Neonatal thyroxine activation modifies epigenetic programming of the liver

Whether thyroid hormones affect gene expression via DNA methylation is not well known. Here the authors show that type 2 deiodinase (D2) converts T4 to produce T3, which prevents DNA methylation of discrete areas in the neonatal liver. In the absence of D2, DNA methylation occurs and is associated w...

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Autores principales:	Tatiana L. Fonseca, Tzintzuni Garcia, Gustavo W. Fernandes, T. Murlidharan Nair, Antonio C. Bianco
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/5587b3ecf19b472a84494cfe82d8da0a
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spelling	oai:doaj.org-article:5587b3ecf19b472a84494cfe82d8da0a2021-12-02T16:17:59ZNeonatal thyroxine activation modifies epigenetic programming of the liver10.1038/s41467-021-24748-82041-1723https://doaj.org/article/5587b3ecf19b472a84494cfe82d8da0a2021-07-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-24748-8https://doaj.org/toc/2041-1723Whether thyroid hormones affect gene expression via DNA methylation is not well known. Here the authors show that type 2 deiodinase (D2) converts T4 to produce T3, which prevents DNA methylation of discrete areas in the neonatal liver. In the absence of D2, DNA methylation occurs and is associated with reduced chromatin accessibility in promoters and enhancers and affects gene expression.Tatiana L. FonsecaTzintzuni GarciaGustavo W. FernandesT. Murlidharan NairAntonio C. BiancoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Tatiana L. Fonseca Tzintzuni Garcia Gustavo W. Fernandes T. Murlidharan Nair Antonio C. Bianco Neonatal thyroxine activation modifies epigenetic programming of the liver
description	Whether thyroid hormones affect gene expression via DNA methylation is not well known. Here the authors show that type 2 deiodinase (D2) converts T4 to produce T3, which prevents DNA methylation of discrete areas in the neonatal liver. In the absence of D2, DNA methylation occurs and is associated with reduced chromatin accessibility in promoters and enhancers and affects gene expression.
format	article
author	Tatiana L. Fonseca Tzintzuni Garcia Gustavo W. Fernandes T. Murlidharan Nair Antonio C. Bianco
author_facet	Tatiana L. Fonseca Tzintzuni Garcia Gustavo W. Fernandes T. Murlidharan Nair Antonio C. Bianco
author_sort	Tatiana L. Fonseca
title	Neonatal thyroxine activation modifies epigenetic programming of the liver
title_short	Neonatal thyroxine activation modifies epigenetic programming of the liver
title_full	Neonatal thyroxine activation modifies epigenetic programming of the liver
title_fullStr	Neonatal thyroxine activation modifies epigenetic programming of the liver
title_full_unstemmed	Neonatal thyroxine activation modifies epigenetic programming of the liver
title_sort	neonatal thyroxine activation modifies epigenetic programming of the liver
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/5587b3ecf19b472a84494cfe82d8da0a
work_keys_str_mv	AT tatianalfonseca neonatalthyroxineactivationmodifiesepigeneticprogrammingoftheliver AT tzintzunigarcia neonatalthyroxineactivationmodifiesepigeneticprogrammingoftheliver AT gustavowfernandes neonatalthyroxineactivationmodifiesepigeneticprogrammingoftheliver AT tmurlidharannair neonatalthyroxineactivationmodifiesepigeneticprogrammingoftheliver AT antoniocbianco neonatalthyroxineactivationmodifiesepigeneticprogrammingoftheliver
_version_	1718384230375882752

Neonatal thyroxine activation modifies epigenetic programming of the liver

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