Heptapeptide Isolated from <i>Isochrysis zhanjiangensis</i> Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells

Marine microalgae can be used as sustainable protein sources in many fields with positive effects on human and animal health. DAPTMGY is a heptapeptide isolated from <i>Isochrysis zhanjiangensis</i> which is a microalga. In this study, we evaluated its anti-photoaging properties and mech...

Descripción completa

Guardado en:

Detalles Bibliográficos
Autores principales:	Zhaowan Zheng, Zhenbang Xiao, Yuan-Lin He, Yanfei Tang, Lefan Li, Chunxia Zhou, Pengzhi Hong, Hui Luo, Zhong-Ji Qian
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	heptapeptide photoaging UVB MMPs apoptosis Biology (General) QH301-705.5
Acceso en línea:	https://doaj.org/article/559d43c522d64fb7bb3e129604131d6f
Etiquetas:	Agregar Etiqueta Sin Etiquetas, Sea el primero en etiquetar este registro!

id	oai:doaj.org-article:559d43c522d64fb7bb3e129604131d6f
record_format	dspace
spelling	oai:doaj.org-article:559d43c522d64fb7bb3e129604131d6f2021-11-25T18:12:54ZHeptapeptide Isolated from <i>Isochrysis zhanjiangensis</i> Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells10.3390/md191106261660-3397https://doaj.org/article/559d43c522d64fb7bb3e129604131d6f2021-11-01T00:00:00Zhttps://www.mdpi.com/1660-3397/19/11/626https://doaj.org/toc/1660-3397Marine microalgae can be used as sustainable protein sources in many fields with positive effects on human and animal health. DAPTMGY is a heptapeptide isolated from <i>Isochrysis zhanjiangensis</i> which is a microalga. In this study, we evaluated its anti-photoaging properties and mechanism of action in human immortalized keratinocytes cells (HaCaT). The results showed that DAPTMGY scavenged reactive oxygen species (ROS) and increase the level of endogenous antioxidants. In addition, through the exploration of its mechanism, it was determined that DAPIMGY exerted anti-photoaging effects. Specifically, the heptapeptide inhibits UVB-induced apoptosis through down-regulation of p53, caspase-8, caspase-3 and Bax and up-regulation of Bcl-2. Thus, DAPTMGY, isolated from <i>I. zhanjiangensis</i>, exhibits protective effects against UVB-induced damage.Zhaowan ZhengZhenbang XiaoYuan-Lin HeYanfei TangLefan LiChunxia ZhouPengzhi HongHui LuoZhong-Ji QianMDPI AGarticleheptapeptidephotoagingUVBMMPsapoptosisBiology (General)QH301-705.5ENMarine Drugs, Vol 19, Iss 626, p 626 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	heptapeptide photoaging UVB MMPs apoptosis Biology (General) QH301-705.5
spellingShingle	heptapeptide photoaging UVB MMPs apoptosis Biology (General) QH301-705.5 Zhaowan Zheng Zhenbang Xiao Yuan-Lin He Yanfei Tang Lefan Li Chunxia Zhou Pengzhi Hong Hui Luo Zhong-Ji Qian Heptapeptide Isolated from <i>Isochrysis zhanjiangensis</i> Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells
description	Marine microalgae can be used as sustainable protein sources in many fields with positive effects on human and animal health. DAPTMGY is a heptapeptide isolated from <i>Isochrysis zhanjiangensis</i> which is a microalga. In this study, we evaluated its anti-photoaging properties and mechanism of action in human immortalized keratinocytes cells (HaCaT). The results showed that DAPTMGY scavenged reactive oxygen species (ROS) and increase the level of endogenous antioxidants. In addition, through the exploration of its mechanism, it was determined that DAPIMGY exerted anti-photoaging effects. Specifically, the heptapeptide inhibits UVB-induced apoptosis through down-regulation of p53, caspase-8, caspase-3 and Bax and up-regulation of Bcl-2. Thus, DAPTMGY, isolated from <i>I. zhanjiangensis</i>, exhibits protective effects against UVB-induced damage.
format	article
author	Zhaowan Zheng Zhenbang Xiao Yuan-Lin He Yanfei Tang Lefan Li Chunxia Zhou Pengzhi Hong Hui Luo Zhong-Ji Qian
author_facet	Zhaowan Zheng Zhenbang Xiao Yuan-Lin He Yanfei Tang Lefan Li Chunxia Zhou Pengzhi Hong Hui Luo Zhong-Ji Qian
author_sort	Zhaowan Zheng
title	Heptapeptide Isolated from <i>Isochrysis zhanjiangensis</i> Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells
title_short	Heptapeptide Isolated from <i>Isochrysis zhanjiangensis</i> Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells
title_full	Heptapeptide Isolated from <i>Isochrysis zhanjiangensis</i> Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells
title_fullStr	Heptapeptide Isolated from <i>Isochrysis zhanjiangensis</i> Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells
title_full_unstemmed	Heptapeptide Isolated from <i>Isochrysis zhanjiangensis</i> Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells
title_sort	heptapeptide isolated from <i>isochrysis zhanjiangensis</i> exhibited anti-photoaging potential via mapk/ap-1/mmp pathway and anti-apoptosis in uvb-irradiated hacat cells
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/559d43c522d64fb7bb3e129604131d6f
work_keys_str_mv	AT zhaowanzheng heptapeptideisolatedfromiisochrysiszhanjiangensisiexhibitedantiphotoagingpotentialviamapkap1mmppathwayandantiapoptosisinuvbirradiatedhacatcells AT zhenbangxiao heptapeptideisolatedfromiisochrysiszhanjiangensisiexhibitedantiphotoagingpotentialviamapkap1mmppathwayandantiapoptosisinuvbirradiatedhacatcells AT yuanlinhe heptapeptideisolatedfromiisochrysiszhanjiangensisiexhibitedantiphotoagingpotentialviamapkap1mmppathwayandantiapoptosisinuvbirradiatedhacatcells AT yanfeitang heptapeptideisolatedfromiisochrysiszhanjiangensisiexhibitedantiphotoagingpotentialviamapkap1mmppathwayandantiapoptosisinuvbirradiatedhacatcells AT lefanli heptapeptideisolatedfromiisochrysiszhanjiangensisiexhibitedantiphotoagingpotentialviamapkap1mmppathwayandantiapoptosisinuvbirradiatedhacatcells AT chunxiazhou heptapeptideisolatedfromiisochrysiszhanjiangensisiexhibitedantiphotoagingpotentialviamapkap1mmppathwayandantiapoptosisinuvbirradiatedhacatcells AT pengzhihong heptapeptideisolatedfromiisochrysiszhanjiangensisiexhibitedantiphotoagingpotentialviamapkap1mmppathwayandantiapoptosisinuvbirradiatedhacatcells AT huiluo heptapeptideisolatedfromiisochrysiszhanjiangensisiexhibitedantiphotoagingpotentialviamapkap1mmppathwayandantiapoptosisinuvbirradiatedhacatcells AT zhongjiqian heptapeptideisolatedfromiisochrysiszhanjiangensisiexhibitedantiphotoagingpotentialviamapkap1mmppathwayandantiapoptosisinuvbirradiatedhacatcells
_version_	1718411498002317312

Heptapeptide Isolated from <i>Isochrysis zhanjiangensis</i> Exhibited Anti-Photoaging Potential via MAPK/AP-1/MMP Pathway and Anti-Apoptosis in UVB-Irradiated HaCaT Cells

Ejemplares similares