Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

The ribosomal protein RPL10 is frequently mutated in T-cell acute lymphoblastic leukemia (T-ALL). Here, the authors show that it promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in turn modulates serine and glycine metabolism.

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Autores principales:	Kim R. Kampen, Laura Fancello, Tiziana Girardi, Gianmarco Rinaldi, Mélanie Planque, Sergey O. Sulima, Fabricio Loayza-Puch, Benno Verbelen, Stijn Vereecke, Jelle Verbeeck, Joyce Op de Beeck, Jonathan Royaert, Pieter Vermeersch, David Cassiman, Jan Cools, Reuven Agami, Mark Fiers, Sarah-Maria Fendt, Kim De Keersmaecker
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2019
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/556b5b4b144641dfbb1f4cc05deaa24e
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spelling	oai:doaj.org-article:556b5b4b144641dfbb1f4cc05deaa24e2021-12-02T14:38:41ZTranslatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells10.1038/s41467-019-10508-22041-1723https://doaj.org/article/556b5b4b144641dfbb1f4cc05deaa24e2019-06-01T00:00:00Zhttps://doi.org/10.1038/s41467-019-10508-2https://doaj.org/toc/2041-1723The ribosomal protein RPL10 is frequently mutated in T-cell acute lymphoblastic leukemia (T-ALL). Here, the authors show that it promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in turn modulates serine and glycine metabolism.Kim R. KampenLaura FancelloTiziana GirardiGianmarco RinaldiMélanie PlanqueSergey O. SulimaFabricio Loayza-PuchBenno VerbelenStijn VereeckeJelle VerbeeckJoyce Op de BeeckJonathan RoyaertPieter VermeerschDavid CassimanJan CoolsReuven AgamiMark FiersSarah-Maria FendtKim De KeersmaeckerNature PortfolioarticleScienceQENNature Communications, Vol 10, Iss 1, Pp 1-16 (2019)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Kim R. Kampen Laura Fancello Tiziana Girardi Gianmarco Rinaldi Mélanie Planque Sergey O. Sulima Fabricio Loayza-Puch Benno Verbelen Stijn Vereecke Jelle Verbeeck Joyce Op de Beeck Jonathan Royaert Pieter Vermeersch David Cassiman Jan Cools Reuven Agami Mark Fiers Sarah-Maria Fendt Kim De Keersmaecker Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells
description	The ribosomal protein RPL10 is frequently mutated in T-cell acute lymphoblastic leukemia (T-ALL). Here, the authors show that it promotes proliferation of T-ALL cells by upregulating the serine biosynthesis enzyme phosphoserine phosphatase which in turn modulates serine and glycine metabolism.
format	article
author	Kim R. Kampen Laura Fancello Tiziana Girardi Gianmarco Rinaldi Mélanie Planque Sergey O. Sulima Fabricio Loayza-Puch Benno Verbelen Stijn Vereecke Jelle Verbeeck Joyce Op de Beeck Jonathan Royaert Pieter Vermeersch David Cassiman Jan Cools Reuven Agami Mark Fiers Sarah-Maria Fendt Kim De Keersmaecker
author_facet	Kim R. Kampen Laura Fancello Tiziana Girardi Gianmarco Rinaldi Mélanie Planque Sergey O. Sulima Fabricio Loayza-Puch Benno Verbelen Stijn Vereecke Jelle Verbeeck Joyce Op de Beeck Jonathan Royaert Pieter Vermeersch David Cassiman Jan Cools Reuven Agami Mark Fiers Sarah-Maria Fendt Kim De Keersmaecker
author_sort	Kim R. Kampen
title	Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells
title_short	Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells
title_full	Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells
title_fullStr	Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells
title_full_unstemmed	Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells
title_sort	translatome analysis reveals altered serine and glycine metabolism in t-cell acute lymphoblastic leukemia cells
publisher	Nature Portfolio
publishDate	2019
url	https://doaj.org/article/556b5b4b144641dfbb1f4cc05deaa24e
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Translatome analysis reveals altered serine and glycine metabolism in T-cell acute lymphoblastic leukemia cells

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