USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS

Ubiquitination has an important function in the regulation of antiviral immunity involving the signalling molecule MAVS. Here the authors investigate deubiquitinating enzymes and show USP18 regulates MAVS mediated antiviral signalling through modulating the ubiquitination of MAVS via promotion of in...

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Autores principales:	Jinxiu Hou, Lulu Han, Ze Zhao, Huiqing Liu, Lei Zhang, Chunhong Ma, Fan Yi, Bingyu Liu, Yi Zheng, Chengjiang Gao
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2021
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55913ebdaee8461bb5eb2e3bfac8cd04
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spelling	oai:doaj.org-article:55913ebdaee8461bb5eb2e3bfac8cd042021-12-02T15:45:30ZUSP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS10.1038/s41467-021-23219-42041-1723https://doaj.org/article/55913ebdaee8461bb5eb2e3bfac8cd042021-05-01T00:00:00Zhttps://doi.org/10.1038/s41467-021-23219-4https://doaj.org/toc/2041-1723Ubiquitination has an important function in the regulation of antiviral immunity involving the signalling molecule MAVS. Here the authors investigate deubiquitinating enzymes and show USP18 regulates MAVS mediated antiviral signalling through modulating the ubiquitination of MAVS via promotion of interaction between MAVS and TRIM31.Jinxiu HouLulu HanZe ZhaoHuiqing LiuLei ZhangChunhong MaFan YiBingyu LiuYi ZhengChengjiang GaoNature PortfolioarticleScienceQENNature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Jinxiu Hou Lulu Han Ze Zhao Huiqing Liu Lei Zhang Chunhong Ma Fan Yi Bingyu Liu Yi Zheng Chengjiang Gao USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
description	Ubiquitination has an important function in the regulation of antiviral immunity involving the signalling molecule MAVS. Here the authors investigate deubiquitinating enzymes and show USP18 regulates MAVS mediated antiviral signalling through modulating the ubiquitination of MAVS via promotion of interaction between MAVS and TRIM31.
format	article
author	Jinxiu Hou Lulu Han Ze Zhao Huiqing Liu Lei Zhang Chunhong Ma Fan Yi Bingyu Liu Yi Zheng Chengjiang Gao
author_facet	Jinxiu Hou Lulu Han Ze Zhao Huiqing Liu Lei Zhang Chunhong Ma Fan Yi Bingyu Liu Yi Zheng Chengjiang Gao
author_sort	Jinxiu Hou
title	USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
title_short	USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
title_full	USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
title_fullStr	USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
title_full_unstemmed	USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
title_sort	usp18 positively regulates innate antiviral immunity by promoting k63-linked polyubiquitination of mavs
publisher	Nature Portfolio
publishDate	2021
url	https://doaj.org/article/55913ebdaee8461bb5eb2e3bfac8cd04
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USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS

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