancancer AT popovicmiroslav clinicalandpathologicalcharacteristicsandsurvivalofpatientswithadvancedovariancancer AT milicradictanja clinicalandpathologicalcharacteristicsandsurvivalofpatientswithadvancedovariancancer AT cericbanicevicarnela clinicalandpathologicalcharacteristicsandsurvivalofpatientswithadvancedovariancancer
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The clinical and pathological characteristics and survival of patients with advanced ovarian cancer

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