Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.

<h4>Background</h4>Epstein Barr virus-associated lymphoproliferative disease is an increasing complication in patients with immunosuppressive conditions. Although the current therapies for this disorder are effective, they are also associated with significant toxicity. In an attempt to i...

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Autores principales:	J Luis Espinoza, Akiyoshi Takami, Ly Quoc Trung, Shunichi Kato, Shinji Nakao
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2012
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5558fa7bf19344a3b84e51a3f79eb6b2
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spelling	oai:doaj.org-article:5558fa7bf19344a3b84e51a3f79eb6b22021-11-18T08:05:45ZResveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.1932-620310.1371/journal.pone.0051306https://doaj.org/article/5558fa7bf19344a3b84e51a3f79eb6b22012-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/23251493/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Epstein Barr virus-associated lymphoproliferative disease is an increasing complication in patients with immunosuppressive conditions. Although the current therapies for this disorder are effective, they are also associated with significant toxicity. In an attempt to identify newer therapeutic agents, this study investigated the effects of Resveratrol, a naturally occurring polyphenolic compound, on the EBV transformation of human B cells.<h4>Methodology/principal findings</h4>This study demonstrates that resveratrol prevents EBV transformation in human B cells. These effects are mediated by specific cytotoxic activities of resveratrol against EBV-infected B cells that are associated with the downregulation of the anti-apoptotic proteins Mcl-1 and survivin. This occurs as a consequence of the inhibition of EBV-induced NFκB and STAT-3 signaling pathways and a resveratrol-induced decrease in the expression of the oncogenic viral product LMP1 in EBV-infected B cells. In addition, resveratrol decreased the expression of miR-155 and miR-34a in EBV-infected B cells, blocked the expression of the anti-apoptotic viral gene BHRF1, and thus interrupted events that are critical for EBV transformation and the survival of EBV-transformed cells.<h4>Conclusions/significance</h4>These results suggest that resveratrol may therefore be a potentially effective therapeutic alternative for preventing EBV-associated lymphoproliferative diseases in immune compromised patients.J Luis EspinozaAkiyoshi TakamiLy Quoc TrungShunichi KatoShinji NakaoPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 7, Iss 12, p e51306 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q J Luis Espinoza Akiyoshi Takami Ly Quoc Trung Shunichi Kato Shinji Nakao Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.
description	<h4>Background</h4>Epstein Barr virus-associated lymphoproliferative disease is an increasing complication in patients with immunosuppressive conditions. Although the current therapies for this disorder are effective, they are also associated with significant toxicity. In an attempt to identify newer therapeutic agents, this study investigated the effects of Resveratrol, a naturally occurring polyphenolic compound, on the EBV transformation of human B cells.<h4>Methodology/principal findings</h4>This study demonstrates that resveratrol prevents EBV transformation in human B cells. These effects are mediated by specific cytotoxic activities of resveratrol against EBV-infected B cells that are associated with the downregulation of the anti-apoptotic proteins Mcl-1 and survivin. This occurs as a consequence of the inhibition of EBV-induced NFκB and STAT-3 signaling pathways and a resveratrol-induced decrease in the expression of the oncogenic viral product LMP1 in EBV-infected B cells. In addition, resveratrol decreased the expression of miR-155 and miR-34a in EBV-infected B cells, blocked the expression of the anti-apoptotic viral gene BHRF1, and thus interrupted events that are critical for EBV transformation and the survival of EBV-transformed cells.<h4>Conclusions/significance</h4>These results suggest that resveratrol may therefore be a potentially effective therapeutic alternative for preventing EBV-associated lymphoproliferative diseases in immune compromised patients.
format	article
author	J Luis Espinoza Akiyoshi Takami Ly Quoc Trung Shunichi Kato Shinji Nakao
author_facet	J Luis Espinoza Akiyoshi Takami Ly Quoc Trung Shunichi Kato Shinji Nakao
author_sort	J Luis Espinoza
title	Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.
title_short	Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.
title_full	Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.
title_fullStr	Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.
title_full_unstemmed	Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.
title_sort	resveratrol prevents ebv transformation and inhibits the outgrowth of ebv-immortalized human b cells.
publisher	Public Library of Science (PLoS)
publishDate	2012
url	https://doaj.org/article/5558fa7bf19344a3b84e51a3f79eb6b2
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Resveratrol prevents EBV transformation and inhibits the outgrowth of EBV-immortalized human B cells.

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