INCREASED SPONTANEOUS APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH PARKINSON’S DISEASE

Abstract. Progressive loss of dopaminergic neurons from substantia nigra is the major pathomorphologicasign in Parkinson’s disease (PD). Neuronal death is suggested to occur by programmed cell death (apoptosis) in PD patients, thus being involved into the mechanisms of neurodegeneration. Indirect si...

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Autores principales:	S. N. Pchelina, T. S. Usenko, N. A. Bogankova, A. F. Yakimovskii, A. K. Emelyanov, T. V. Vavilova, A. L. Shvartsman
Formato:	article
Lenguaje:	RU
Publicado:	SPb RAACI 2014
Materias:	parkinson’s disease apoptosis lymphocytes Immunologic diseases. Allergy RC581-607
Acceso en línea:	https://doaj.org/article/5554853da64c40bbacf5a76c91bd7f11
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spelling	oai:doaj.org-article:5554853da64c40bbacf5a76c91bd7f112021-11-18T08:03:40ZINCREASED SPONTANEOUS APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH PARKINSON’S DISEASE1563-06252313-741X10.15789/1563-0625-2012-1-2-149-152https://doaj.org/article/5554853da64c40bbacf5a76c91bd7f112014-07-01T00:00:00Zhttps://www.mimmun.ru/mimmun/article/view/318https://doaj.org/toc/1563-0625https://doaj.org/toc/2313-741XAbstract. Progressive loss of dopaminergic neurons from substantia nigra is the major pathomorphologicasign in Parkinson’s disease (PD). Neuronal death is suggested to occur by programmed cell death (apoptosis) in PD patients, thus being involved into the mechanisms of neurodegeneration. Indirect signs of apoptosis may be revealed in peripheral blood lymphocytes (PBL) from PD patients. Using flow cytometry and annexin V-binding kit (PI + Annexin V FITC), we estimated PBL apoptosis in nine patients with PD (four untreated cases and five persons treated with L-DOPA), as compared with nine control persons. Spontaneous apoptosis at 24 h was higher in PD patients, as compared with controls (p < 0.01). Apoptosis rate was lower in patients receiving therapy with L-DOPA, than in untreated patients (p < 0.01). Our results support a possible role of apoptosis in PD pathogenesis, and suggest some effects of L-DOPA treatment upon apoptotic rates of peripheral blood lymphocytes.S. N. PchelinaT. S. UsenkoN. A. BogankovaA. F. YakimovskiiA. K. EmelyanovT. V. VavilovaA. L. ShvartsmanSPb RAACIarticleparkinson’s diseaseapoptosislymphocytesImmunologic diseases. AllergyRC581-607RUMedicinskaâ Immunologiâ, Vol 14, Iss 1-2, Pp 149-152 (2014)
institution	DOAJ
collection	DOAJ
language	RU
topic	parkinson’s disease apoptosis lymphocytes Immunologic diseases. Allergy RC581-607
spellingShingle	parkinson’s disease apoptosis lymphocytes Immunologic diseases. Allergy RC581-607 S. N. Pchelina T. S. Usenko N. A. Bogankova A. F. Yakimovskii A. K. Emelyanov T. V. Vavilova A. L. Shvartsman INCREASED SPONTANEOUS APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH PARKINSON’S DISEASE
description	Abstract. Progressive loss of dopaminergic neurons from substantia nigra is the major pathomorphologicasign in Parkinson’s disease (PD). Neuronal death is suggested to occur by programmed cell death (apoptosis) in PD patients, thus being involved into the mechanisms of neurodegeneration. Indirect signs of apoptosis may be revealed in peripheral blood lymphocytes (PBL) from PD patients. Using flow cytometry and annexin V-binding kit (PI + Annexin V FITC), we estimated PBL apoptosis in nine patients with PD (four untreated cases and five persons treated with L-DOPA), as compared with nine control persons. Spontaneous apoptosis at 24 h was higher in PD patients, as compared with controls (p < 0.01). Apoptosis rate was lower in patients receiving therapy with L-DOPA, than in untreated patients (p < 0.01). Our results support a possible role of apoptosis in PD pathogenesis, and suggest some effects of L-DOPA treatment upon apoptotic rates of peripheral blood lymphocytes.
format	article
author	S. N. Pchelina T. S. Usenko N. A. Bogankova A. F. Yakimovskii A. K. Emelyanov T. V. Vavilova A. L. Shvartsman
author_facet	S. N. Pchelina T. S. Usenko N. A. Bogankova A. F. Yakimovskii A. K. Emelyanov T. V. Vavilova A. L. Shvartsman
author_sort	S. N. Pchelina
title	INCREASED SPONTANEOUS APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH PARKINSON’S DISEASE
title_short	INCREASED SPONTANEOUS APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH PARKINSON’S DISEASE
title_full	INCREASED SPONTANEOUS APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH PARKINSON’S DISEASE
title_fullStr	INCREASED SPONTANEOUS APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH PARKINSON’S DISEASE
title_full_unstemmed	INCREASED SPONTANEOUS APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH PARKINSON’S DISEASE
title_sort	increased spontaneous apoptosis of peripheral blood lymphocytes from patients with parkinson’s disease
publisher	SPb RAACI
publishDate	2014
url	https://doaj.org/article/5554853da64c40bbacf5a76c91bd7f11
work_keys_str_mv	AT snpchelina increasedspontaneousapoptosisofperipheralbloodlymphocytesfrompatientswithparkinsonsdisease AT tsusenko increasedspontaneousapoptosisofperipheralbloodlymphocytesfrompatientswithparkinsonsdisease AT nabogankova increasedspontaneousapoptosisofperipheralbloodlymphocytesfrompatientswithparkinsonsdisease AT afyakimovskii increasedspontaneousapoptosisofperipheralbloodlymphocytesfrompatientswithparkinsonsdisease AT akemelyanov increasedspontaneousapoptosisofperipheralbloodlymphocytesfrompatientswithparkinsonsdisease AT tvvavilova increasedspontaneousapoptosisofperipheralbloodlymphocytesfrompatientswithparkinsonsdisease AT alshvartsman increasedspontaneousapoptosisofperipheralbloodlymphocytesfrompatientswithparkinsonsdisease
_version_	1718422477690896384

INCREASED SPONTANEOUS APOPTOSIS OF PERIPHERAL BLOOD LYMPHOCYTES FROM PATIENTS WITH PARKINSON’S DISEASE

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