Metabolic flexibility during sleep

Abstract Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the...

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Autores principales:	Simeng Zhang, Yoshiaki Tanaka, Asuka Ishihara, Akiko Uchizawa, Insung Park, Kaito Iwayama, Hitomi Ogata, Katsuhiko Yajima, Naomi Omi, Makoto Satoh, Masashi Yanagisawa, Hiroyuki Sagayama, Kumpei Tokuyama
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/555456dd18f44553b8daa3a00c51eff0
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spelling	oai:doaj.org-article:555456dd18f44553b8daa3a00c51eff02021-12-02T17:19:17ZMetabolic flexibility during sleep10.1038/s41598-021-97301-82045-2322https://doaj.org/article/555456dd18f44553b8daa3a00c51eff02021-09-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-97301-8https://doaj.org/toc/2045-2322Abstract Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.Simeng ZhangYoshiaki TanakaAsuka IshiharaAkiko UchizawaInsung ParkKaito IwayamaHitomi OgataKatsuhiko YajimaNaomi OmiMakoto SatohMasashi YanagisawaHiroyuki SagayamaKumpei TokuyamaNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-13 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Simeng Zhang Yoshiaki Tanaka Asuka Ishihara Akiko Uchizawa Insung Park Kaito Iwayama Hitomi Ogata Katsuhiko Yajima Naomi Omi Makoto Satoh Masashi Yanagisawa Hiroyuki Sagayama Kumpei Tokuyama Metabolic flexibility during sleep
description	Abstract Known as metabolic flexibility, oxidized substrate is selected in response to changes in the nutritional state. Sleep imposes an extended duration of fasting, and oxidized substrates during sleep were assumed to progressively shift from carbohydrate to fat, thereby gradually decreasing the respiratory quotient (RQ). Contrary to this assumption, whole-room indirect calorimetry with improved time resolution revealed that RQ re-ascended prior to awakening, and nadir of RQ in non-obese young adults occurred earlier in women than men after bedtime. The transient decrease in RQ during sleep was blunted in metabolically inflexible men with smaller amplitude of diurnal rhythm in RQ. Similarly, the effect of 10 years difference in age on RQ became significant during sleep; the decrease in RQ during sleep was blunted in older subjects. Inter-individual difference in RQ become apparent during sleep, and it might serve as a window to gain insight into the early-stage pathogenesis of metabolic inflexibility.
format	article
author	Simeng Zhang Yoshiaki Tanaka Asuka Ishihara Akiko Uchizawa Insung Park Kaito Iwayama Hitomi Ogata Katsuhiko Yajima Naomi Omi Makoto Satoh Masashi Yanagisawa Hiroyuki Sagayama Kumpei Tokuyama
author_facet	Simeng Zhang Yoshiaki Tanaka Asuka Ishihara Akiko Uchizawa Insung Park Kaito Iwayama Hitomi Ogata Katsuhiko Yajima Naomi Omi Makoto Satoh Masashi Yanagisawa Hiroyuki Sagayama Kumpei Tokuyama
author_sort	Simeng Zhang
title	Metabolic flexibility during sleep
title_short	Metabolic flexibility during sleep
title_full	Metabolic flexibility during sleep
title_fullStr	Metabolic flexibility during sleep
title_full_unstemmed	Metabolic flexibility during sleep
title_sort	metabolic flexibility during sleep
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/555456dd18f44553b8daa3a00c51eff0
work_keys_str_mv	AT simengzhang metabolicflexibilityduringsleep AT yoshiakitanaka metabolicflexibilityduringsleep AT asukaishihara metabolicflexibilityduringsleep AT akikouchizawa metabolicflexibilityduringsleep AT insungpark metabolicflexibilityduringsleep AT kaitoiwayama metabolicflexibilityduringsleep AT hitomiogata metabolicflexibilityduringsleep AT katsuhikoyajima metabolicflexibilityduringsleep AT naomiomi metabolicflexibilityduringsleep AT makotosatoh metabolicflexibilityduringsleep AT masashiyanagisawa metabolicflexibilityduringsleep AT hiroyukisagayama metabolicflexibilityduringsleep AT kumpeitokuyama metabolicflexibilityduringsleep
_version_	1718381026002075648

Metabolic flexibility during sleep

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