Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair

Jiacan Su, Liehu Cao, Baoqing Yu, Shaojun Song, Xinwei Liu, Zhiwei Wang, Ming LiDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, ChinaAbstract: A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biolo...

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Autores principales:	Su J, Cao L, Yu B, Song S, Liu X, Wang Z, Li M
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2012
Materias:	Medicine (General) R5-920
Acceso en línea:	https://doaj.org/article/5595c29cc50449ff9f1c439980b7f297
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spelling	oai:doaj.org-article:5595c29cc50449ff9f1c439980b7f2972021-12-02T05:02:17ZComposite scaffolds of mesoporous bioactive glass and polyamide for bone repair1176-91141178-2013https://doaj.org/article/5595c29cc50449ff9f1c439980b7f2972012-05-01T00:00:00Zhttp://www.dovepress.com/composite-scaffolds-of-mesoporous-bioactive-glass-and-polyamide-for-bo-a9927https://doaj.org/toc/1176-9114https://doaj.org/toc/1178-2013Jiacan Su, Liehu Cao, Baoqing Yu, Shaojun Song, Xinwei Liu, Zhiwei Wang, Ming LiDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, ChinaAbstract: A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400&ndash;500 &micro;m, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.Keywords: mesoporous bioglass, polyamide, composite scaffolds, biocompatibility, bone repairSu JCao LYu BSong SLiu XWang ZLi MDove Medical PressarticleMedicine (General)R5-920ENInternational Journal of Nanomedicine, Vol 2012, Iss default, Pp 2547-2555 (2012)
institution	DOAJ
collection	DOAJ
language	EN
topic	Medicine (General) R5-920
spellingShingle	Medicine (General) R5-920 Su J Cao L Yu B Song S Liu X Wang Z Li M Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair
description	Jiacan Su, Liehu Cao, Baoqing Yu, Shaojun Song, Xinwei Liu, Zhiwei Wang, Ming LiDepartment of Orthopedics, Changhai Hospital, Second Military Medical University, Shanghai, ChinaAbstract: A bone-implanted porous scaffold of mesoporous bioglass/polyamide composite (m-BPC) was fabricated, and its biological properties were investigated. The results indicate that the m-BPC scaffold contained open and interconnected macropores ranging 400&ndash;500 &micro;m, and exhibited a porosity of 76%. The attachment ratio of MG-63 cells on m-BPC was higher than polyamide scaffolds at 4 hours, and the cells with normal phenotype extended well when cultured with m-BPC and polyamide scaffolds. When the m-BPC scaffolds were implanted into bone defects of rabbit thighbone, histological evaluation confirmed that the m-BPC scaffolds exhibited excellent biocompatibility and osteoconductivity, and more effective osteogenesis than the polyamide scaffolds in vivo. The results indicate that the m-BPC scaffolds improved the efficiency of new bone regeneration and, thus, have clinical potential for bone repair.Keywords: mesoporous bioglass, polyamide, composite scaffolds, biocompatibility, bone repair
format	article
author	Su J Cao L Yu B Song S Liu X Wang Z Li M
author_facet	Su J Cao L Yu B Song S Liu X Wang Z Li M
author_sort	Su J
title	Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair
title_short	Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair
title_full	Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair
title_fullStr	Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair
title_full_unstemmed	Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair
title_sort	composite scaffolds of mesoporous bioactive glass and polyamide for bone repair
publisher	Dove Medical Press
publishDate	2012
url	https://doaj.org/article/5595c29cc50449ff9f1c439980b7f297
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Composite scaffolds of mesoporous bioactive glass and polyamide for bone repair

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