Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea

Equine parvovirus-hepatitis (EqPV-H) causes equine hepatitis. The prevalence of EqPV-H in healthy horses has been reported in the United States, China, Germany, and Austria. The present study determined the prevalence of EqPV-H in the sera of clinically healthy horses in South Korea to identify the...

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Autores principales:	Sang-Kyu Lee, Dongsun Park, Inhyung Lee
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	EqPV-H prevalence molecular prevalence phylogenetic analysis South Korea Veterinary medicine SF600-1100
Acceso en línea:	https://doaj.org/article/55862ab412284206a8b3db10812aa73c
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spelling	oai:doaj.org-article:55862ab412284206a8b3db10812aa73c2021-11-25T19:12:09ZMolecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea10.3390/vetsci81102822306-7381https://doaj.org/article/55862ab412284206a8b3db10812aa73c2021-11-01T00:00:00Zhttps://www.mdpi.com/2306-7381/8/11/282https://doaj.org/toc/2306-7381Equine parvovirus-hepatitis (EqPV-H) causes equine hepatitis. The prevalence of EqPV-H in healthy horses has been reported in the United States, China, Germany, and Austria. The present study determined the prevalence of EqPV-H in the sera of clinically healthy horses in South Korea to identify the potential factors for infection and examine the genetic diversity of EqPV-H DNA sequences through comparison with foreign strains. Serum samples collected from 321 horses were tested for EqPV-H using non-structural protein 1 (NS1)-specific polymerase chain reaction. The associations of EqPV-H infection with sex, age, aspartate aminotransferase and γ-glutamyl transferase levels, and race performance were analyzed. Fourteen samples tested positive for EqPV-H (4.4%, 14/321), and EqPV-H infection was associated with sex (<i>p</i> = 0.006) and performance (<i>p</i> = 0.049). In both EqPV-H-positive and control horses, liver-specific biochemical analytes were within the normal ranges. Phylogenetic analyses based on the partial sequences of EqPV-H NS1 revealed that the Korean EqPV-H isolates shared approximately 98.7–100% similarity. Of these, 11 Korean isolates shared high similarity with strains from the United States, Germany, and China, and the remaining three strains were distinct in phylogenetic analyses. The present study describes the current molecular prevalence, potential risk factors, and genetic diversity of Korean EqPV-H.Sang-Kyu LeeDongsun ParkInhyung LeeMDPI AGarticleEqPV-Hprevalencemolecular prevalencephylogenetic analysisSouth KoreaVeterinary medicineSF600-1100ENVeterinary Sciences, Vol 8, Iss 282, p 282 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	EqPV-H prevalence molecular prevalence phylogenetic analysis South Korea Veterinary medicine SF600-1100
spellingShingle	EqPV-H prevalence molecular prevalence phylogenetic analysis South Korea Veterinary medicine SF600-1100 Sang-Kyu Lee Dongsun Park Inhyung Lee Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea
description	Equine parvovirus-hepatitis (EqPV-H) causes equine hepatitis. The prevalence of EqPV-H in healthy horses has been reported in the United States, China, Germany, and Austria. The present study determined the prevalence of EqPV-H in the sera of clinically healthy horses in South Korea to identify the potential factors for infection and examine the genetic diversity of EqPV-H DNA sequences through comparison with foreign strains. Serum samples collected from 321 horses were tested for EqPV-H using non-structural protein 1 (NS1)-specific polymerase chain reaction. The associations of EqPV-H infection with sex, age, aspartate aminotransferase and γ-glutamyl transferase levels, and race performance were analyzed. Fourteen samples tested positive for EqPV-H (4.4%, 14/321), and EqPV-H infection was associated with sex (<i>p</i> = 0.006) and performance (<i>p</i> = 0.049). In both EqPV-H-positive and control horses, liver-specific biochemical analytes were within the normal ranges. Phylogenetic analyses based on the partial sequences of EqPV-H NS1 revealed that the Korean EqPV-H isolates shared approximately 98.7–100% similarity. Of these, 11 Korean isolates shared high similarity with strains from the United States, Germany, and China, and the remaining three strains were distinct in phylogenetic analyses. The present study describes the current molecular prevalence, potential risk factors, and genetic diversity of Korean EqPV-H.
format	article
author	Sang-Kyu Lee Dongsun Park Inhyung Lee
author_facet	Sang-Kyu Lee Dongsun Park Inhyung Lee
author_sort	Sang-Kyu Lee
title	Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea
title_short	Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea
title_full	Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea
title_fullStr	Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea
title_full_unstemmed	Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea
title_sort	molecular prevalence of equine parvovirus-hepatitis in the sera of clinically healthy horses in south korea
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/55862ab412284206a8b3db10812aa73c
work_keys_str_mv	AT sangkyulee molecularprevalenceofequineparvovirushepatitisintheseraofclinicallyhealthyhorsesinsouthkorea AT dongsunpark molecularprevalenceofequineparvovirushepatitisintheseraofclinicallyhealthyhorsesinsouthkorea AT inhyunglee molecularprevalenceofequineparvovirushepatitisintheseraofclinicallyhealthyhorsesinsouthkorea
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Molecular Prevalence of Equine Parvovirus-Hepatitis in the Sera of Clinically Healthy Horses in South Korea

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