3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles

Abstract The aim of this study was to explore the feasibility of using different 3D printed internal geometries as tablet formulations to obtain controlled release profiles. In order to obtain controllable release profiles, three types of tablet models (Cylinder, Horn and Reversed Horn) with control...

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Autores principales:	Xiaowen Xu, Jingzhou Zhao, Maonan Wang, Liang Wang, Junliang Yang
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/556460bb2f2c4e208675b294214e9c19
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spelling	oai:doaj.org-article:556460bb2f2c4e208675b294214e9c192021-12-02T15:08:31Z3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles10.1038/s41598-019-48921-82045-2322https://doaj.org/article/556460bb2f2c4e208675b294214e9c192019-08-01T00:00:00Zhttps://doi.org/10.1038/s41598-019-48921-8https://doaj.org/toc/2045-2322Abstract The aim of this study was to explore the feasibility of using different 3D printed internal geometries as tablet formulations to obtain controlled release profiles. In order to obtain controllable release profiles, three types of tablet models (Cylinder, Horn and Reversed Horn) with controlled structures were designed. The cylinder model shows a constant release profile and can keep the drug concentration within a certain range. The horn model exhibits an increasing release profile, which is suitable for the patients who have the drug resistance in the course of medication. The reversed horn model has a decreasing release profile that would be applied to hypertension cure. Furthermore, three types of tablets were fabricated successfully by a fused deposition modeling three-dimensional (3D) printer and injected with paracetamol (APAP) -containing gels. The results of in vitro drug release demonstrate that tablets with three kinds of structures can produce constant, gradually increasing, and gradually decreasing release profiles, respectively. The release attributes can be controlled by using different 3D printed geometries as tablet formulations. More importantly, there are no residues after dissolution. The method of preparing customized tablets with distinguished release profiles presented in this study has the promising potential in the fabrication of patient-tailored medicines.Xiaowen XuJingzhou ZhaoMaonan WangLiang WangJunliang YangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 9, Iss 1, Pp 1-8 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Xiaowen Xu Jingzhou Zhao Maonan Wang Liang Wang Junliang Yang 3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles
description	Abstract The aim of this study was to explore the feasibility of using different 3D printed internal geometries as tablet formulations to obtain controlled release profiles. In order to obtain controllable release profiles, three types of tablet models (Cylinder, Horn and Reversed Horn) with controlled structures were designed. The cylinder model shows a constant release profile and can keep the drug concentration within a certain range. The horn model exhibits an increasing release profile, which is suitable for the patients who have the drug resistance in the course of medication. The reversed horn model has a decreasing release profile that would be applied to hypertension cure. Furthermore, three types of tablets were fabricated successfully by a fused deposition modeling three-dimensional (3D) printer and injected with paracetamol (APAP) -containing gels. The results of in vitro drug release demonstrate that tablets with three kinds of structures can produce constant, gradually increasing, and gradually decreasing release profiles, respectively. The release attributes can be controlled by using different 3D printed geometries as tablet formulations. More importantly, there are no residues after dissolution. The method of preparing customized tablets with distinguished release profiles presented in this study has the promising potential in the fabrication of patient-tailored medicines.
format	article
author	Xiaowen Xu Jingzhou Zhao Maonan Wang Liang Wang Junliang Yang
author_facet	Xiaowen Xu Jingzhou Zhao Maonan Wang Liang Wang Junliang Yang
author_sort	Xiaowen Xu
title	3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles
title_short	3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles
title_full	3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles
title_fullStr	3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles
title_full_unstemmed	3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles
title_sort	3d printed polyvinyl alcohol tablets with multiple release profiles
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/556460bb2f2c4e208675b294214e9c19
work_keys_str_mv	AT xiaowenxu 3dprintedpolyvinylalcoholtabletswithmultiplereleaseprofiles AT jingzhouzhao 3dprintedpolyvinylalcoholtabletswithmultiplereleaseprofiles AT maonanwang 3dprintedpolyvinylalcoholtabletswithmultiplereleaseprofiles AT liangwang 3dprintedpolyvinylalcoholtabletswithmultiplereleaseprofiles AT junliangyang 3dprintedpolyvinylalcoholtabletswithmultiplereleaseprofiles
_version_	1718388058973274112

3D Printed Polyvinyl Alcohol Tablets with Multiple Release Profiles

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