HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression

The long-non-coding HOX transcript antisense intergenic RNA (HOTAIR) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic effects and signaling pathways modulated by HOTAIR in early-stage breast cancer progres...

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Autores principales:	Martin C. Abba, María Laura Fabre, Jaeho Lee, Pradeep Tatineni, Hyunsuk Kil, C. Marcelo Aldaz
Formato:	article
Lenguaje:	EN
Publicado:	Frontiers Media S.A. 2021
Materias:	HOTAIR lncRNA breast cancer DCIS proliferation invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
Acceso en línea:	https://doaj.org/article/5594fe79e39c4b5ba772736ca4a05dd7
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id	oai:doaj.org-article:5594fe79e39c4b5ba772736ca4a05dd7
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spelling	oai:doaj.org-article:5594fe79e39c4b5ba772736ca4a05dd72021-11-17T04:31:55ZHOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression2234-943X10.3389/fonc.2021.783211https://doaj.org/article/5594fe79e39c4b5ba772736ca4a05dd72021-11-01T00:00:00Zhttps://www.frontiersin.org/articles/10.3389/fonc.2021.783211/fullhttps://doaj.org/toc/2234-943XThe long-non-coding HOX transcript antisense intergenic RNA (HOTAIR) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic effects and signaling pathways modulated by HOTAIR in early-stage breast cancer progression. We determined that HOTAIR induces premalignant phenotypic changes by increasing cell proliferation, migration, invasion and in vivo growth in normal and DCIS breast cell lines. Transcriptomic studies (RNA-seq) identified the main signaling pathways modulated by HOTAIR which include bioprocesses related to epithelial to mesenchymal transition, cell migration, extracellular matrix remodeling and activation of several signaling pathways (HIF1A, AP1 and FGFR). Similar pathways were identified as activated in primary invasive breast carcinomas with HOTAIR over-expression. We conclude that HOTAIR over-expression behaves as a positive regulator of cell growth and migration both in normal and DCIS breast cells involved with early-stage breast cancer progression.Martin C. AbbaMaría Laura FabreJaeho LeePradeep TatineniHyunsuk KilC. Marcelo AldazFrontiers Media S.A.articleHOTAIRlncRNAbreast cancerDCISproliferationinvasionNeoplasms. Tumors. Oncology. Including cancer and carcinogensRC254-282ENFrontiers in Oncology, Vol 11 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	HOTAIR lncRNA breast cancer DCIS proliferation invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282
spellingShingle	HOTAIR lncRNA breast cancer DCIS proliferation invasion Neoplasms. Tumors. Oncology. Including cancer and carcinogens RC254-282 Martin C. Abba María Laura Fabre Jaeho Lee Pradeep Tatineni Hyunsuk Kil C. Marcelo Aldaz HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
description	The long-non-coding HOX transcript antisense intergenic RNA (HOTAIR) was identified as significantly upregulated in breast ductal carcinoma in situ (DCIS). The aim of this study was to characterize the phenotypic effects and signaling pathways modulated by HOTAIR in early-stage breast cancer progression. We determined that HOTAIR induces premalignant phenotypic changes by increasing cell proliferation, migration, invasion and in vivo growth in normal and DCIS breast cell lines. Transcriptomic studies (RNA-seq) identified the main signaling pathways modulated by HOTAIR which include bioprocesses related to epithelial to mesenchymal transition, cell migration, extracellular matrix remodeling and activation of several signaling pathways (HIF1A, AP1 and FGFR). Similar pathways were identified as activated in primary invasive breast carcinomas with HOTAIR over-expression. We conclude that HOTAIR over-expression behaves as a positive regulator of cell growth and migration both in normal and DCIS breast cells involved with early-stage breast cancer progression.
format	article
author	Martin C. Abba María Laura Fabre Jaeho Lee Pradeep Tatineni Hyunsuk Kil C. Marcelo Aldaz
author_facet	Martin C. Abba María Laura Fabre Jaeho Lee Pradeep Tatineni Hyunsuk Kil C. Marcelo Aldaz
author_sort	Martin C. Abba
title	HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title_short	HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title_full	HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title_fullStr	HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title_full_unstemmed	HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression
title_sort	hotair modulated pathways in early-stage breast cancer progression
publisher	Frontiers Media S.A.
publishDate	2021
url	https://doaj.org/article/5594fe79e39c4b5ba772736ca4a05dd7
work_keys_str_mv	AT martincabba hotairmodulatedpathwaysinearlystagebreastcancerprogression AT marialaurafabre hotairmodulatedpathwaysinearlystagebreastcancerprogression AT jaeholee hotairmodulatedpathwaysinearlystagebreastcancerprogression AT pradeeptatineni hotairmodulatedpathwaysinearlystagebreastcancerprogression AT hyunsukkil hotairmodulatedpathwaysinearlystagebreastcancerprogression AT cmarceloaldaz hotairmodulatedpathwaysinearlystagebreastcancerprogression
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HOTAIR Modulated Pathways in Early-Stage Breast Cancer Progression

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