Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy

Ziziphi Spinosae Semen (ZSS) is a common natural medicine used to treat insomnia, and to show clearly its method of action, we managed and did an in-depth discussion. Network pharmacology research is very suitable for the analysis of multiple components, multiple targets, and multiple pathways of Tr...

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Autores principales: Gong Feipeng, Xie Luxin, Chen Beili, Yang Songhong, Wu Wenting, Li Junmao, Gong Qianfeng, Zhong Lingyun, Wu Jianxiong
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Publicado: Hindawi Limited 2021
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Acceso en línea:https://doaj.org/article/55575a0d92f4482dbf06016818dbb098
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spelling oai:doaj.org-article:55575a0d92f4482dbf06016818dbb0982021-11-08T02:36:59ZExploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy1741-428810.1155/2021/9888607https://doaj.org/article/55575a0d92f4482dbf06016818dbb0982021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/9888607https://doaj.org/toc/1741-4288Ziziphi Spinosae Semen (ZSS) is a common natural medicine used to treat insomnia, and to show clearly its method of action, we managed and did an in-depth discussion. Network pharmacology research is very suitable for the analysis of multiple components, multiple targets, and multiple pathways of Traditional Chinese Medicine (TCM). According to the relevant theory, we first carefully collected and screened the active ingredients in ZSS and received 11 active ingredients that may work. The targets going along with these active components were also strongly related to insomnia targets, 108 common genes were identified, and drug-compound-gene symbol-disease visualization network and protein-protein interaction network were constructed. Forty-eight core genes were identified by PPI analysis and subjected to GO functional analysis with KEGG pathway analysis. The results of GO analysis pointed that there were 998 gene ontology items for the treatment of insomnia, including terms of 892 biological processes, 47 cellular components, and 59 molecular functions. It mainly shows the coupling effect and transport mode of some proteins in the biological pathways of ZSS in the treatment of insomnia and explains the mechanism of action through the connection between the target and the cell biomembrane. KEGG enrichment analyzed 19 signaling pathways, which were collectively classified into seven categories. We have identified the potential pathways of ZSS against insomnia and obtained the regulatory relationship between core genes and pathways and know that the same target can be regulated by multiple components at the same time. The results of molecular docking also prove this conclusion. We sought to provide a new analytical approach to explore TCM treatments for diseases using network pharmacology analysis tools.Gong FeipengXie LuxinChen BeiliYang SonghongWu WentingLi JunmaoGong QianfengZhong LingyunWu JianxiongHindawi LimitedarticleOther systems of medicineRZ201-999ENEvidence-Based Complementary and Alternative Medicine, Vol 2021 (2021)
institution DOAJ
collection DOAJ
language EN
topic Other systems of medicine
RZ201-999
spellingShingle Other systems of medicine
RZ201-999
Gong Feipeng
Xie Luxin
Chen Beili
Yang Songhong
Wu Wenting
Li Junmao
Gong Qianfeng
Zhong Lingyun
Wu Jianxiong
Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy
description Ziziphi Spinosae Semen (ZSS) is a common natural medicine used to treat insomnia, and to show clearly its method of action, we managed and did an in-depth discussion. Network pharmacology research is very suitable for the analysis of multiple components, multiple targets, and multiple pathways of Traditional Chinese Medicine (TCM). According to the relevant theory, we first carefully collected and screened the active ingredients in ZSS and received 11 active ingredients that may work. The targets going along with these active components were also strongly related to insomnia targets, 108 common genes were identified, and drug-compound-gene symbol-disease visualization network and protein-protein interaction network were constructed. Forty-eight core genes were identified by PPI analysis and subjected to GO functional analysis with KEGG pathway analysis. The results of GO analysis pointed that there were 998 gene ontology items for the treatment of insomnia, including terms of 892 biological processes, 47 cellular components, and 59 molecular functions. It mainly shows the coupling effect and transport mode of some proteins in the biological pathways of ZSS in the treatment of insomnia and explains the mechanism of action through the connection between the target and the cell biomembrane. KEGG enrichment analyzed 19 signaling pathways, which were collectively classified into seven categories. We have identified the potential pathways of ZSS against insomnia and obtained the regulatory relationship between core genes and pathways and know that the same target can be regulated by multiple components at the same time. The results of molecular docking also prove this conclusion. We sought to provide a new analytical approach to explore TCM treatments for diseases using network pharmacology analysis tools.
format article
author Gong Feipeng
Xie Luxin
Chen Beili
Yang Songhong
Wu Wenting
Li Junmao
Gong Qianfeng
Zhong Lingyun
Wu Jianxiong
author_facet Gong Feipeng
Xie Luxin
Chen Beili
Yang Songhong
Wu Wenting
Li Junmao
Gong Qianfeng
Zhong Lingyun
Wu Jianxiong
author_sort Gong Feipeng
title Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy
title_short Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy
title_full Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy
title_fullStr Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy
title_full_unstemmed Exploration of Ziziphi Spinosae Semen in Treating Insomnia Based on Network Pharmacology Strategy
title_sort exploration of ziziphi spinosae semen in treating insomnia based on network pharmacology strategy
publisher Hindawi Limited
publishDate 2021
url https://doaj.org/article/55575a0d92f4482dbf06016818dbb098
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