Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety

Abstract Maternal and environmental factors influence brain networks and architecture via both physiological pathways and epigenetic modifications. In particular, prenatal maternal depression and anxiety symptoms appear to impact infant white matter (WM) microstructure, leading us to investigate whe...

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Autores principales:	Douglas C. Dean, Andy Madrid, Elizabeth M. Planalp, Jason F. Moody, Ligia A. Papale, Karla M. Knobel, Elizabeth K. Wood, Ryan M. McAdams, Christopher L. Coe, H. Hill Goldsmith, Richard J. Davidson, Reid S. Alisch, Pamela J. Kling
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5576b2f149f8481a9b0c5d2362a5f10e
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spelling	oai:doaj.org-article:5576b2f149f8481a9b0c5d2362a5f10e2021-12-02T17:47:04ZCord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety10.1038/s41598-021-91642-02045-2322https://doaj.org/article/5576b2f149f8481a9b0c5d2362a5f10e2021-06-01T00:00:00Zhttps://doi.org/10.1038/s41598-021-91642-0https://doaj.org/toc/2045-2322Abstract Maternal and environmental factors influence brain networks and architecture via both physiological pathways and epigenetic modifications. In particular, prenatal maternal depression and anxiety symptoms appear to impact infant white matter (WM) microstructure, leading us to investigate whether epigenetic modifications (i.e., DNA methylation) contribute to these WM differences. To determine if infants of women with depression and anxiety symptoms exhibit epigenetic modifications linked to neurodevelopmental changes, 52 umbilical cord bloods (CBs) were profiled. We observed 219 differentially methylated genomic positions (DMPs; FDR p < 0.05) in CB that were associated with magnetic resonance imaging measures of WM microstructure at 1 month of age and in regions previously described to be related to maternal depression and anxiety symptoms. Genomic characterization of these associated DMPs revealed 143 unique genes with significant relationships to processes involved in neurodevelopment, GTPase activity, or the canonical Wnt signaling pathway. Separate regression models for female (n = 24) and male (n = 28) infants found 142 associated DMPs in females and 116 associated DMPs in males (nominal p value < 0.001, R > 0.5), which were annotated to 98 and 81 genes, respectively. Together, these findings suggest that umbilical CB DNA methylation levels at birth are associated with 1-month WM microstructure.Douglas C. DeanAndy MadridElizabeth M. PlanalpJason F. MoodyLigia A. PapaleKarla M. KnobelElizabeth K. WoodRyan M. McAdamsChristopher L. CoeH. Hill GoldsmithRichard J. DavidsonReid S. AlischPamela J. KlingNature PortfolioarticleMedicineRScienceQENScientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Douglas C. Dean Andy Madrid Elizabeth M. Planalp Jason F. Moody Ligia A. Papale Karla M. Knobel Elizabeth K. Wood Ryan M. McAdams Christopher L. Coe H. Hill Goldsmith Richard J. Davidson Reid S. Alisch Pamela J. Kling Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety
description	Abstract Maternal and environmental factors influence brain networks and architecture via both physiological pathways and epigenetic modifications. In particular, prenatal maternal depression and anxiety symptoms appear to impact infant white matter (WM) microstructure, leading us to investigate whether epigenetic modifications (i.e., DNA methylation) contribute to these WM differences. To determine if infants of women with depression and anxiety symptoms exhibit epigenetic modifications linked to neurodevelopmental changes, 52 umbilical cord bloods (CBs) were profiled. We observed 219 differentially methylated genomic positions (DMPs; FDR p < 0.05) in CB that were associated with magnetic resonance imaging measures of WM microstructure at 1 month of age and in regions previously described to be related to maternal depression and anxiety symptoms. Genomic characterization of these associated DMPs revealed 143 unique genes with significant relationships to processes involved in neurodevelopment, GTPase activity, or the canonical Wnt signaling pathway. Separate regression models for female (n = 24) and male (n = 28) infants found 142 associated DMPs in females and 116 associated DMPs in males (nominal p value < 0.001, R > 0.5), which were annotated to 98 and 81 genes, respectively. Together, these findings suggest that umbilical CB DNA methylation levels at birth are associated with 1-month WM microstructure.
format	article
author	Douglas C. Dean Andy Madrid Elizabeth M. Planalp Jason F. Moody Ligia A. Papale Karla M. Knobel Elizabeth K. Wood Ryan M. McAdams Christopher L. Coe H. Hill Goldsmith Richard J. Davidson Reid S. Alisch Pamela J. Kling
author_facet	Douglas C. Dean Andy Madrid Elizabeth M. Planalp Jason F. Moody Ligia A. Papale Karla M. Knobel Elizabeth K. Wood Ryan M. McAdams Christopher L. Coe H. Hill Goldsmith Richard J. Davidson Reid S. Alisch Pamela J. Kling
author_sort	Douglas C. Dean
title	Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety
title_short	Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety
title_full	Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety
title_fullStr	Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety
title_full_unstemmed	Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety
title_sort	cord blood dna methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5576b2f149f8481a9b0c5d2362a5f10e
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Cord blood DNA methylation modifications in infants are associated with white matter microstructure in the context of prenatal maternal depression and anxiety

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