Per-event probability of hepatitis C infection during sharing of injecting equipment.

<h4>Background</h4>Shared injecting apparatus during drug use is the premier risk factor for hepatitis C virus (HCV) transmission.<h4>Aims</h4>To estimate the per-event probability of HCV infection during a sharing event, and the transmission probability of HCV from contamina...

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Autores principales:	Lies Boelen, Suzy Teutsch, David P Wilson, Kate Dolan, Greg J Dore, Andrew R Lloyd, Fabio Luciani, HITS investigators
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/5579b95741fc444bba7ff4576e9517f3
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spelling	oai:doaj.org-article:5579b95741fc444bba7ff4576e9517f32021-11-25T06:09:28ZPer-event probability of hepatitis C infection during sharing of injecting equipment.1932-620310.1371/journal.pone.0100749https://doaj.org/article/5579b95741fc444bba7ff4576e9517f32014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/25000496/?tool=EBIhttps://doaj.org/toc/1932-6203<h4>Background</h4>Shared injecting apparatus during drug use is the premier risk factor for hepatitis C virus (HCV) transmission.<h4>Aims</h4>To estimate the per-event probability of HCV infection during a sharing event, and the transmission probability of HCV from contaminated injecting apparatus.<h4>Methods</h4>Estimates were obtained using a maximum likelihood method with estimated IDU and sharing events obtained from behavioural data.<h4>Settings</h4>Cohort study in multiple correction centres in New South Wales, Australia.<h4>Participants</h4>Subjects (N = 500) with a lifetime history of injecting drug use (IDU) who were followed up between 2005 and 2012. During follow-up, interviews for risk behaviours were taken and blood sampling (HCV-antibody and RNA testing) was performed.<h4>Measurements</h4>Self-reported frequencies of injecting drugs and sharing events, as well as other risk behaviours and details on the nature of injecting events.<h4>Findings</h4>The best estimate of the per-event probability of infection was 0.57% (CI: 0.32-1.05%). A sensitivity analysis on the likely effect of under-reporting of sharing of the injecting apparatus indicated that the per event infection probability may be as low as 0.17% (95% CI: 0.11%-0.25%). The transmission probability was similarly shown to range up to 6%, dependent on the presumed prevalence of the virus in injecting equipment.<h4>Conclusions</h4>The transmission probability of HCV during a sharing event is small. Hence, strategies to reduce the frequency and sharing of injecting equipment are required, as well as interventions focused on decreasing the per event risk.Lies BoelenSuzy TeutschDavid P WilsonKate DolanGreg J DoreAndrew R LloydFabio LucianiHITS investigatorsPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 7, p e100749 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Lies Boelen Suzy Teutsch David P Wilson Kate Dolan Greg J Dore Andrew R Lloyd Fabio Luciani HITS investigators Per-event probability of hepatitis C infection during sharing of injecting equipment.
description	<h4>Background</h4>Shared injecting apparatus during drug use is the premier risk factor for hepatitis C virus (HCV) transmission.<h4>Aims</h4>To estimate the per-event probability of HCV infection during a sharing event, and the transmission probability of HCV from contaminated injecting apparatus.<h4>Methods</h4>Estimates were obtained using a maximum likelihood method with estimated IDU and sharing events obtained from behavioural data.<h4>Settings</h4>Cohort study in multiple correction centres in New South Wales, Australia.<h4>Participants</h4>Subjects (N = 500) with a lifetime history of injecting drug use (IDU) who were followed up between 2005 and 2012. During follow-up, interviews for risk behaviours were taken and blood sampling (HCV-antibody and RNA testing) was performed.<h4>Measurements</h4>Self-reported frequencies of injecting drugs and sharing events, as well as other risk behaviours and details on the nature of injecting events.<h4>Findings</h4>The best estimate of the per-event probability of infection was 0.57% (CI: 0.32-1.05%). A sensitivity analysis on the likely effect of under-reporting of sharing of the injecting apparatus indicated that the per event infection probability may be as low as 0.17% (95% CI: 0.11%-0.25%). The transmission probability was similarly shown to range up to 6%, dependent on the presumed prevalence of the virus in injecting equipment.<h4>Conclusions</h4>The transmission probability of HCV during a sharing event is small. Hence, strategies to reduce the frequency and sharing of injecting equipment are required, as well as interventions focused on decreasing the per event risk.
format	article
author	Lies Boelen Suzy Teutsch David P Wilson Kate Dolan Greg J Dore Andrew R Lloyd Fabio Luciani HITS investigators
author_facet	Lies Boelen Suzy Teutsch David P Wilson Kate Dolan Greg J Dore Andrew R Lloyd Fabio Luciani HITS investigators
author_sort	Lies Boelen
title	Per-event probability of hepatitis C infection during sharing of injecting equipment.
title_short	Per-event probability of hepatitis C infection during sharing of injecting equipment.
title_full	Per-event probability of hepatitis C infection during sharing of injecting equipment.
title_fullStr	Per-event probability of hepatitis C infection during sharing of injecting equipment.
title_full_unstemmed	Per-event probability of hepatitis C infection during sharing of injecting equipment.
title_sort	per-event probability of hepatitis c infection during sharing of injecting equipment.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/5579b95741fc444bba7ff4576e9517f3
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Per-event probability of hepatitis C infection during sharing of injecting equipment.

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