The ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer

Introduction. Prostate cancer (PCa) is the most frequent cancer diagnosis in men worldwide. Our ability to identify those men whose cancer will decrease their lifespan and/or quality of life remains poor. The ReIMAGINE Consortium has been established to improve PCa diagnosis.Materials and methods. M...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Aida Santaolalla, Tim Hulsen, Jenson Davis, Hashim U. Ahmed, Caroline M. Moore, Shonit Punwani, Gert Attard, Neil McCartan, Mark Emberton, Anthony Coolen, Mieke Van Hemelrijck
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	prostate cancer risk stratification artificial intelligence data warehouse database data management Electronic computers. Computer science QA75.5-76.95
Acceso en línea:	https://doaj.org/article/558a9d5bd1d349c78ec70ece4a74dcf3
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:558a9d5bd1d349c78ec70ece4a74dcf3
record_format	dspace
spelling	oai:doaj.org-article:558a9d5bd1d349c78ec70ece4a74dcf32021-11-16T17:37:04ZThe ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer2624-821210.3389/frai.2021.769582https://doaj.org/article/558a9d5bd1d349c78ec70ece4a74dcf32021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/frai.2021.769582/fullhttps://doaj.org/toc/2624-8212Introduction. Prostate cancer (PCa) is the most frequent cancer diagnosis in men worldwide. Our ability to identify those men whose cancer will decrease their lifespan and/or quality of life remains poor. The ReIMAGINE Consortium has been established to improve PCa diagnosis.Materials and methods. MRI will likely become the future cornerstone of the risk-stratification process for men at risk of early prostate cancer. We will, for the first time, be able to combine the underlying molecular changes in PCa with the state-of-the-art imaging. ReIMAGINE Screening invites men for MRI and PSA evaluation. ReIMAGINE Risk includes men at risk of prostate cancer based on MRI, and includes biomarker testing.Results. Baseline clinical information, genomics, blood, urine, fresh prostate tissue samples, digital pathology and radiomics data will be analysed. Data will be de-identified, stored with correlated mpMRI disease endotypes and linked with long term follow-up outcomes in an instance of the Philips Clinical Data Lake, consisting of cloud-based software. The ReIMAGINE platform includes application programming interfaces and a user interface that allows users to browse data, select cohorts, manage users and access rights, query data, and more. Connection to analytics tools such as Python allows statistical and stratification method pipelines to run profiling regression analyses. Discussion. The ReIMAGINE Multimodal Warehouse comprises a unique data source for PCa research, to improve risk stratification for PCa and inform clinical practice. The de-identified dataset characterized by clinical, imaging, genomics and digital pathology PCa patient phenotypes will be a valuable resource for the scientific and medical community.Aida SantaolallaTim HulsenJenson DavisHashim U. AhmedCaroline M. MooreShonit PunwaniGert AttardNeil McCartanMark EmbertonAnthony CoolenAnthony CoolenMieke Van HemelrijckFrontiers Media S.A.articleprostate cancerrisk stratificationartificial intelligencedata warehousedatabasedata managementElectronic computers. Computer scienceQA75.5-76.95ENFrontiers in Artificial Intelligence, Vol 4 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	prostate cancer risk stratification artificial intelligence data warehouse database data management Electronic computers. Computer science QA75.5-76.95
spellingShingle	prostate cancer risk stratification artificial intelligence data warehouse database data management Electronic computers. Computer science QA75.5-76.95 Aida Santaolalla Tim Hulsen Jenson Davis Hashim U. Ahmed Caroline M. Moore Shonit Punwani Gert Attard Neil McCartan Mark Emberton Anthony Coolen Anthony Coolen Mieke Van Hemelrijck The ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer
description	Introduction. Prostate cancer (PCa) is the most frequent cancer diagnosis in men worldwide. Our ability to identify those men whose cancer will decrease their lifespan and/or quality of life remains poor. The ReIMAGINE Consortium has been established to improve PCa diagnosis.Materials and methods. MRI will likely become the future cornerstone of the risk-stratification process for men at risk of early prostate cancer. We will, for the first time, be able to combine the underlying molecular changes in PCa with the state-of-the-art imaging. ReIMAGINE Screening invites men for MRI and PSA evaluation. ReIMAGINE Risk includes men at risk of prostate cancer based on MRI, and includes biomarker testing.Results. Baseline clinical information, genomics, blood, urine, fresh prostate tissue samples, digital pathology and radiomics data will be analysed. Data will be de-identified, stored with correlated mpMRI disease endotypes and linked with long term follow-up outcomes in an instance of the Philips Clinical Data Lake, consisting of cloud-based software. The ReIMAGINE platform includes application programming interfaces and a user interface that allows users to browse data, select cohorts, manage users and access rights, query data, and more. Connection to analytics tools such as Python allows statistical and stratification method pipelines to run profiling regression analyses. Discussion. The ReIMAGINE Multimodal Warehouse comprises a unique data source for PCa research, to improve risk stratification for PCa and inform clinical practice. The de-identified dataset characterized by clinical, imaging, genomics and digital pathology PCa patient phenotypes will be a valuable resource for the scientific and medical community.
format	article
author	Aida Santaolalla Tim Hulsen Jenson Davis Hashim U. Ahmed Caroline M. Moore Shonit Punwani Gert Attard Neil McCartan Mark Emberton Anthony Coolen Anthony Coolen Mieke Van Hemelrijck
author_facet	Aida Santaolalla Tim Hulsen Jenson Davis Hashim U. Ahmed Caroline M. Moore Shonit Punwani Gert Attard Neil McCartan Mark Emberton Anthony Coolen Anthony Coolen Mieke Van Hemelrijck
author_sort	Aida Santaolalla
title	The ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer
title_short	The ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer
title_full	The ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer
title_fullStr	The ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer
title_full_unstemmed	The ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer
title_sort	reimagine multimodal warehouse: using artificial intelligence for accurate risk stratification of prostate cancer
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/558a9d5bd1d349c78ec70ece4a74dcf3
work_keys_str_mv	AT aidasantaolalla thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT timhulsen thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT jensondavis thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT hashimuahmed thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT carolinemmoore thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT shonitpunwani thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT gertattard thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT neilmccartan thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT markemberton thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT anthonycoolen thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT anthonycoolen thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT miekevanhemelrijck thereimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT aidasantaolalla reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT timhulsen reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT jensondavis reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT hashimuahmed reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT carolinemmoore reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT shonitpunwani reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT gertattard reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT neilmccartan reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT markemberton reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT anthonycoolen reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT anthonycoolen reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer AT miekevanhemelrijck reimaginemultimodalwarehouseusingartificialintelligenceforaccurateriskstratificationofprostatecancer
_version_	1718426301903142912

The ReIMAGINE Multimodal Warehouse: Using Artificial Intelligence for Accurate Risk Stratification of Prostate Cancer

Ejemplares similares