Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy

Altered lipid metabolism has been associated with tumour malignancy, but underlying mechanisms are not clear. Here the authors show that proto-oncogene Src interacts and phosphorylates metabolic enzyme phosphatidic acid phosphatase LPIN1 (lipin-1) to promote growth and metastasis in breast cancer.

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Autores principales:	Lintao Song, Zhihua Liu, Hui-Hui Hu, Ying Yang, Terytty Yang Li, Zhi-Zhong Lin, Jing Ye, Jianing Chen, Xi Huang, Dong-Tai Liu, Jing Zhou, Yiran Shi, Hao Zhao, Changchuan Xie, Lanfen Chen, Erwei Song, Shu-Yong Lin, Sheng-Cai Lin
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55567eb2dbc94cf98986aa9649f0ce7a
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spelling	oai:doaj.org-article:55567eb2dbc94cf98986aa9649f0ce7a2021-12-02T15:37:07ZProto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy10.1038/s41467-020-19694-w2041-1723https://doaj.org/article/55567eb2dbc94cf98986aa9649f0ce7a2020-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-19694-whttps://doaj.org/toc/2041-1723Altered lipid metabolism has been associated with tumour malignancy, but underlying mechanisms are not clear. Here the authors show that proto-oncogene Src interacts and phosphorylates metabolic enzyme phosphatidic acid phosphatase LPIN1 (lipin-1) to promote growth and metastasis in breast cancer.Lintao SongZhihua LiuHui-Hui HuYing YangTerytty Yang LiZhi-Zhong LinJing YeJianing ChenXi HuangDong-Tai LiuJing ZhouYiran ShiHao ZhaoChangchuan XieLanfen ChenErwei SongShu-Yong LinSheng-Cai LinNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Lintao Song Zhihua Liu Hui-Hui Hu Ying Yang Terytty Yang Li Zhi-Zhong Lin Jing Ye Jianing Chen Xi Huang Dong-Tai Liu Jing Zhou Yiran Shi Hao Zhao Changchuan Xie Lanfen Chen Erwei Song Shu-Yong Lin Sheng-Cai Lin Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
description	Altered lipid metabolism has been associated with tumour malignancy, but underlying mechanisms are not clear. Here the authors show that proto-oncogene Src interacts and phosphorylates metabolic enzyme phosphatidic acid phosphatase LPIN1 (lipin-1) to promote growth and metastasis in breast cancer.
format	article
author	Lintao Song Zhihua Liu Hui-Hui Hu Ying Yang Terytty Yang Li Zhi-Zhong Lin Jing Ye Jianing Chen Xi Huang Dong-Tai Liu Jing Zhou Yiran Shi Hao Zhao Changchuan Xie Lanfen Chen Erwei Song Shu-Yong Lin Sheng-Cai Lin
author_facet	Lintao Song Zhihua Liu Hui-Hui Hu Ying Yang Terytty Yang Li Zhi-Zhong Lin Jing Ye Jianing Chen Xi Huang Dong-Tai Liu Jing Zhou Yiran Shi Hao Zhao Changchuan Xie Lanfen Chen Erwei Song Shu-Yong Lin Sheng-Cai Lin
author_sort	Lintao Song
title	Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
title_short	Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
title_full	Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
title_fullStr	Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
title_full_unstemmed	Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy
title_sort	proto-oncogene src links lipogenesis via lipin-1 to breast cancer malignancy
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/55567eb2dbc94cf98986aa9649f0ce7a
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Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy

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