Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation
Aromatase inhibitors are used to treat oestrogen receptor positive breast cancers but the molecular basis for the response of patients is unclear. Here, the authors use samples from an aromatase inhibitor clinical trial and show that tumours from poor responders have more mutations than good respond...
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Nature Portfolio
2016
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oai:doaj.org-article:555df6a99ecd4105b13f149fab06246c2021-12-02T15:34:56ZImpact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation10.1038/ncomms132942041-1723https://doaj.org/article/555df6a99ecd4105b13f149fab06246c2016-11-01T00:00:00Zhttps://doi.org/10.1038/ncomms13294https://doaj.org/toc/2041-1723Aromatase inhibitors are used to treat oestrogen receptor positive breast cancers but the molecular basis for the response of patients is unclear. Here, the authors use samples from an aromatase inhibitor clinical trial and show that tumours from poor responders have more mutations than good responders and also more frequently harbour p53 mutations.Pascal GellertCorrinne V. SegalQiong GaoElena López-KnowlesLesley-Ann MartinAndrew DodsonTiandao LiChristopher A. MillerCharles LuElaine R. MardisAlexa GillmanJames MordenManuela GrafKally SidhuAbigail EvansMichael ShereChristopher HolcombeStuart A. McIntoshNigel BundredAnthony SkeneWilliam MaxwellJohn RobertsonJudith M. BlissIan SmithMitch DowsettPOETIC Trial Management Group and TrialistsNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-11 (2016) |
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EN |
| topic |
Science Q |
| spellingShingle |
Science Q Pascal Gellert Corrinne V. Segal Qiong Gao Elena López-Knowles Lesley-Ann Martin Andrew Dodson Tiandao Li Christopher A. Miller Charles Lu Elaine R. Mardis Alexa Gillman James Morden Manuela Graf Kally Sidhu Abigail Evans Michael Shere Christopher Holcombe Stuart A. McIntosh Nigel Bundred Anthony Skene William Maxwell John Robertson Judith M. Bliss Ian Smith Mitch Dowsett POETIC Trial Management Group and Trialists Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation |
| description |
Aromatase inhibitors are used to treat oestrogen receptor positive breast cancers but the molecular basis for the response of patients is unclear. Here, the authors use samples from an aromatase inhibitor clinical trial and show that tumours from poor responders have more mutations than good responders and also more frequently harbour p53 mutations. |
| format |
article |
| author |
Pascal Gellert Corrinne V. Segal Qiong Gao Elena López-Knowles Lesley-Ann Martin Andrew Dodson Tiandao Li Christopher A. Miller Charles Lu Elaine R. Mardis Alexa Gillman James Morden Manuela Graf Kally Sidhu Abigail Evans Michael Shere Christopher Holcombe Stuart A. McIntosh Nigel Bundred Anthony Skene William Maxwell John Robertson Judith M. Bliss Ian Smith Mitch Dowsett POETIC Trial Management Group and Trialists |
| author_facet |
Pascal Gellert Corrinne V. Segal Qiong Gao Elena López-Knowles Lesley-Ann Martin Andrew Dodson Tiandao Li Christopher A. Miller Charles Lu Elaine R. Mardis Alexa Gillman James Morden Manuela Graf Kally Sidhu Abigail Evans Michael Shere Christopher Holcombe Stuart A. McIntosh Nigel Bundred Anthony Skene William Maxwell John Robertson Judith M. Bliss Ian Smith Mitch Dowsett POETIC Trial Management Group and Trialists |
| author_sort |
Pascal Gellert |
| title |
Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation |
| title_short |
Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation |
| title_full |
Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation |
| title_fullStr |
Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation |
| title_full_unstemmed |
Impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation |
| title_sort |
impact of mutational profiles on response of primary oestrogen receptor-positive breast cancers to oestrogen deprivation |
| publisher |
Nature Portfolio |
| publishDate |
2016 |
| url |
https://doaj.org/article/555df6a99ecd4105b13f149fab06246c |
| work_keys_str_mv |
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