Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression

Some repressors down-regulate gene expression when they bind to a site up to 100 base pairs away from the nearest activator. Here, the authors show that this quenching-like repression can be achieved by the excluded volume effect when a DNA-bound protein alters the propensity of DNA to form a loop.

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Autores principales:	Michal Brunwasser-Meirom, Yaroslav Pollak, Sarah Goldberg, Lior Levy, Orna Atar, Roee Amit
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2016
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/557097a60f26479c91535bc7e20b92af
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spelling	oai:doaj.org-article:557097a60f26479c91535bc7e20b92af2021-12-02T16:49:42ZUsing synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression10.1038/ncomms104072041-1723https://doaj.org/article/557097a60f26479c91535bc7e20b92af2016-02-01T00:00:00Zhttps://doi.org/10.1038/ncomms10407https://doaj.org/toc/2041-1723Some repressors down-regulate gene expression when they bind to a site up to 100 base pairs away from the nearest activator. Here, the authors show that this quenching-like repression can be achieved by the excluded volume effect when a DNA-bound protein alters the propensity of DNA to form a loop.Michal Brunwasser-MeiromYaroslav PollakSarah GoldbergLior LevyOrna AtarRoee AmitNature PortfolioarticleScienceQENNature Communications, Vol 7, Iss 1, Pp 1-12 (2016)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Michal Brunwasser-Meirom Yaroslav Pollak Sarah Goldberg Lior Levy Orna Atar Roee Amit Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression
description	Some repressors down-regulate gene expression when they bind to a site up to 100 base pairs away from the nearest activator. Here, the authors show that this quenching-like repression can be achieved by the excluded volume effect when a DNA-bound protein alters the propensity of DNA to form a loop.
format	article
author	Michal Brunwasser-Meirom Yaroslav Pollak Sarah Goldberg Lior Levy Orna Atar Roee Amit
author_facet	Michal Brunwasser-Meirom Yaroslav Pollak Sarah Goldberg Lior Levy Orna Atar Roee Amit
author_sort	Michal Brunwasser-Meirom
title	Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression
title_short	Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression
title_full	Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression
title_fullStr	Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression
title_full_unstemmed	Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression
title_sort	using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression
publisher	Nature Portfolio
publishDate	2016
url	https://doaj.org/article/557097a60f26479c91535bc7e20b92af
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Using synthetic bacterial enhancers to reveal a looping-based mechanism for quenching-like repression

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