Targeting DNA Methylation in the Adult Brain through Diet

Metabolism and nutrition have a significant role in epigenetic modifications such as DNA methylation, which can influence gene expression. Recently, it has been suggested that bioactive nutrients and gut microbiota can alter DNA methylation in the central nervous system (CNS) through the gut–brain a...

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Autores principales:	Joseph Allison, Aleksandra Kaliszewska, Sara Uceda, Manuel Reiriz, Natalia Arias
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	DNA methylation brain microbiota nutrition cognition SAM Nutrition. Foods and food supply TX341-641
Acceso en línea:	https://doaj.org/article/557209744b0c4bce9a7f3c6c6d00d6bb
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id	oai:doaj.org-article:557209744b0c4bce9a7f3c6c6d00d6bb
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spelling	oai:doaj.org-article:557209744b0c4bce9a7f3c6c6d00d6bb2021-11-25T18:35:45ZTargeting DNA Methylation in the Adult Brain through Diet10.3390/nu131139792072-6643https://doaj.org/article/557209744b0c4bce9a7f3c6c6d00d6bb2021-11-01T00:00:00Zhttps://www.mdpi.com/2072-6643/13/11/3979https://doaj.org/toc/2072-6643Metabolism and nutrition have a significant role in epigenetic modifications such as DNA methylation, which can influence gene expression. Recently, it has been suggested that bioactive nutrients and gut microbiota can alter DNA methylation in the central nervous system (CNS) through the gut–brain axis, playing a crucial role in modulating CNS functions and, finally, behavior. Here, we will focus on the effect of metabolic signals in shaping brain DNA methylation during adulthood. We will provide an overview of potential interactions among diet, gastrointestinal microbiome and epigenetic alterations on brain methylation and behavior. In addition, the impact of different diet challenges on cytosine methylation dynamics in the adult brain will be discussed. Finally, we will explore new ways to modulate DNA hydroxymethylation, which is particularly abundant in neural tissue, through diet.Joseph AllisonAleksandra KaliszewskaSara UcedaManuel ReirizNatalia AriasMDPI AGarticleDNA methylationbrainmicrobiotanutritioncognitionSAMNutrition. Foods and food supplyTX341-641ENNutrients, Vol 13, Iss 3979, p 3979 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	DNA methylation brain microbiota nutrition cognition SAM Nutrition. Foods and food supply TX341-641
spellingShingle	DNA methylation brain microbiota nutrition cognition SAM Nutrition. Foods and food supply TX341-641 Joseph Allison Aleksandra Kaliszewska Sara Uceda Manuel Reiriz Natalia Arias Targeting DNA Methylation in the Adult Brain through Diet
description	Metabolism and nutrition have a significant role in epigenetic modifications such as DNA methylation, which can influence gene expression. Recently, it has been suggested that bioactive nutrients and gut microbiota can alter DNA methylation in the central nervous system (CNS) through the gut–brain axis, playing a crucial role in modulating CNS functions and, finally, behavior. Here, we will focus on the effect of metabolic signals in shaping brain DNA methylation during adulthood. We will provide an overview of potential interactions among diet, gastrointestinal microbiome and epigenetic alterations on brain methylation and behavior. In addition, the impact of different diet challenges on cytosine methylation dynamics in the adult brain will be discussed. Finally, we will explore new ways to modulate DNA hydroxymethylation, which is particularly abundant in neural tissue, through diet.
format	article
author	Joseph Allison Aleksandra Kaliszewska Sara Uceda Manuel Reiriz Natalia Arias
author_facet	Joseph Allison Aleksandra Kaliszewska Sara Uceda Manuel Reiriz Natalia Arias
author_sort	Joseph Allison
title	Targeting DNA Methylation in the Adult Brain through Diet
title_short	Targeting DNA Methylation in the Adult Brain through Diet
title_full	Targeting DNA Methylation in the Adult Brain through Diet
title_fullStr	Targeting DNA Methylation in the Adult Brain through Diet
title_full_unstemmed	Targeting DNA Methylation in the Adult Brain through Diet
title_sort	targeting dna methylation in the adult brain through diet
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/557209744b0c4bce9a7f3c6c6d00d6bb
work_keys_str_mv	AT josephallison targetingdnamethylationintheadultbrainthroughdiet AT aleksandrakaliszewska targetingdnamethylationintheadultbrainthroughdiet AT sarauceda targetingdnamethylationintheadultbrainthroughdiet AT manuelreiriz targetingdnamethylationintheadultbrainthroughdiet AT nataliaarias targetingdnamethylationintheadultbrainthroughdiet
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Targeting DNA Methylation in the Adult Brain through Diet

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