Motor recruitment to the TIM23 channel’s lateral gate restricts polypeptide release into the inner membrane

The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane. Here authors show that the import motor J-protein Pam18 controls lateral protein release into the lipid bilayer.

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Detalles Bibliográficos
Autores principales: Alexander Benjamin Schendzielorz, Piotr Bragoszewski, Nataliia Naumenko, Ridhima Gomkale, Christian Schulz, Bernard Guiard, Agnieszka Chacinska, Peter Rehling
Formato: article
Lenguaje:EN
Publicado: Nature Portfolio 2018
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Acceso en línea:https://doaj.org/article/5579f2342b364cb2902c5d7d5fcf3a26
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Sumario:The mitochondrial TIM23-complex facilitates anterograde precursor transport across the inner membrane into the matrix and lateral release of precursors into the membrane. Here authors show that the import motor J-protein Pam18 controls lateral protein release into the lipid bilayer.