Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism
Vps34 is a lipid kinase conserved from yeast to humans and involved in in intracellular vesicular trafficking and autophagy. Here Bilanges et al. show that inhibition of this kinase in mice improves glucose tolerance and diet-induced steatosis by modulating mitochondrial respiration and metabolism.
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Nature Portfolio
2017
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oai:doaj.org-article:555f2b0adcb149a18a070a3da30353202021-12-02T15:38:33ZVps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism10.1038/s41467-017-01969-42041-1723https://doaj.org/article/555f2b0adcb149a18a070a3da30353202017-11-01T00:00:00Zhttps://doi.org/10.1038/s41467-017-01969-4https://doaj.org/toc/2041-1723Vps34 is a lipid kinase conserved from yeast to humans and involved in in intracellular vesicular trafficking and autophagy. Here Bilanges et al. show that inhibition of this kinase in mice improves glucose tolerance and diet-induced steatosis by modulating mitochondrial respiration and metabolism.Benoit BilangesSamira AlliouacheneWayne PearceDaniele MorelliGyorgy SzabadkaiYuen-Li ChungGaëtan ChicanneColin ValetJulia M. HillPeter J. VosholLucy CollinsonChristopher PeddieKhaled AliEssam GhazalyVinothini RajeeveGeorgios TrichasShankar SrinivasClaire ChaussadeRachel S. SalamonJonathan M. BackerCheryl L. ScudamoreMaria A. WhiteheadErin P. KeaneyLeon O. MurphyRobert K. SempleBernard PayrastreSharon A. ToozeBart VanhaesebroeckNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-14 (2017) |
| institution |
DOAJ |
| collection |
DOAJ |
| language |
EN |
| topic |
Science Q |
| spellingShingle |
Science Q Benoit Bilanges Samira Alliouachene Wayne Pearce Daniele Morelli Gyorgy Szabadkai Yuen-Li Chung Gaëtan Chicanne Colin Valet Julia M. Hill Peter J. Voshol Lucy Collinson Christopher Peddie Khaled Ali Essam Ghazaly Vinothini Rajeeve Georgios Trichas Shankar Srinivas Claire Chaussade Rachel S. Salamon Jonathan M. Backer Cheryl L. Scudamore Maria A. Whitehead Erin P. Keaney Leon O. Murphy Robert K. Semple Bernard Payrastre Sharon A. Tooze Bart Vanhaesebroeck Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism |
| description |
Vps34 is a lipid kinase conserved from yeast to humans and involved in in intracellular vesicular trafficking and autophagy. Here Bilanges et al. show that inhibition of this kinase in mice improves glucose tolerance and diet-induced steatosis by modulating mitochondrial respiration and metabolism. |
| format |
article |
| author |
Benoit Bilanges Samira Alliouachene Wayne Pearce Daniele Morelli Gyorgy Szabadkai Yuen-Li Chung Gaëtan Chicanne Colin Valet Julia M. Hill Peter J. Voshol Lucy Collinson Christopher Peddie Khaled Ali Essam Ghazaly Vinothini Rajeeve Georgios Trichas Shankar Srinivas Claire Chaussade Rachel S. Salamon Jonathan M. Backer Cheryl L. Scudamore Maria A. Whitehead Erin P. Keaney Leon O. Murphy Robert K. Semple Bernard Payrastre Sharon A. Tooze Bart Vanhaesebroeck |
| author_facet |
Benoit Bilanges Samira Alliouachene Wayne Pearce Daniele Morelli Gyorgy Szabadkai Yuen-Li Chung Gaëtan Chicanne Colin Valet Julia M. Hill Peter J. Voshol Lucy Collinson Christopher Peddie Khaled Ali Essam Ghazaly Vinothini Rajeeve Georgios Trichas Shankar Srinivas Claire Chaussade Rachel S. Salamon Jonathan M. Backer Cheryl L. Scudamore Maria A. Whitehead Erin P. Keaney Leon O. Murphy Robert K. Semple Bernard Payrastre Sharon A. Tooze Bart Vanhaesebroeck |
| author_sort |
Benoit Bilanges |
| title |
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism |
| title_short |
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism |
| title_full |
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism |
| title_fullStr |
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism |
| title_full_unstemmed |
Vps34 PI 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism |
| title_sort |
vps34 pi 3-kinase inactivation enhances insulin sensitivity through reprogramming of mitochondrial metabolism |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/555f2b0adcb149a18a070a3da3035320 |
| work_keys_str_mv |
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