A parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer
Abstract Forty-nine patients with stage IIb cervical cancer were included to investigate the changes in bladder volume in response to different approaches to maintaining consistent bladder filling. The impacts of age (P age), water consumption (P wat ), and body mass index (BMI, P bmi ) on the mean...
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Nature Portfolio
2017
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oai:doaj.org-article:556d01ccd9cf4f28a45dd49e1128e67e2021-12-02T12:32:15ZA parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer10.1038/s41598-017-00356-92045-2322https://doaj.org/article/556d01ccd9cf4f28a45dd49e1128e67e2017-03-01T00:00:00Zhttps://doi.org/10.1038/s41598-017-00356-9https://doaj.org/toc/2045-2322Abstract Forty-nine patients with stage IIb cervical cancer were included to investigate the changes in bladder volume in response to different approaches to maintaining consistent bladder filling. The impacts of age (P age), water consumption (P wat ), and body mass index (BMI, P bmi ) on the mean urinary inflow rate (v tot ) were analysed. The bladder volume (BV) increased linearly over time. A large variation in v tot among individuals was observed, ranging from 0.19 to 5.13 ml/min. The v tot was correlated with P age (R = −0.53, p = 0.01) and P wat (R = 0.84, p = 0.00), and no correlation between v tot and P bmi was found (p > 0.05). Therefore, v tot could be parameterized using two methods: multivariable linear regression and iterative fitting. There was no statistically significant difference between the two methods. The model accuracy was successfully assessed with several validation tests for patients with good compliance (79.2% of all patients), and the proportion of radiotherapy (RT) fractions with zero wait time (one ultrasound (US) scan) increased from 6.5% to 41.2%. The optimal US scanning number and RT time could be provided using this model. This adaptive RT approach could reduce patient discomfort caused by holding onto urine and reduce technician labour as well as cost.Fu JinHuan-Li LuoJuan ZhouDing-Yi YangLi YinXiao-Qing YangYa-Nan HeXian-Feng LiuDa QiuMing-Song ZhongHan YangChao LiQi-Cheng LiGuang-Lei HeYing WangNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 7, Iss 1, Pp 1-7 (2017) |
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Medicine R Science Q |
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Medicine R Science Q Fu Jin Huan-Li Luo Juan Zhou Ding-Yi Yang Li Yin Xiao-Qing Yang Ya-Nan He Xian-Feng Liu Da Qiu Ming-Song Zhong Han Yang Chao Li Qi-Cheng Li Guang-Lei He Ying Wang A parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer |
| description |
Abstract Forty-nine patients with stage IIb cervical cancer were included to investigate the changes in bladder volume in response to different approaches to maintaining consistent bladder filling. The impacts of age (P age), water consumption (P wat ), and body mass index (BMI, P bmi ) on the mean urinary inflow rate (v tot ) were analysed. The bladder volume (BV) increased linearly over time. A large variation in v tot among individuals was observed, ranging from 0.19 to 5.13 ml/min. The v tot was correlated with P age (R = −0.53, p = 0.01) and P wat (R = 0.84, p = 0.00), and no correlation between v tot and P bmi was found (p > 0.05). Therefore, v tot could be parameterized using two methods: multivariable linear regression and iterative fitting. There was no statistically significant difference between the two methods. The model accuracy was successfully assessed with several validation tests for patients with good compliance (79.2% of all patients), and the proportion of radiotherapy (RT) fractions with zero wait time (one ultrasound (US) scan) increased from 6.5% to 41.2%. The optimal US scanning number and RT time could be provided using this model. This adaptive RT approach could reduce patient discomfort caused by holding onto urine and reduce technician labour as well as cost. |
| format |
article |
| author |
Fu Jin Huan-Li Luo Juan Zhou Ding-Yi Yang Li Yin Xiao-Qing Yang Ya-Nan He Xian-Feng Liu Da Qiu Ming-Song Zhong Han Yang Chao Li Qi-Cheng Li Guang-Lei He Ying Wang |
| author_facet |
Fu Jin Huan-Li Luo Juan Zhou Ding-Yi Yang Li Yin Xiao-Qing Yang Ya-Nan He Xian-Feng Liu Da Qiu Ming-Song Zhong Han Yang Chao Li Qi-Cheng Li Guang-Lei He Ying Wang |
| author_sort |
Fu Jin |
| title |
A parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer |
| title_short |
A parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer |
| title_full |
A parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer |
| title_fullStr |
A parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer |
| title_full_unstemmed |
A parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer |
| title_sort |
parameterized model for mean urinary inflow rate and its preliminary application in radiotherapy for cervical cancer |
| publisher |
Nature Portfolio |
| publishDate |
2017 |
| url |
https://doaj.org/article/556d01ccd9cf4f28a45dd49e1128e67e |
| work_keys_str_mv |
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