A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study

Radon is a major cause of lung cancer (LC) deaths among non-smokers worldwide. However, no serum biomarker for screening of LC risk in high residential radon (HRR) areas is available. Therefore, the aim of this study was to determine diagnostic values of serum carcinoembryonic antigen (CEA), cytoker...

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Autores principales:	Narongchai Autsavapromporn, Pitchayaponne Klunklin, Imjai Chitapanarux, Churdsak Jaikang, Busyamas Chewaskulyong, Patumrat Sripan, Masahiro Hosoda, Shinji Tokonami
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	radon serum biomarker lung cancer CEA Cyfra21-1 Science Q
Acceso en línea:	https://doaj.org/article/55622c4b472c46f0a45e036ced99b380
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spelling	oai:doaj.org-article:55622c4b472c46f0a45e036ced99b3802021-11-25T18:11:45ZA Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study10.3390/life111112732075-1729https://doaj.org/article/55622c4b472c46f0a45e036ced99b3802021-11-01T00:00:00Zhttps://www.mdpi.com/2075-1729/11/11/1273https://doaj.org/toc/2075-1729Radon is a major cause of lung cancer (LC) deaths among non-smokers worldwide. However, no serum biomarker for screening of LC risk in high residential radon (HRR) areas is available. Therefore, the aim of this study was to determine diagnostic values of serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (Cyfra21-1), human epididymis protein 4 (HE4), interleukin 8 (IL-8), migration inhibitory factor (MIF), tumor nuclear factor-alpha (TNF-α) and vascular endothelial growth factors (VEGF) occurring in high radon areas. Seventy-five LC non-smoker patients and seventy-five healthy controls (HC) were enrolled in this study. Among the HC groups, twenty-five HC were low residential radon (LRR) and fifty HC were HRR. Significantly higher (<i>p</i> < 0.0004) serum levels of CEA, Cyfra21-1, IL-8 and VEGF were found in the LC compared with the LRR and HRR groups. More importantly, significantly higher levels (<i>p</i> < 0.009) of serum CEA, Cyfra21-1 and IL-8 were observed in HRR compared with the LRR group. Likewise, a ROC curve demonstrated that serum CEA and Cyfra21-1 could better distinguish LC risk from HRR groups than IL-8. These results indicated that serum CEA and Cyfra21-1 were significantly increased in the HRR group and may be considered as potential biomarkers for individuals at high-risk to develop LC.Narongchai AutsavaprompornPitchayaponne KlunklinImjai ChitapanaruxChurdsak JaikangBusyamas ChewaskulyongPatumrat SripanMasahiro HosodaShinji TokonamiMDPI AGarticleradonserum biomarkerlung cancerCEACyfra21-1ScienceQENLife, Vol 11, Iss 1273, p 1273 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	radon serum biomarker lung cancer CEA Cyfra21-1 Science Q
spellingShingle	radon serum biomarker lung cancer CEA Cyfra21-1 Science Q Narongchai Autsavapromporn Pitchayaponne Klunklin Imjai Chitapanarux Churdsak Jaikang Busyamas Chewaskulyong Patumrat Sripan Masahiro Hosoda Shinji Tokonami A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study
description	Radon is a major cause of lung cancer (LC) deaths among non-smokers worldwide. However, no serum biomarker for screening of LC risk in high residential radon (HRR) areas is available. Therefore, the aim of this study was to determine diagnostic values of serum carcinoembryonic antigen (CEA), cytokeratin 19 fragment (Cyfra21-1), human epididymis protein 4 (HE4), interleukin 8 (IL-8), migration inhibitory factor (MIF), tumor nuclear factor-alpha (TNF-α) and vascular endothelial growth factors (VEGF) occurring in high radon areas. Seventy-five LC non-smoker patients and seventy-five healthy controls (HC) were enrolled in this study. Among the HC groups, twenty-five HC were low residential radon (LRR) and fifty HC were HRR. Significantly higher (<i>p</i> < 0.0004) serum levels of CEA, Cyfra21-1, IL-8 and VEGF were found in the LC compared with the LRR and HRR groups. More importantly, significantly higher levels (<i>p</i> < 0.009) of serum CEA, Cyfra21-1 and IL-8 were observed in HRR compared with the LRR group. Likewise, a ROC curve demonstrated that serum CEA and Cyfra21-1 could better distinguish LC risk from HRR groups than IL-8. These results indicated that serum CEA and Cyfra21-1 were significantly increased in the HRR group and may be considered as potential biomarkers for individuals at high-risk to develop LC.
format	article
author	Narongchai Autsavapromporn Pitchayaponne Klunklin Imjai Chitapanarux Churdsak Jaikang Busyamas Chewaskulyong Patumrat Sripan Masahiro Hosoda Shinji Tokonami
author_facet	Narongchai Autsavapromporn Pitchayaponne Klunklin Imjai Chitapanarux Churdsak Jaikang Busyamas Chewaskulyong Patumrat Sripan Masahiro Hosoda Shinji Tokonami
author_sort	Narongchai Autsavapromporn
title	A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study
title_short	A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study
title_full	A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study
title_fullStr	A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study
title_full_unstemmed	A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study
title_sort	potential serum biomarker for screening lung cancer risk in high level environmental radon areas: a pilot study
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/55622c4b472c46f0a45e036ced99b380
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A Potential Serum Biomarker for Screening Lung Cancer Risk in High Level Environmental Radon Areas: A Pilot Study

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