Starved epithelial cells uptake extracellular matrix for survival

Inhibition of PI3K/mTOR, which mimics nutrient starvation, causes death of detached but not matrix-attached cancer cells. Here the authors show that nutrient restriction of epithelial cells causes uptake of the matrix protein laminin, which results in increased intracellular amino acids and enhanced...

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Autores principales:	Taru Muranen, Marcin P. Iwanicki, Natasha L. Curry, Julie Hwang, Cory D. DuBois, Jonathan L. Coloff, Daniel S. Hitchcock, Clary B. Clish, Joan S. Brugge, Nada Y. Kalaany
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2017
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/556105391f034b16b025473af6af6511
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spelling	oai:doaj.org-article:556105391f034b16b025473af6af65112021-12-02T14:40:26ZStarved epithelial cells uptake extracellular matrix for survival10.1038/ncomms139892041-1723https://doaj.org/article/556105391f034b16b025473af6af65112017-01-01T00:00:00Zhttps://doi.org/10.1038/ncomms13989https://doaj.org/toc/2041-1723Inhibition of PI3K/mTOR, which mimics nutrient starvation, causes death of detached but not matrix-attached cancer cells. Here the authors show that nutrient restriction of epithelial cells causes uptake of the matrix protein laminin, which results in increased intracellular amino acids and enhanced mTORC1 signalling.Taru MuranenMarcin P. IwanickiNatasha L. CurryJulie HwangCory D. DuBoisJonathan L. ColoffDaniel S. HitchcockClary B. ClishJoan S. BruggeNada Y. KalaanyNature PortfolioarticleScienceQENNature Communications, Vol 8, Iss 1, Pp 1-12 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Taru Muranen Marcin P. Iwanicki Natasha L. Curry Julie Hwang Cory D. DuBois Jonathan L. Coloff Daniel S. Hitchcock Clary B. Clish Joan S. Brugge Nada Y. Kalaany Starved epithelial cells uptake extracellular matrix for survival
description	Inhibition of PI3K/mTOR, which mimics nutrient starvation, causes death of detached but not matrix-attached cancer cells. Here the authors show that nutrient restriction of epithelial cells causes uptake of the matrix protein laminin, which results in increased intracellular amino acids and enhanced mTORC1 signalling.
format	article
author	Taru Muranen Marcin P. Iwanicki Natasha L. Curry Julie Hwang Cory D. DuBois Jonathan L. Coloff Daniel S. Hitchcock Clary B. Clish Joan S. Brugge Nada Y. Kalaany
author_facet	Taru Muranen Marcin P. Iwanicki Natasha L. Curry Julie Hwang Cory D. DuBois Jonathan L. Coloff Daniel S. Hitchcock Clary B. Clish Joan S. Brugge Nada Y. Kalaany
author_sort	Taru Muranen
title	Starved epithelial cells uptake extracellular matrix for survival
title_short	Starved epithelial cells uptake extracellular matrix for survival
title_full	Starved epithelial cells uptake extracellular matrix for survival
title_fullStr	Starved epithelial cells uptake extracellular matrix for survival
title_full_unstemmed	Starved epithelial cells uptake extracellular matrix for survival
title_sort	starved epithelial cells uptake extracellular matrix for survival
publisher	Nature Portfolio
publishDate	2017
url	https://doaj.org/article/556105391f034b16b025473af6af6511
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Starved epithelial cells uptake extracellular matrix for survival

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