Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy

Proto-oncogene Src links lipogenesis via lipin-1 to breast cancer malignancy

Altered lipid metabolism has been associated with tumour malignancy, but underlying mechanisms are not clear. Here the authors show that proto-oncogene Src interacts and phosphorylates metabolic enzyme phosphatidic acid phosphatase LPIN1 (lipin-1) to promote growth and metastasis in breast cancer.

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Detalles Bibliográficos
Autores principales: Lintao Song, Zhihua Liu, Hui-Hui Hu, Ying Yang, Terytty Yang Li, Zhi-Zhong Lin, Jing Ye, Jianing Chen, Xi Huang, Dong-Tai Liu, Jing Zhou, Yiran Shi, Hao Zhao, Changchuan Xie, Lanfen Chen, Erwei Song, Shu-Yong Lin, Sheng-Cai Lin
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2020
Materias:
Science
Q
Acceso en línea:https://doaj.org/article/55567eb2dbc94cf98986aa9649f0ce7a
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