Polyfunctional hydrophilic antioxidants - from molecular design to practical application

The processes of lipid peroxidation are universal phenomena which to a greater or lesser degree always develops in membranous and lipoprotein complexes of living organisms. Arising alongside lipid peroxidation intensification, the oxidative stress is an important pathogenetic factor of wide range of...

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Autor principal:	N. V. Kandalintseva
Formato:	article
Lenguaje:	RU
Publicado:	Scientific Сentre for Family Health and Human Reproduction Problems 2016
Materias:	phenolic antioxidants water-soluble antioxidants polyfunctional antioxidants bioantioxidant free radical pathologies Science Q
Acceso en línea:	https://doaj.org/article/55935005d8d6491baff94f341c0647c5
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spelling	oai:doaj.org-article:55935005d8d6491baff94f341c0647c52021-11-23T06:14:34ZPolyfunctional hydrophilic antioxidants - from molecular design to practical application2541-94202587-959610.12737/article_590823a3efe379.56505609https://doaj.org/article/55935005d8d6491baff94f341c0647c52016-05-01T00:00:00Zhttps://www.actabiomedica.ru/jour/article/view/209https://doaj.org/toc/2541-9420https://doaj.org/toc/2587-9596The processes of lipid peroxidation are universal phenomena which to a greater or lesser degree always develops in membranous and lipoprotein complexes of living organisms. Arising alongside lipid peroxidation intensification, the oxidative stress is an important pathogenetic factor of wide range of pathoses and pathological disease development, such as widely spread cardiovascular, phlogistic, oncological and endocrine diseases. Natural and synthetic phenolic antioxidants effectively inhibit lipid peroxidation in vitro and in vivo and attract attention of specialists as means of disease and pathosis prevention and treatment connected to oxidative stress development. The majority of biologically active antioxidants have lipophilic properties while their hydrophilic analogues differ favorably by higher velocity of transportation, convenient dosing and injecting which make them irreplaceable for pathosis treatment. The promising character of creation of water-soluble antioxidants, simultaneously possessing antiradical and antiperoxide activities are justified in the review. It is demonstrated that specimens of hydrophilic sulphurous phenolic antioxidants have marked biological activity. Such compounds as S-[3-(hydroxyaryl]propyl]thiosulfates have bioantioxidant, cardioprotective, anti-inflammatory and anti-tumor properties and can be used for correction of pathological conditions associated with the development of oxidative stress. Prospectivity of the further research is determined by the necessity to develop acting medicine components for free-radical pathology therapy.N. V. KandalintsevaScientific Сentre for Family Health and Human Reproduction Problemsarticlephenolic antioxidantswater-soluble antioxidantspolyfunctional antioxidantsbioantioxidantfree radical pathologiesScienceQRUActa Biomedica Scientifica, Vol 1, Iss 3(2), Pp 150-154 (2016)
institution	DOAJ
collection	DOAJ
language	RU
topic	phenolic antioxidants water-soluble antioxidants polyfunctional antioxidants bioantioxidant free radical pathologies Science Q
spellingShingle	phenolic antioxidants water-soluble antioxidants polyfunctional antioxidants bioantioxidant free radical pathologies Science Q N. V. Kandalintseva Polyfunctional hydrophilic antioxidants - from molecular design to practical application
description	The processes of lipid peroxidation are universal phenomena which to a greater or lesser degree always develops in membranous and lipoprotein complexes of living organisms. Arising alongside lipid peroxidation intensification, the oxidative stress is an important pathogenetic factor of wide range of pathoses and pathological disease development, such as widely spread cardiovascular, phlogistic, oncological and endocrine diseases. Natural and synthetic phenolic antioxidants effectively inhibit lipid peroxidation in vitro and in vivo and attract attention of specialists as means of disease and pathosis prevention and treatment connected to oxidative stress development. The majority of biologically active antioxidants have lipophilic properties while their hydrophilic analogues differ favorably by higher velocity of transportation, convenient dosing and injecting which make them irreplaceable for pathosis treatment. The promising character of creation of water-soluble antioxidants, simultaneously possessing antiradical and antiperoxide activities are justified in the review. It is demonstrated that specimens of hydrophilic sulphurous phenolic antioxidants have marked biological activity. Such compounds as S-[3-(hydroxyaryl]propyl]thiosulfates have bioantioxidant, cardioprotective, anti-inflammatory and anti-tumor properties and can be used for correction of pathological conditions associated with the development of oxidative stress. Prospectivity of the further research is determined by the necessity to develop acting medicine components for free-radical pathology therapy.
format	article
author	N. V. Kandalintseva
author_facet	N. V. Kandalintseva
author_sort	N. V. Kandalintseva
title	Polyfunctional hydrophilic antioxidants - from molecular design to practical application
title_short	Polyfunctional hydrophilic antioxidants - from molecular design to practical application
title_full	Polyfunctional hydrophilic antioxidants - from molecular design to practical application
title_fullStr	Polyfunctional hydrophilic antioxidants - from molecular design to practical application
title_full_unstemmed	Polyfunctional hydrophilic antioxidants - from molecular design to practical application
title_sort	polyfunctional hydrophilic antioxidants - from molecular design to practical application
publisher	Scientific Сentre for Family Health and Human Reproduction Problems
publishDate	2016
url	https://doaj.org/article/55935005d8d6491baff94f341c0647c5
work_keys_str_mv	AT nvkandalintseva polyfunctionalhydrophilicantioxidantsfrommoleculardesigntopracticalapplication
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Polyfunctional hydrophilic antioxidants - from molecular design to practical application

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