Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers t...

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Autores principales:	Joana Gonçalves, Cláudia Nunes, Liliana Ferreira, Maria Margarida Cruz, Helena Oliveira, Verónica Bastos, Álvaro Mayoral, Qing Zhang, Paula Ferreira
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	magnetic nanoparticles magnetite fucoidan magnetic hyperthermia therapy biocompatibility Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/55987f89face4914988445383dc87784
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spelling	oai:doaj.org-article:55987f89face4914988445383dc877842021-11-25T18:31:00ZCoating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency10.3390/nano111129392079-4991https://doaj.org/article/55987f89face4914988445383dc877842021-11-01T00:00:00Zhttps://www.mdpi.com/2079-4991/11/11/2939https://doaj.org/toc/2079-4991Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m<sup>−1</sup> and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm<sup>2</sup>kg<sup>−1</sup>, respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.Joana GonçalvesCláudia NunesLiliana FerreiraMaria Margarida CruzHelena OliveiraVerónica BastosÁlvaro MayoralQing ZhangPaula FerreiraMDPI AGarticlemagnetic nanoparticlesmagnetitefucoidanmagnetic hyperthermia therapybiocompatibilityChemistryQD1-999ENNanomaterials, Vol 11, Iss 2939, p 2939 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	magnetic nanoparticles magnetite fucoidan magnetic hyperthermia therapy biocompatibility Chemistry QD1-999
spellingShingle	magnetic nanoparticles magnetite fucoidan magnetic hyperthermia therapy biocompatibility Chemistry QD1-999 Joana Gonçalves Cláudia Nunes Liliana Ferreira Maria Margarida Cruz Helena Oliveira Verónica Bastos Álvaro Mayoral Qing Zhang Paula Ferreira Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency
description	Magnetic nanoparticles (NP), such as magnetite, have been the subject of research for application in the biomedical field, especially in Magnetic Hyperthermia Therapy (MHT), a promising technique for cancer therapy. NP are often coated with different compounds such as natural or synthetic polymers to protect them from oxidation and enhance their colloidal electrostatic stability while maintaining their thermal efficiency. In this work, the synthesis and characterization of magnetite nanoparticles coated with fucoidan, a biopolymer with recognized biocompatibility and antitumoral activity, is reported. The potential application of NP in MHT was evaluated through the assessment of Specific Loss Power (SLP) under an electromagnetic field amplitude of 14.7 kA m<sup>−1</sup> and at 276 kHz. For fucoidan-coated NP, it was obtained SLP values of 100 and 156 W/g, corresponding to an Intrinsic Loss Power (ILP) of 1.7 and 2.6 nHm<sup>2</sup>kg<sup>−1</sup>, respectively. These values are, in general, higher than the ones reported in the literature for non-coated magnetite NP or coated with other polymers. Furthermore, in vitro assays showed that fucoidan and fucoidan-coated NP are biocompatible. The particle size (between ca. 6 to 12 nm), heating efficiency, and biocompatibility of fucoidan-coated magnetite NP meet the required criteria for MHT application.
format	article
author	Joana Gonçalves Cláudia Nunes Liliana Ferreira Maria Margarida Cruz Helena Oliveira Verónica Bastos Álvaro Mayoral Qing Zhang Paula Ferreira
author_facet	Joana Gonçalves Cláudia Nunes Liliana Ferreira Maria Margarida Cruz Helena Oliveira Verónica Bastos Álvaro Mayoral Qing Zhang Paula Ferreira
author_sort	Joana Gonçalves
title	Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency
title_short	Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency
title_full	Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency
title_fullStr	Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency
title_full_unstemmed	Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency
title_sort	coating of magnetite nanoparticles with fucoidan to enhance magnetic hyperthermia efficiency
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/55987f89face4914988445383dc87784
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Coating of Magnetite Nanoparticles with Fucoidan to Enhance Magnetic Hyperthermia Efficiency

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