Risk factors associated with human immunodeficiency virus infection in blood donors in Iran: A case–control study

BACKGROUND: Despite setting the stringent criteria for the selection of safe donors, some human immunodeficiency virus (HIV)-positive volunteers manage to give blood. Considering the window period of screening tests, this could endanger the safety of blood supply.MATERIALS AND METHODS: A frequency m...

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Autores principales:	Fariba Seighali, Nasim Sadat Hosseini Divkolaye, Negar Rezaei, Masumeh Kangarloo
Formato:	article
Lenguaje:	EN
Publicado:	Wolters Kluwer Medknow Publications 2021
Materias:	blood donors human immunodeficiency virus iran risk factor Diseases of the blood and blood-forming organs RC633-647.5
Acceso en línea:	https://doaj.org/article/557d3f15733e4b9f890be4c262c4ce28
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spelling	oai:doaj.org-article:557d3f15733e4b9f890be4c262c4ce282021-11-12T10:08:28ZRisk factors associated with human immunodeficiency virus infection in blood donors in Iran: A case–control study0973-62471998-356510.4103/ajts.AJTS_47_18https://doaj.org/article/557d3f15733e4b9f890be4c262c4ce282021-01-01T00:00:00Zhttp://www.ajts.org/article.asp?issn=0973-6247;year=2021;volume=15;issue=2;spage=183;epage=188;aulast=Seighalihttps://doaj.org/toc/0973-6247https://doaj.org/toc/1998-3565BACKGROUND: Despite setting the stringent criteria for the selection of safe donors, some human immunodeficiency virus (HIV)-positive volunteers manage to give blood. Considering the window period of screening tests, this could endanger the safety of blood supply.MATERIALS AND METHODS: A frequency match case–control study was conducted on HIV-positive and negative blood donors in Iran from 2007 to 2008. Overall, 61 HIV-positive and 224 HIV-negative blood donors were selected as cases and controls, respectively. Two groups were matched for confounding factors. An identical questionnaire was used to assess risk factors. Univariate regression analysis for calculating crude odds ratio (OR) and 95% confidence interval (CI) was used for detecting eligibility of risk factors to enter the final model. The exposures with P < 0.1 were entered in the logistic regression model. Adjusted ORs with P < 0.05 and 95% CIs were reported for statistically significant variables.RESULTS: Significant effects were detected for the following variables: education, job, tattoo, intravenous (IV) drug abuse, imprisonment, and risky sexual behavior. However, based on multiple analyses, education, IV drug abuse, imprisonment, and risky sexual behavior remain significant.CONCLUSION: The majority of our findings are in parallel with the other studies performed in other countries. To increase blood safety, special attention should be paid to illiterate, first-time blood donors who are in the 25–40 age range. In addition, having the history of IV drug abuse, imprisonment and risky sexual behaviors put the blood donors more at risk of infecting HIV.Fariba SeighaliNasim Sadat Hosseini DivkolayeNegar RezaeiMasumeh KangarlooWolters Kluwer Medknow Publicationsarticleblood donorshuman immunodeficiency virusiranrisk factorDiseases of the blood and blood-forming organsRC633-647.5ENAsian Journal of Transfusion Science, Vol 15, Iss 2, Pp 183-188 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	blood donors human immunodeficiency virus iran risk factor Diseases of the blood and blood-forming organs RC633-647.5
spellingShingle	blood donors human immunodeficiency virus iran risk factor Diseases of the blood and blood-forming organs RC633-647.5 Fariba Seighali Nasim Sadat Hosseini Divkolaye Negar Rezaei Masumeh Kangarloo Risk factors associated with human immunodeficiency virus infection in blood donors in Iran: A case–control study
description	BACKGROUND: Despite setting the stringent criteria for the selection of safe donors, some human immunodeficiency virus (HIV)-positive volunteers manage to give blood. Considering the window period of screening tests, this could endanger the safety of blood supply.MATERIALS AND METHODS: A frequency match case–control study was conducted on HIV-positive and negative blood donors in Iran from 2007 to 2008. Overall, 61 HIV-positive and 224 HIV-negative blood donors were selected as cases and controls, respectively. Two groups were matched for confounding factors. An identical questionnaire was used to assess risk factors. Univariate regression analysis for calculating crude odds ratio (OR) and 95% confidence interval (CI) was used for detecting eligibility of risk factors to enter the final model. The exposures with P < 0.1 were entered in the logistic regression model. Adjusted ORs with P < 0.05 and 95% CIs were reported for statistically significant variables.RESULTS: Significant effects were detected for the following variables: education, job, tattoo, intravenous (IV) drug abuse, imprisonment, and risky sexual behavior. However, based on multiple analyses, education, IV drug abuse, imprisonment, and risky sexual behavior remain significant.CONCLUSION: The majority of our findings are in parallel with the other studies performed in other countries. To increase blood safety, special attention should be paid to illiterate, first-time blood donors who are in the 25–40 age range. In addition, having the history of IV drug abuse, imprisonment and risky sexual behaviors put the blood donors more at risk of infecting HIV.
format	article
author	Fariba Seighali Nasim Sadat Hosseini Divkolaye Negar Rezaei Masumeh Kangarloo
author_facet	Fariba Seighali Nasim Sadat Hosseini Divkolaye Negar Rezaei Masumeh Kangarloo
author_sort	Fariba Seighali
title	Risk factors associated with human immunodeficiency virus infection in blood donors in Iran: A case–control study
title_short	Risk factors associated with human immunodeficiency virus infection in blood donors in Iran: A case–control study
title_full	Risk factors associated with human immunodeficiency virus infection in blood donors in Iran: A case–control study
title_fullStr	Risk factors associated with human immunodeficiency virus infection in blood donors in Iran: A case–control study
title_full_unstemmed	Risk factors associated with human immunodeficiency virus infection in blood donors in Iran: A case–control study
title_sort	risk factors associated with human immunodeficiency virus infection in blood donors in iran: a case–control study
publisher	Wolters Kluwer Medknow Publications
publishDate	2021
url	https://doaj.org/article/557d3f15733e4b9f890be4c262c4ce28
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Risk factors associated with human immunodeficiency virus infection in blood donors in Iran: A case–control study

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