Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study

Objective: To evaluate the diagnostic utility of salivary C-reactive protein (CRP) and its potential correlation with serum CRP levels in full-term neonates with late-onset sepsis (LOS). Methods: This cross-sectional study included 90 neonates assigned to three equal groups: culture proven LOS, clin...

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Autores principales:	Angie M.S. Tosson, Dina Koptan, Rabab Abdel Aal, Marwa Abd Elhady
Formato:	article
Lenguaje:	EN
Publicado:	Elsevier 2021
Materias:	Late-onset neonatal sepsis Highly sensitive serum CRP Salivary CRP Pediatrics RJ1-570
Acceso en línea:	https://doaj.org/article/559cbf2c380e4733855599b1f4e3d121
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spelling	oai:doaj.org-article:559cbf2c380e4733855599b1f4e3d1212021-11-06T04:12:44ZEvaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study0021-755710.1016/j.jped.2021.01.004https://doaj.org/article/559cbf2c380e4733855599b1f4e3d1212021-11-01T00:00:00Zhttp://www.sciencedirect.com/science/article/pii/S0021755721000292https://doaj.org/toc/0021-7557Objective: To evaluate the diagnostic utility of salivary C-reactive protein (CRP) and its potential correlation with serum CRP levels in full-term neonates with late-onset sepsis (LOS). Methods: This cross-sectional study included 90 neonates assigned to three equal groups: culture proven LOS, clinical LOS and a control group. Clinical findings and routine laboratory data including complete blood pictures and blood culture results were documented. Highly sensitive serum CRP was measured according to hospital protocol, while salivary CRP levels were measured using enzyme-linked immunosorbent assay. Results: The median serum CRP was significantly higher in septic neonates compared to controls (p < 0.001). For serum CRP, the optimum cut-off value for LOS diagnosis was found to be 7.2 mg/L with sensitivity, specificity, positive and negative predictive values of 91, 100, 100, and 85.7%, respectively. No significant difference was observed in levels of salivary CRP among the 3 study groups (p = 0.39). No correlation was found between the levels of salivary and serum CRP (r = 0.074, p = 0.49). Conclusion: Serum CRP, at a cut-off value of 7.2 mg/L, exhibited a high specificity and positive predictive value in LOS diagnosis, whereas salivary CRP levels weren’t significantly different between the 3 study groups nor did they predict abnormal serum CRP thresholds in newborns with sepsis.Angie M.S. TossonDina KoptanRabab Abdel AalMarwa Abd ElhadyElsevierarticleLate-onset neonatal sepsisHighly sensitive serum CRPSalivary CRPPediatricsRJ1-570ENJornal de Pediatria, Vol 97, Iss 6, Pp 623-628 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	Late-onset neonatal sepsis Highly sensitive serum CRP Salivary CRP Pediatrics RJ1-570
spellingShingle	Late-onset neonatal sepsis Highly sensitive serum CRP Salivary CRP Pediatrics RJ1-570 Angie M.S. Tosson Dina Koptan Rabab Abdel Aal Marwa Abd Elhady Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study
description	Objective: To evaluate the diagnostic utility of salivary C-reactive protein (CRP) and its potential correlation with serum CRP levels in full-term neonates with late-onset sepsis (LOS). Methods: This cross-sectional study included 90 neonates assigned to three equal groups: culture proven LOS, clinical LOS and a control group. Clinical findings and routine laboratory data including complete blood pictures and blood culture results were documented. Highly sensitive serum CRP was measured according to hospital protocol, while salivary CRP levels were measured using enzyme-linked immunosorbent assay. Results: The median serum CRP was significantly higher in septic neonates compared to controls (p < 0.001). For serum CRP, the optimum cut-off value for LOS diagnosis was found to be 7.2 mg/L with sensitivity, specificity, positive and negative predictive values of 91, 100, 100, and 85.7%, respectively. No significant difference was observed in levels of salivary CRP among the 3 study groups (p = 0.39). No correlation was found between the levels of salivary and serum CRP (r = 0.074, p = 0.49). Conclusion: Serum CRP, at a cut-off value of 7.2 mg/L, exhibited a high specificity and positive predictive value in LOS diagnosis, whereas salivary CRP levels weren’t significantly different between the 3 study groups nor did they predict abnormal serum CRP thresholds in newborns with sepsis.
format	article
author	Angie M.S. Tosson Dina Koptan Rabab Abdel Aal Marwa Abd Elhady
author_facet	Angie M.S. Tosson Dina Koptan Rabab Abdel Aal Marwa Abd Elhady
author_sort	Angie M.S. Tosson
title	Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study
title_short	Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study
title_full	Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study
title_fullStr	Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study
title_full_unstemmed	Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study
title_sort	evaluation of serum and salivary c-reactive protein for diagnosis of late-onset neonatal sepsis: a single center cross-sectional study
publisher	Elsevier
publishDate	2021
url	https://doaj.org/article/559cbf2c380e4733855599b1f4e3d121
work_keys_str_mv	AT angiemstosson evaluationofserumandsalivarycreactiveproteinfordiagnosisoflateonsetneonatalsepsisasinglecentercrosssectionalstudy AT dinakoptan evaluationofserumandsalivarycreactiveproteinfordiagnosisoflateonsetneonatalsepsisasinglecentercrosssectionalstudy AT rabababdelaal evaluationofserumandsalivarycreactiveproteinfordiagnosisoflateonsetneonatalsepsisasinglecentercrosssectionalstudy AT marwaabdelhady evaluationofserumandsalivarycreactiveproteinfordiagnosisoflateonsetneonatalsepsisasinglecentercrosssectionalstudy
_version_	1718443916590579712

Evaluation of serum and salivary C-reactive protein for diagnosis of late-onset neonatal sepsis: A single center cross-sectional study

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