Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism

Objective. Irisin, a novel myokine, has recently been considered to produce a cardioprotective effect. Potential biomarkers for myocardial injuries in patients with severe hypothyroidism have yet to be identified. We aimed to investigate whether serum irisin may serve as a promising biomarker for ea...

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Autores principales:	Zhi Yao, Xiaoyu Ding, Xia Gao, Ning Yang, Yumei Jia, Jia Liu, Guang Wang
Formato:	article
Lenguaje:	EN
Publicado:	Hindawi Limited 2021
Materias:	Diseases of the endocrine glands. Clinical endocrinology RC648-665
Acceso en línea:	https://doaj.org/article/556416f13ef544dab7d62844081a7ac4
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spelling	oai:doaj.org-article:556416f13ef544dab7d62844081a7ac42021-11-29T00:56:35ZIrisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism1687-834510.1155/2021/3116068https://doaj.org/article/556416f13ef544dab7d62844081a7ac42021-01-01T00:00:00Zhttp://dx.doi.org/10.1155/2021/3116068https://doaj.org/toc/1687-8345Objective. Irisin, a novel myokine, has recently been considered to produce a cardioprotective effect. Potential biomarkers for myocardial injuries in patients with severe hypothyroidism have yet to be identified. We aimed to investigate whether serum irisin may serve as a promising biomarker for early detecting the myocardial injuries in patients with severe hypothyroidism. Methods. This cross-sectional study comprised 25 newly diagnosed drug-naive patients with severe primary hypothyroidism and 17 age- and sex-matched healthy controls. Circulating irisin levels and cardiac magnetic resonance (CMR) were evaluated in each participant. Left ventricular (LV) myocardial injuries were detected by CMR-based T1 mapping technique using a modified look-locker inversion recovery (MOLLI) sequence, which is quantified as native T1 values. Results. Compared with healthy controls, the severe hypothyroidism group had significantly lower levels of serum irisin, especially those with pericardial effusion (P<0.05). The severe hypothyroidism subjects exhibited lower peak filling rates (PFRs) and higher native myocardial T1 values than controls (P<0.05). Additionally, the ROC analysis displayed that the sensitivity and specificity of serum irisin for diagnosing pericardial effusion in patients with severe hypothyroidism were 73.3% and 100.0%, respectively. The AUC was 0.920 (0.861–1.000) (P<0.001). The cutoff value was 36.94 ng/mL. Moreover, the results in subgroup analysis revealed that the native T1 values of the low-irisin group were significantly higher than that of the high-irisin group (P<0.05). According to multivariate linear regression analysis, serum irisin concentrations were negatively and independently correlated with native myocardial T1 values after adjustment for age, sex, and other conventional confounding factors (β = −1.473, P<0.05). Conclusions. Irisin may be a potential biomarker for predicting myocardial injuries in patients with severe hypothyroidism.Zhi YaoXiaoyu DingXia GaoNing YangYumei JiaJia LiuGuang WangHindawi LimitedarticleDiseases of the endocrine glands. Clinical endocrinologyRC648-665ENInternational Journal of Endocrinology, Vol 2021 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Diseases of the endocrine glands. Clinical endocrinology RC648-665
spellingShingle	Diseases of the endocrine glands. Clinical endocrinology RC648-665 Zhi Yao Xiaoyu Ding Xia Gao Ning Yang Yumei Jia Jia Liu Guang Wang Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism
description	Objective. Irisin, a novel myokine, has recently been considered to produce a cardioprotective effect. Potential biomarkers for myocardial injuries in patients with severe hypothyroidism have yet to be identified. We aimed to investigate whether serum irisin may serve as a promising biomarker for early detecting the myocardial injuries in patients with severe hypothyroidism. Methods. This cross-sectional study comprised 25 newly diagnosed drug-naive patients with severe primary hypothyroidism and 17 age- and sex-matched healthy controls. Circulating irisin levels and cardiac magnetic resonance (CMR) were evaluated in each participant. Left ventricular (LV) myocardial injuries were detected by CMR-based T1 mapping technique using a modified look-locker inversion recovery (MOLLI) sequence, which is quantified as native T1 values. Results. Compared with healthy controls, the severe hypothyroidism group had significantly lower levels of serum irisin, especially those with pericardial effusion (P<0.05). The severe hypothyroidism subjects exhibited lower peak filling rates (PFRs) and higher native myocardial T1 values than controls (P<0.05). Additionally, the ROC analysis displayed that the sensitivity and specificity of serum irisin for diagnosing pericardial effusion in patients with severe hypothyroidism were 73.3% and 100.0%, respectively. The AUC was 0.920 (0.861–1.000) (P<0.001). The cutoff value was 36.94 ng/mL. Moreover, the results in subgroup analysis revealed that the native T1 values of the low-irisin group were significantly higher than that of the high-irisin group (P<0.05). According to multivariate linear regression analysis, serum irisin concentrations were negatively and independently correlated with native myocardial T1 values after adjustment for age, sex, and other conventional confounding factors (β = −1.473, P<0.05). Conclusions. Irisin may be a potential biomarker for predicting myocardial injuries in patients with severe hypothyroidism.
format	article
author	Zhi Yao Xiaoyu Ding Xia Gao Ning Yang Yumei Jia Jia Liu Guang Wang
author_facet	Zhi Yao Xiaoyu Ding Xia Gao Ning Yang Yumei Jia Jia Liu Guang Wang
author_sort	Zhi Yao
title	Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism
title_short	Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism
title_full	Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism
title_fullStr	Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism
title_full_unstemmed	Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism
title_sort	irisin as a potential biomarker associated with myocardial injuries in patients with severe hypothyroidism
publisher	Hindawi Limited
publishDate	2021
url	https://doaj.org/article/556416f13ef544dab7d62844081a7ac4
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_version_	1718407706839089152

Irisin as a Potential Biomarker Associated with Myocardial Injuries in Patients with Severe Hypothyroidism

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