The Roles of Gasdermin D in Coronavirus Infection and Evasion

Pyroptosis is lytic, programmed cell death and plays a critical role against microbial invasion, functioning as an innate immune effector mechanism. The pore-forming protein gasdermin D (GSDMD), a member of gasdermin family proteins, is a primary effector of pyroptosis. The cleavage of inflammasome-...

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Autores principales:	Xiang Liu, Shihao Ding, Pinghuang Liu
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	gasdermin D pyroptosis inflammasomes viruses coronaviruses Microbiology QR1-502
Acceso en línea:	https://doaj.org/article/558f4cd8169c427ab4c814f7393848a6
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spelling	oai:doaj.org-article:558f4cd8169c427ab4c814f7393848a62021-12-01T07:29:57ZThe Roles of Gasdermin D in Coronavirus Infection and Evasion1664-302X10.3389/fmicb.2021.784009https://doaj.org/article/558f4cd8169c427ab4c814f7393848a62021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fmicb.2021.784009/fullhttps://doaj.org/toc/1664-302XPyroptosis is lytic, programmed cell death and plays a critical role against microbial invasion, functioning as an innate immune effector mechanism. The pore-forming protein gasdermin D (GSDMD), a member of gasdermin family proteins, is a primary effector of pyroptosis. The cleavage of inflammasome-associated inflammatory caspases activates GSDMD to liberate the N-terminal effector domain from the C-terminal inhibitory domain and form pores in the cellular plasma membrane. Emerging evidence shows that the pore-forming activity of GSDMD beyond pyroptosis and modifies non-lytic cytosolic protein secretion in living cells and innate immunity. While the essential roles of GSDMD in bacterial infection and cancer have been widely investigated, the importance of GSDMD in virus infection, including coronaviruses, remains elusive. Here, we review the current literature regarding the activation and functions of GSDMD during virus infections. Last, we further discuss the roles of GSDMD and the therapeutic potential of targeting this GSDMD pore-forming activity in coronavirus diseases.Xiang LiuShihao DingPinghuang LiuFrontiers Media S.A.articlegasdermin DpyroptosisinflammasomesvirusescoronavirusesMicrobiologyQR1-502ENFrontiers in Microbiology, Vol 12 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	gasdermin D pyroptosis inflammasomes viruses coronaviruses Microbiology QR1-502
spellingShingle	gasdermin D pyroptosis inflammasomes viruses coronaviruses Microbiology QR1-502 Xiang Liu Shihao Ding Pinghuang Liu The Roles of Gasdermin D in Coronavirus Infection and Evasion
description	Pyroptosis is lytic, programmed cell death and plays a critical role against microbial invasion, functioning as an innate immune effector mechanism. The pore-forming protein gasdermin D (GSDMD), a member of gasdermin family proteins, is a primary effector of pyroptosis. The cleavage of inflammasome-associated inflammatory caspases activates GSDMD to liberate the N-terminal effector domain from the C-terminal inhibitory domain and form pores in the cellular plasma membrane. Emerging evidence shows that the pore-forming activity of GSDMD beyond pyroptosis and modifies non-lytic cytosolic protein secretion in living cells and innate immunity. While the essential roles of GSDMD in bacterial infection and cancer have been widely investigated, the importance of GSDMD in virus infection, including coronaviruses, remains elusive. Here, we review the current literature regarding the activation and functions of GSDMD during virus infections. Last, we further discuss the roles of GSDMD and the therapeutic potential of targeting this GSDMD pore-forming activity in coronavirus diseases.
format	article
author	Xiang Liu Shihao Ding Pinghuang Liu
author_facet	Xiang Liu Shihao Ding Pinghuang Liu
author_sort	Xiang Liu
title	The Roles of Gasdermin D in Coronavirus Infection and Evasion
title_short	The Roles of Gasdermin D in Coronavirus Infection and Evasion
title_full	The Roles of Gasdermin D in Coronavirus Infection and Evasion
title_fullStr	The Roles of Gasdermin D in Coronavirus Infection and Evasion
title_full_unstemmed	The Roles of Gasdermin D in Coronavirus Infection and Evasion
title_sort	roles of gasdermin d in coronavirus infection and evasion
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/558f4cd8169c427ab4c814f7393848a6
work_keys_str_mv	AT xiangliu therolesofgasdermindincoronavirusinfectionandevasion AT shihaoding therolesofgasdermindincoronavirusinfectionandevasion AT pinghuangliu therolesofgasdermindincoronavirusinfectionandevasion AT xiangliu rolesofgasdermindincoronavirusinfectionandevasion AT shihaoding rolesofgasdermindincoronavirusinfectionandevasion AT pinghuangliu rolesofgasdermindincoronavirusinfectionandevasion
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The Roles of Gasdermin D in Coronavirus Infection and Evasion

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