Association of versican turnover with all-cause mortality in patients on haemodialysis.

<h4>Objective</h4>Cardiovascular diseases are among the most common causes of mortality in renal failure patients undergoing haemodialysis. A high turnover rate of the proteoglycan versican, represented by the increased presence of its fragmentation products in plasma, has previously bee...

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Autores principales:	Federica Genovese, Morten A Karsdal, Diana J Leeming, Alexandra Scholze, Martin Tepel
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5570623030694d4bbbec08f8bb321812
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spelling	oai:doaj.org-article:5570623030694d4bbbec08f8bb3218122021-11-25T05:55:05ZAssociation of versican turnover with all-cause mortality in patients on haemodialysis.1932-620310.1371/journal.pone.0111134https://doaj.org/article/5570623030694d4bbbec08f8bb3218122014-01-01T00:00:00Zhttps://doi.org/10.1371/journal.pone.0111134https://doaj.org/toc/1932-6203<h4>Objective</h4>Cardiovascular diseases are among the most common causes of mortality in renal failure patients undergoing haemodialysis. A high turnover rate of the proteoglycan versican, represented by the increased presence of its fragmentation products in plasma, has previously been associated with cardiovascular diseases. The objective of the study was to investigate the association of versican turnover assessed in plasma with survival in haemodialysis patients.<h4>Methods</h4>A specific matrix metalloproteinase-generated neo-epitope fragment of versican (VCANM) was measured in plasma of 364 haemodialysis patients with a 5-years follow-up, using a robust competitive enzyme-linked immunosorbent assays. Association between VCANM plasma concentration and survival was assessed by Kaplan-Meier analysis and adjusted Cox model.<h4>Results</h4>Haemodialysis patients with plasma VCANM concentrations in the lowest quartile had increased risk of death (odds ratio, as compared to the highest quartile: 7.1, p<0.001), with a reduced survival of 152 days compared to 1295 days for patients with plasma VCANM in the highest quartile. Multivariate analysis showed that low VCANM (p<0.001) and older age (p<0.001) predicted death in haemodialysis patients.<h4>Conclusions</h4>Low concentrations of the versican fragment VCANM in plasma were associated with higher risk of death among haemodialysis patients. A possible protective role for the examined versican fragment is suggested.Federica GenoveseMorten A KarsdalDiana J LeemingAlexandra ScholzeMartin TepelPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 10, p e111134 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Federica Genovese Morten A Karsdal Diana J Leeming Alexandra Scholze Martin Tepel Association of versican turnover with all-cause mortality in patients on haemodialysis.
description	<h4>Objective</h4>Cardiovascular diseases are among the most common causes of mortality in renal failure patients undergoing haemodialysis. A high turnover rate of the proteoglycan versican, represented by the increased presence of its fragmentation products in plasma, has previously been associated with cardiovascular diseases. The objective of the study was to investigate the association of versican turnover assessed in plasma with survival in haemodialysis patients.<h4>Methods</h4>A specific matrix metalloproteinase-generated neo-epitope fragment of versican (VCANM) was measured in plasma of 364 haemodialysis patients with a 5-years follow-up, using a robust competitive enzyme-linked immunosorbent assays. Association between VCANM plasma concentration and survival was assessed by Kaplan-Meier analysis and adjusted Cox model.<h4>Results</h4>Haemodialysis patients with plasma VCANM concentrations in the lowest quartile had increased risk of death (odds ratio, as compared to the highest quartile: 7.1, p<0.001), with a reduced survival of 152 days compared to 1295 days for patients with plasma VCANM in the highest quartile. Multivariate analysis showed that low VCANM (p<0.001) and older age (p<0.001) predicted death in haemodialysis patients.<h4>Conclusions</h4>Low concentrations of the versican fragment VCANM in plasma were associated with higher risk of death among haemodialysis patients. A possible protective role for the examined versican fragment is suggested.
format	article
author	Federica Genovese Morten A Karsdal Diana J Leeming Alexandra Scholze Martin Tepel
author_facet	Federica Genovese Morten A Karsdal Diana J Leeming Alexandra Scholze Martin Tepel
author_sort	Federica Genovese
title	Association of versican turnover with all-cause mortality in patients on haemodialysis.
title_short	Association of versican turnover with all-cause mortality in patients on haemodialysis.
title_full	Association of versican turnover with all-cause mortality in patients on haemodialysis.
title_fullStr	Association of versican turnover with all-cause mortality in patients on haemodialysis.
title_full_unstemmed	Association of versican turnover with all-cause mortality in patients on haemodialysis.
title_sort	association of versican turnover with all-cause mortality in patients on haemodialysis.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5570623030694d4bbbec08f8bb321812
work_keys_str_mv	AT federicagenovese associationofversicanturnoverwithallcausemortalityinpatientsonhaemodialysis AT mortenakarsdal associationofversicanturnoverwithallcausemortalityinpatientsonhaemodialysis AT dianajleeming associationofversicanturnoverwithallcausemortalityinpatientsonhaemodialysis AT alexandrascholze associationofversicanturnoverwithallcausemortalityinpatientsonhaemodialysis AT martintepel associationofversicanturnoverwithallcausemortalityinpatientsonhaemodialysis
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Association of versican turnover with all-cause mortality in patients on haemodialysis.

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