Acute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.

The purpose of the study was to highlight the acute motor reflex adaptation and to deepen functional deficits following a middle cerebral artery occlusion-reperfusion (MCAO-r). Thirty-six Sprague-Dawley rats were included in this study. The middle cerebral artery occlusion (MCAO; 120 min) was perfor...

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Autores principales:	Caroline Pin-Barre, Jérôme Laurin, Marie-Solenne Felix, Vincent Pertici, Frank Kober, Tanguy Marqueste, Valery Matarazzo, Françoise Muscatelli-Bossy, Jean-Jacques Temprado, Jeanick Brisswalter, Patrick Decherchi
Formato:	article
Lenguaje:	EN
Publicado:	Public Library of Science (PLoS) 2014
Materias:	Medicine R Science Q
Acceso en línea:	https://doaj.org/article/55836339722b49438765fef38f1e22f6
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spelling	oai:doaj.org-article:55836339722b49438765fef38f1e22f62021-11-18T08:30:27ZAcute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.1932-620310.1371/journal.pone.0089953https://doaj.org/article/55836339722b49438765fef38f1e22f62014-01-01T00:00:00Zhttps://www.ncbi.nlm.nih.gov/pmc/articles/pmid/24587147/?tool=EBIhttps://doaj.org/toc/1932-6203The purpose of the study was to highlight the acute motor reflex adaptation and to deepen functional deficits following a middle cerebral artery occlusion-reperfusion (MCAO-r). Thirty-six Sprague-Dawley rats were included in this study. The middle cerebral artery occlusion (MCAO; 120 min) was performed on 16 rats studied at 1 and 7 days, respectively (MCAO-D1 and MCAO-D7, n = 8 for each group). The other animals were divided into 3 groups: SHAM-D1 (n = 6), SHAM-D7 (n = 6) and Control (n = 8). Rats performed 4 behavioral tests (the elevated body swing test, the beam balance test, the ladder-climbing test and the forelimb grip force) before the surgery and daily after MCAO-r. H-reflex on triceps brachii was measured before and after isometric exercise. Infarction size and cerebral edema were respectively assessed by histological (Cresyl violet) and MRI measurements at the same time points than H-reflex recordings. Animals with cerebral ischemia showed persistent functional deficits during the first week post-MCAO-r. H-reflex was not decreased in response to isometric exercise one day after the cerebral ischemia contrary to the other groups. The motor reflex regulation was recovered 7 days post-MCAO-r. This result reflects an acute sensorimotor adaptation at the spinal level after MCAO-r.Caroline Pin-BarreJérôme LaurinMarie-Solenne FelixVincent PerticiFrank KoberTanguy MarquesteValery MatarazzoFrançoise Muscatelli-BossyJean-Jacques TempradoJeanick BrisswalterPatrick DecherchiPublic Library of Science (PLoS)articleMedicineRScienceQENPLoS ONE, Vol 9, Iss 2, p e89953 (2014)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine R Science Q
spellingShingle	Medicine R Science Q Caroline Pin-Barre Jérôme Laurin Marie-Solenne Felix Vincent Pertici Frank Kober Tanguy Marqueste Valery Matarazzo Françoise Muscatelli-Bossy Jean-Jacques Temprado Jeanick Brisswalter Patrick Decherchi Acute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.
description	The purpose of the study was to highlight the acute motor reflex adaptation and to deepen functional deficits following a middle cerebral artery occlusion-reperfusion (MCAO-r). Thirty-six Sprague-Dawley rats were included in this study. The middle cerebral artery occlusion (MCAO; 120 min) was performed on 16 rats studied at 1 and 7 days, respectively (MCAO-D1 and MCAO-D7, n = 8 for each group). The other animals were divided into 3 groups: SHAM-D1 (n = 6), SHAM-D7 (n = 6) and Control (n = 8). Rats performed 4 behavioral tests (the elevated body swing test, the beam balance test, the ladder-climbing test and the forelimb grip force) before the surgery and daily after MCAO-r. H-reflex on triceps brachii was measured before and after isometric exercise. Infarction size and cerebral edema were respectively assessed by histological (Cresyl violet) and MRI measurements at the same time points than H-reflex recordings. Animals with cerebral ischemia showed persistent functional deficits during the first week post-MCAO-r. H-reflex was not decreased in response to isometric exercise one day after the cerebral ischemia contrary to the other groups. The motor reflex regulation was recovered 7 days post-MCAO-r. This result reflects an acute sensorimotor adaptation at the spinal level after MCAO-r.
format	article
author	Caroline Pin-Barre Jérôme Laurin Marie-Solenne Felix Vincent Pertici Frank Kober Tanguy Marqueste Valery Matarazzo Françoise Muscatelli-Bossy Jean-Jacques Temprado Jeanick Brisswalter Patrick Decherchi
author_facet	Caroline Pin-Barre Jérôme Laurin Marie-Solenne Felix Vincent Pertici Frank Kober Tanguy Marqueste Valery Matarazzo Françoise Muscatelli-Bossy Jean-Jacques Temprado Jeanick Brisswalter Patrick Decherchi
author_sort	Caroline Pin-Barre
title	Acute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.
title_short	Acute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.
title_full	Acute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.
title_fullStr	Acute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.
title_full_unstemmed	Acute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.
title_sort	acute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.
publisher	Public Library of Science (PLoS)
publishDate	2014
url	https://doaj.org/article/55836339722b49438765fef38f1e22f6
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Acute neuromuscular adaptation at the spinal level following middle cerebral artery occlusion-reperfusion in the rat.

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