Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene

Background. Gestational diabetes (GDM) due to GCK gene mutations is the most frequent form of monogenic diabetes mellitus (DM) presenting during pregnancy. It has been suggested that the use of insulin in pregnancies with fetuses carrying GCK mutations may lead to intrauterine growth retardation. In...

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Autores principales:	Natalia A. Zubkova, Fatima F. Burumkulova, Victoria I. Ulyatovskaya, Vasily A. Petrukhin, Margarita A. Plechanova, Anton E. Panov, Tatiana S. Budykina, Nina A. Makretskaya, Anatoly N. Tiulpakov
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2018
Materias:	gestational diabetes mellitus glucokinase macrosomia insulin therapy Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/557c1bf520764d839512b24c2933c76a
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spelling	oai:doaj.org-article:557c1bf520764d839512b24c2933c76a2021-11-14T09:00:21ZBirth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene2072-03512072-037810.14341/DM9429https://doaj.org/article/557c1bf520764d839512b24c2933c76a2018-05-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/9429https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Background. Gestational diabetes (GDM) due to GCK gene mutations is the most frequent form of monogenic diabetes mellitus (DM) presenting during pregnancy. It has been suggested that the use of insulin in pregnancies with fetuses carrying GCK mutations may lead to intrauterine growth retardation. In the present study we evaluated the effect of insulin therapy during pregnancy on birth weight and length in the offsprings of mothers with GDM due to GCK mutations. Aims. The aim was to study birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK, depending on the therapy during pregnancy. Materials and methods. The study included 38 patients with GDM caused by GCK gene mutations (18.7%) and the 45 offsprings. To define molecular basis of GDM in pregnant women we used a targeted NGS. ‘Diabetes panel’ genes were sequenced using a custom Ion Ampliseq gene panel and PGM semiconductor sequencer (Ion Torrent). To found the same mutations in their offsprings was used Sanger sequencing. All children were divided into 3 groups depending of their genotype and therapy received by the mothers during pregnancy. Results. We found statistically significant differences in birth length (p=0.04) and weight (p=0,031) depending on the genotype of the child and therapy in the mother. The risk of macrosomia was shown in non-mutation-carrying offsprings only. The birth weight in children with GCK gene mutations whose mothers received insulin during pregnancy was significantly lower. However, the birth weight remained in the normal range. Conclusions. Since prenatal diagnostics in the mothers with GCK gene mutations is not always justified, we recommend insulin therapy in order to prevent fetal macrosomia, which, however, should be less aggressive than in GDM due to other causes.Natalia A. ZubkovaFatima F. BurumkulovaVictoria I. UlyatovskayaVasily A. PetrukhinMargarita A. PlechanovaAnton E. PanovTatiana S. BudykinaNina A. MakretskayaAnatoly N. TiulpakovEndocrinology Research Centrearticlegestational diabetes mellitusglucokinasemacrosomiainsulin therapyNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 21, Iss 2, Pp 92-98 (2018)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	gestational diabetes mellitus glucokinase macrosomia insulin therapy Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	gestational diabetes mellitus glucokinase macrosomia insulin therapy Nutritional diseases. Deficiency diseases RC620-627 Natalia A. Zubkova Fatima F. Burumkulova Victoria I. Ulyatovskaya Vasily A. Petrukhin Margarita A. Plechanova Anton E. Panov Tatiana S. Budykina Nina A. Makretskaya Anatoly N. Tiulpakov Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene
description	Background. Gestational diabetes (GDM) due to GCK gene mutations is the most frequent form of monogenic diabetes mellitus (DM) presenting during pregnancy. It has been suggested that the use of insulin in pregnancies with fetuses carrying GCK mutations may lead to intrauterine growth retardation. In the present study we evaluated the effect of insulin therapy during pregnancy on birth weight and length in the offsprings of mothers with GDM due to GCK mutations. Aims. The aim was to study birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK, depending on the therapy during pregnancy. Materials and methods. The study included 38 patients with GDM caused by GCK gene mutations (18.7%) and the 45 offsprings. To define molecular basis of GDM in pregnant women we used a targeted NGS. ‘Diabetes panel’ genes were sequenced using a custom Ion Ampliseq gene panel and PGM semiconductor sequencer (Ion Torrent). To found the same mutations in their offsprings was used Sanger sequencing. All children were divided into 3 groups depending of their genotype and therapy received by the mothers during pregnancy. Results. We found statistically significant differences in birth length (p=0.04) and weight (p=0,031) depending on the genotype of the child and therapy in the mother. The risk of macrosomia was shown in non-mutation-carrying offsprings only. The birth weight in children with GCK gene mutations whose mothers received insulin during pregnancy was significantly lower. However, the birth weight remained in the normal range. Conclusions. Since prenatal diagnostics in the mothers with GCK gene mutations is not always justified, we recommend insulin therapy in order to prevent fetal macrosomia, which, however, should be less aggressive than in GDM due to other causes.
format	article
author	Natalia A. Zubkova Fatima F. Burumkulova Victoria I. Ulyatovskaya Vasily A. Petrukhin Margarita A. Plechanova Anton E. Panov Tatiana S. Budykina Nina A. Makretskaya Anatoly N. Tiulpakov
author_facet	Natalia A. Zubkova Fatima F. Burumkulova Victoria I. Ulyatovskaya Vasily A. Petrukhin Margarita A. Plechanova Anton E. Panov Tatiana S. Budykina Nina A. Makretskaya Anatoly N. Tiulpakov
author_sort	Natalia A. Zubkova
title	Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene
title_short	Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene
title_full	Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene
title_fullStr	Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene
title_full_unstemmed	Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene
title_sort	birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in gck gene
publisher	Endocrinology Research Centre
publishDate	2018
url	https://doaj.org/article/557c1bf520764d839512b24c2933c76a
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Birth weight and length in offsprings of mothers with gestational diabetes mellitus due to mutations in GCK gene

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