IMPROVE observational program: safety and effectiveness of biphasic insulin aspart 30 in routine clinical practice. Overview of starting characteristics of the Russian patient cohort

AIM: To analyse starting characteristics of the Russian patient cohort included in the IMPROVE observational program with reference to its demographiccomposition and clinical features of the disease in patients allocated to different groups depending on previous treatment, reason for prescribing DiA...

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Autores principales:	Marina Vladimirovna Shestakova, Akill Ballan
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2009
Materias:	type 2 diabetes mellitus improve observational study insulin therapy diasp 30 (novomix 30) Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/5559038c5c01444990377c7ad5906eb9
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spelling	oai:doaj.org-article:5559038c5c01444990377c7ad5906eb92021-11-14T09:00:14ZIMPROVE observational program: safety and effectiveness of biphasic insulin aspart 30 in routine clinical practice. Overview of starting characteristics of the Russian patient cohort2072-03512072-037810.14341/2072-0351-5713https://doaj.org/article/5559038c5c01444990377c7ad5906eb92009-12-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5713https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378AIM: To analyse starting characteristics of the Russian patient cohort included in the IMPROVE observational program with reference to its demographiccomposition and clinical features of the disease in patients allocated to different groups depending on previous treatment, reason for prescribing DiAsp 30 (NovoMix 30) therapy, and its initial dosage regime. METHODS: The analysis covered the cohort of Russian patients included in the IMPROVE global program, an open non-randomizedobservational multicentre study of safety and effectiveness of insulin DiAsp for patients with DM2 during 26 weeks of routine clinical practice. In thepreceding period, the patients (n=4869) received either oral hypoglycemic agents (OHAs) (n=2430) or insulin +/- OHAs (n=2343); the controlgroup was comprised of 95 patients given no previous antidiabetic treatment. RESULTS: Most patients had inadequate glycemic control prior to DiAsp therapy with the mean HbA1c level of 9,2%. Those given no previous antidiabetictreatment showed the highest HbA1c level (9,9%) and higher frequency of microvascular vs macrovascular complications (91 and 51% respectively).Patients that used the largest amount of antidiabetic agents developed the highest number of complications; this situation reflects therelationship between poor glycemic control and the risk of complications. CONCLUSIONS: The Russian patient cohort is one of the three largest ones in the IMPROVE? global program. They reside in different geographic regions,have different history of antidiabetic treatment and far-from-normal HbA1c levels as a result of altogether poor glycemic control in Russian patientswith DM2. The cohort at large exhibits a suboptimal HbA1c level even though the majority of the patient have an access to antidiabetic therapy. Mostphysicians participating in the study refer to improved glycemic control in their DM2 patients (lowered HbA1c, fasting and postprandial glucose levels)as the main reason for the initiation of therapy with DiAsp 30 (NovoMix 30).Marina Vladimirovna ShestakovaAkill BallanEndocrinology Research Centrearticletype 2 diabetes mellitusimprove observational studyinsulin therapydiasp 30 (novomix 30)Nutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 12, Iss 4, Pp 93-97 (2009)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	type 2 diabetes mellitus improve observational study insulin therapy diasp 30 (novomix 30) Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	type 2 diabetes mellitus improve observational study insulin therapy diasp 30 (novomix 30) Nutritional diseases. Deficiency diseases RC620-627 Marina Vladimirovna Shestakova Akill Ballan IMPROVE observational program: safety and effectiveness of biphasic insulin aspart 30 in routine clinical practice. Overview of starting characteristics of the Russian patient cohort
description	AIM: To analyse starting characteristics of the Russian patient cohort included in the IMPROVE observational program with reference to its demographiccomposition and clinical features of the disease in patients allocated to different groups depending on previous treatment, reason for prescribing DiAsp 30 (NovoMix 30) therapy, and its initial dosage regime. METHODS: The analysis covered the cohort of Russian patients included in the IMPROVE global program, an open non-randomizedobservational multicentre study of safety and effectiveness of insulin DiAsp for patients with DM2 during 26 weeks of routine clinical practice. In thepreceding period, the patients (n=4869) received either oral hypoglycemic agents (OHAs) (n=2430) or insulin +/- OHAs (n=2343); the controlgroup was comprised of 95 patients given no previous antidiabetic treatment. RESULTS: Most patients had inadequate glycemic control prior to DiAsp therapy with the mean HbA1c level of 9,2%. Those given no previous antidiabetictreatment showed the highest HbA1c level (9,9%) and higher frequency of microvascular vs macrovascular complications (91 and 51% respectively).Patients that used the largest amount of antidiabetic agents developed the highest number of complications; this situation reflects therelationship between poor glycemic control and the risk of complications. CONCLUSIONS: The Russian patient cohort is one of the three largest ones in the IMPROVE? global program. They reside in different geographic regions,have different history of antidiabetic treatment and far-from-normal HbA1c levels as a result of altogether poor glycemic control in Russian patientswith DM2. The cohort at large exhibits a suboptimal HbA1c level even though the majority of the patient have an access to antidiabetic therapy. Mostphysicians participating in the study refer to improved glycemic control in their DM2 patients (lowered HbA1c, fasting and postprandial glucose levels)as the main reason for the initiation of therapy with DiAsp 30 (NovoMix 30).
format	article
author	Marina Vladimirovna Shestakova Akill Ballan
author_facet	Marina Vladimirovna Shestakova Akill Ballan
author_sort	Marina Vladimirovna Shestakova
title	IMPROVE observational program: safety and effectiveness of biphasic insulin aspart 30 in routine clinical practice. Overview of starting characteristics of the Russian patient cohort
title_short	IMPROVE observational program: safety and effectiveness of biphasic insulin aspart 30 in routine clinical practice. Overview of starting characteristics of the Russian patient cohort
title_full	IMPROVE observational program: safety and effectiveness of biphasic insulin aspart 30 in routine clinical practice. Overview of starting characteristics of the Russian patient cohort
title_fullStr	IMPROVE observational program: safety and effectiveness of biphasic insulin aspart 30 in routine clinical practice. Overview of starting characteristics of the Russian patient cohort
title_full_unstemmed	IMPROVE observational program: safety and effectiveness of biphasic insulin aspart 30 in routine clinical practice. Overview of starting characteristics of the Russian patient cohort
title_sort	improve observational program: safety and effectiveness of biphasic insulin aspart 30 in routine clinical practice. overview of starting characteristics of the russian patient cohort
publisher	Endocrinology Research Centre
publishDate	2009
url	https://doaj.org/article/5559038c5c01444990377c7ad5906eb9
work_keys_str_mv	AT marinavladimirovnashestakova improveobservationalprogramsafetyandeffectivenessofbiphasicinsulinaspart30inroutineclinicalpracticeoverviewofstartingcharacteristicsoftherussianpatientcohort AT akillballan improveobservationalprogramsafetyandeffectivenessofbiphasicinsulinaspart30inroutineclinicalpracticeoverviewofstartingcharacteristicsoftherussianpatientcohort
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IMPROVE observational program: safety and effectiveness of biphasic insulin aspart 30 in routine clinical practice. Overview of starting characteristics of the Russian patient cohort

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