GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS

Here, we present clinical and epidemiological analysis of 85 Russian cases of pulmonary tuberculosis caused by an extensively drug-resistant M. tuberculosis strains. As defined by spoligotyping, M. tuberculosis strains belonged to the following genetic families: Beijing — 81.2%, which significantly...

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Autores principales:	N. R. Vasilieva, A. A. Vyazovaya, V. Yu. Zhuravlev, N. S. Solovieva, I. V. Mokrousov, O. V. Narvskaya
Formato:	article
Lenguaje:	RU
Publicado:	Sankt-Peterburg : NIIÈM imeni Pastera 2016
Materias:	mycobacterium tuberculosis extensively drug-resistant spoligotyping beijing genotype clinical and epidemiological analysis Infectious and parasitic diseases RC109-216
Acceso en línea:	https://doaj.org/article/558b3c0453b2404eb9806635ed4407db
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spelling	oai:doaj.org-article:558b3c0453b2404eb9806635ed4407db2021-11-22T07:09:48ZGENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS2220-76192313-739810.15789/2220-7619-2016-2-179-183https://doaj.org/article/558b3c0453b2404eb9806635ed4407db2016-06-01T00:00:00Zhttps://www.iimmun.ru/iimm/article/view/404https://doaj.org/toc/2220-7619https://doaj.org/toc/2313-7398Here, we present clinical and epidemiological analysis of 85 Russian cases of pulmonary tuberculosis caused by an extensively drug-resistant M. tuberculosis strains. As defined by spoligotyping, M. tuberculosis strains belonged to the following genetic families: Beijing — 81.2%, which significantly exceeds the prevalence rate of this genotype (50%) in M. tuberculosis population across Russia; LAM — 14.1% and Ural — 4.7%. Among patients infected with Beijing strains prevailed alcohol and tobacco abused males; the main source of infection were family and penitentiary contacts. This group of patients has been characterized by a variety of clinical forms of lung disease with the prevalence of fibro-cavernous tuberculosis and a significant proportion of patients with interrupted treatment. Regardless of the M. tuberculosis strain genotype, the extensively drug-resistant pulmonary tuberculosis is characterized by severe course leading to the chronic disease with the relapses and poor response to anti-tuberculosis treatment, requiring repeated hospitalizations and surgical treatments.N. R. VasilievaA. A. VyazovayaV. Yu. ZhuravlevN. S. SolovievaI. V. MokrousovO. V. NarvskayaSankt-Peterburg : NIIÈM imeni Pasteraarticlemycobacterium tuberculosisextensively drug-resistantspoligotypingbeijing genotypeclinical and epidemiological analysisInfectious and parasitic diseasesRC109-216RUInfekciâ i Immunitet, Vol 6, Iss 2, Pp 179-183 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	mycobacterium tuberculosis extensively drug-resistant spoligotyping beijing genotype clinical and epidemiological analysis Infectious and parasitic diseases RC109-216
spellingShingle	mycobacterium tuberculosis extensively drug-resistant spoligotyping beijing genotype clinical and epidemiological analysis Infectious and parasitic diseases RC109-216 N. R. Vasilieva A. A. Vyazovaya V. Yu. Zhuravlev N. S. Solovieva I. V. Mokrousov O. V. Narvskaya GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS
description	Here, we present clinical and epidemiological analysis of 85 Russian cases of pulmonary tuberculosis caused by an extensively drug-resistant M. tuberculosis strains. As defined by spoligotyping, M. tuberculosis strains belonged to the following genetic families: Beijing — 81.2%, which significantly exceeds the prevalence rate of this genotype (50%) in M. tuberculosis population across Russia; LAM — 14.1% and Ural — 4.7%. Among patients infected with Beijing strains prevailed alcohol and tobacco abused males; the main source of infection were family and penitentiary contacts. This group of patients has been characterized by a variety of clinical forms of lung disease with the prevalence of fibro-cavernous tuberculosis and a significant proportion of patients with interrupted treatment. Regardless of the M. tuberculosis strain genotype, the extensively drug-resistant pulmonary tuberculosis is characterized by severe course leading to the chronic disease with the relapses and poor response to anti-tuberculosis treatment, requiring repeated hospitalizations and surgical treatments.
format	article
author	N. R. Vasilieva A. A. Vyazovaya V. Yu. Zhuravlev N. S. Solovieva I. V. Mokrousov O. V. Narvskaya
author_facet	N. R. Vasilieva A. A. Vyazovaya V. Yu. Zhuravlev N. S. Solovieva I. V. Mokrousov O. V. Narvskaya
author_sort	N. R. Vasilieva
title	GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS
title_short	GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS
title_full	GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS
title_fullStr	GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS
title_full_unstemmed	GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS
title_sort	genotypes of extensively drug-resistant mycobacterium tuberculosis strains: clinical and epidemiological features of pulmonary tuberculosis
publisher	Sankt-Peterburg : NIIÈM imeni Pastera
publishDate	2016
url	https://doaj.org/article/558b3c0453b2404eb9806635ed4407db
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GENOTYPES OF EXTENSIVELY DRUG-RESISTANT MYCOBACTERIUM TUBERCULOSIS STRAINS: CLINICAL AND EPIDEMIOLOGICAL FEATURES OF PULMONARY TUBERCULOSIS

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