Dipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. Possibilities of cardioprotection

Type 2 diabetes mellitus is a disease in which traditional therapeutic strategies, such as optimization of the lifestyle, intake of metformin and sulfonylureasor glitazone prove secondarily inefficient in the short run. The discovery and use of new hypoglycemic agents, e.g. DPP-4 inhibitors, openup...

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Autores principales:	Elena Nikolaevna Trunina, Nina Alexandrovna Petunina, Svetlana Alekseevna Chorbinskaya
Formato:	article
Lenguaje:	EN RU
Publicado:	Endocrinology Research Centre 2011
Materias:	dipeptidylpeptidase-4 inhibitors sitagliptin incretins glucagon-like peptide-1 cardiovascular system Nutritional diseases. Deficiency diseases RC620-627
Acceso en línea:	https://doaj.org/article/559ecd23d81f42339212c3a955980314
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id	oai:doaj.org-article:559ecd23d81f42339212c3a955980314
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spelling	oai:doaj.org-article:559ecd23d81f42339212c3a9559803142021-11-14T09:00:16ZDipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. Possibilities of cardioprotection2072-03512072-037810.14341/2072-0351-5636https://doaj.org/article/559ecd23d81f42339212c3a9559803142011-06-01T00:00:00Zhttps://www.dia-endojournals.ru/jour/article/view/5636https://doaj.org/toc/2072-0351https://doaj.org/toc/2072-0378Type 2 diabetes mellitus is a disease in which traditional therapeutic strategies, such as optimization of the lifestyle, intake of metformin and sulfonylureasor glitazone prove secondarily inefficient in the short run. The discovery and use of new hypoglycemic agents, e.g. DPP-4 inhibitors, openup opportunities for the further improvement of glycemic control. This review contains data on mechanisms of action, efficacy and safety of DPP-4inhibitors exemplified by sitagliptin and their possible effects on the cardiovascular system.Elena Nikolaevna TruninaNina Alexandrovna PetuninaSvetlana Alekseevna ChorbinskayaEndocrinology Research Centrearticledipeptidylpeptidase-4 inhibitorssitagliptinincretinsglucagon-like peptide-1cardiovascular systemNutritional diseases. Deficiency diseasesRC620-627ENRUСахарный диабет, Vol 14, Iss 2, Pp 59-64 (2011)
institution	DOAJ
collection	DOAJ
language	EN RU
topic	dipeptidylpeptidase-4 inhibitors sitagliptin incretins glucagon-like peptide-1 cardiovascular system Nutritional diseases. Deficiency diseases RC620-627
spellingShingle	dipeptidylpeptidase-4 inhibitors sitagliptin incretins glucagon-like peptide-1 cardiovascular system Nutritional diseases. Deficiency diseases RC620-627 Elena Nikolaevna Trunina Nina Alexandrovna Petunina Svetlana Alekseevna Chorbinskaya Dipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. Possibilities of cardioprotection
description	Type 2 diabetes mellitus is a disease in which traditional therapeutic strategies, such as optimization of the lifestyle, intake of metformin and sulfonylureasor glitazone prove secondarily inefficient in the short run. The discovery and use of new hypoglycemic agents, e.g. DPP-4 inhibitors, openup opportunities for the further improvement of glycemic control. This review contains data on mechanisms of action, efficacy and safety of DPP-4inhibitors exemplified by sitagliptin and their possible effects on the cardiovascular system.
format	article
author	Elena Nikolaevna Trunina Nina Alexandrovna Petunina Svetlana Alekseevna Chorbinskaya
author_facet	Elena Nikolaevna Trunina Nina Alexandrovna Petunina Svetlana Alekseevna Chorbinskaya
author_sort	Elena Nikolaevna Trunina
title	Dipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. Possibilities of cardioprotection
title_short	Dipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. Possibilities of cardioprotection
title_full	Dipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. Possibilities of cardioprotection
title_fullStr	Dipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. Possibilities of cardioprotection
title_full_unstemmed	Dipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. Possibilities of cardioprotection
title_sort	dipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. possibilities of cardioprotection
publisher	Endocrinology Research Centre
publishDate	2011
url	https://doaj.org/article/559ecd23d81f42339212c3a955980314
work_keys_str_mv	AT elenanikolaevnatrunina dipeptidylpeptidase4inhibitorsinthetreatmentofdiabetesmellituspossibilitiesofcardioprotection AT ninaalexandrovnapetunina dipeptidylpeptidase4inhibitorsinthetreatmentofdiabetesmellituspossibilitiesofcardioprotection AT svetlanaalekseevnachorbinskaya dipeptidylpeptidase4inhibitorsinthetreatmentofdiabetesmellituspossibilitiesofcardioprotection
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Dipeptidylpeptidase-4 inhibitors in the treatment of diabetes mellitus. Possibilities of cardioprotection

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