Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt

Maha Z Omar,1 Mohamed A Metwally,1 Hala M El-Feky,1 Inas A Ahmed,2,3 Mohamed A Ismail,4 Amal Idris2,3 1Department of Hepatology, Gastroenterology, and Infectious Diseases, 2Department of Medical Biochemistry, 3Molecular Biology and Biotechnology Unit, Benha University, Benha, 4Department of Hepatolo...

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Autores principales:	Omar MZ, Metwally MA, El-Feky HM, Ahmed IA, Ismail MA, Idris A
Formato:	article
Lenguaje:	EN
Publicado:	Dove Medical Press 2017
Materias:	Intrafamilial Transmission HCV Prevalence Egypt Diseases of the digestive system. Gastroenterology RC799-869
Acceso en línea:	https://doaj.org/article/55a68e05527940c384c6642f7f3a2155
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spelling	oai:doaj.org-article:55a68e05527940c384c6642f7f3a21552021-12-02T01:07:25ZRole of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt1179-1535https://doaj.org/article/55a68e05527940c384c6642f7f3a21552017-06-01T00:00:00Zhttps://www.dovepress.com/role-of-intrafamilial-transmission-in-high-prevalence-of-hepatitis-c-v-peer-reviewed-article-HMERhttps://doaj.org/toc/1179-1535Maha Z Omar,1 Mohamed A Metwally,1 Hala M El-Feky,1 Inas A Ahmed,2,3 Mohamed A Ismail,4 Amal Idris2,3 1Department of Hepatology, Gastroenterology, and Infectious Diseases, 2Department of Medical Biochemistry, 3Molecular Biology and Biotechnology Unit, Benha University, Benha, 4Department of Hepatology and Gastroenterology, Dekernes General Hospital, Dekernes, Egypt Background: Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Although an effective HCV treatment program has been adopted, it is estimated that the number of newly reported cases in Egypt is still high. Intrafamilial transmission may play a role in the high prevalence of HCV in Egypt. Identification of risk factors for the transmission of HCV may help in decreasing its prevalence and eliminating its infection. Aim: The aim of this study was to estimate the prevalence of HCV infection among the household contacts of HCV patients and identify the possible risk factors associated with intrafamilial transmission. Methods: This study was designed as a cohort study of 90 families of patients with confirmed chronic HCV and 38 families of non-HCV-infected persons. Diagnosis of HCV infection was performed by detection of HCV antibodies by fourth-generation enzyme-linked immunosorbent assay and confirmed by HCV RNA polymerase chain reaction. A pre-prepared questionnaire on risk factors was filled out by the participants. The prevalence of HCV was calculated, and univariate and multivariate analyses were carried out to identify the independent risk factors. Results: Among 90 positive-index families, 32 (35.6%) had contact persons with HCV infection compared to two of 38 (5.3%) negative-index families (P < 0.001, odds ratio [OR] = 9.9). Out of 257 index-positive contacts, 38 (14.8%) were infected compared to three of 75 (4%) of index-negative contacts (P = 0.01, OR = 4.3). Infection was associated with older age (6.9% of those aged <20 years, 10.4% of those aged 20–39 years, and 22% of those aged ≥40 years were infected) (P = 0.007). Husbands of infected wives were at a higher risk (33% infected) than wives (13.5%) and sons (16.9%) (P < 0.001). A history of hepatic encephalopathy was the independent predictor of intrafamilial transmission (P < 0.001, OR = 5.4). Conclusion: Intrafamilial transmission was found to possibly play a major role in the high prevalence of HCV in Egypt. Transmission was associated with older age and contact with patients with hepatic encephalopathy and was high among husbands of infected wives. Keywords: intrafamilial, transmission, HCV, prevalence, EgyptOmar MZMetwally MAEl-Feky HMAhmed IAIsmail MAIdris ADove Medical PressarticleIntrafamilialTransmissionHCVPrevalenceEgyptDiseases of the digestive system. GastroenterologyRC799-869ENHepatic Medicine: Evidence and Research, Vol Volume 9, Pp 27-33 (2017)
institution	DOAJ
collection	DOAJ
language	EN
topic	Intrafamilial Transmission HCV Prevalence Egypt Diseases of the digestive system. Gastroenterology RC799-869
spellingShingle	Intrafamilial Transmission HCV Prevalence Egypt Diseases of the digestive system. Gastroenterology RC799-869 Omar MZ Metwally MA El-Feky HM Ahmed IA Ismail MA Idris A Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt
description	Maha Z Omar,1 Mohamed A Metwally,1 Hala M El-Feky,1 Inas A Ahmed,2,3 Mohamed A Ismail,4 Amal Idris2,3 1Department of Hepatology, Gastroenterology, and Infectious Diseases, 2Department of Medical Biochemistry, 3Molecular Biology and Biotechnology Unit, Benha University, Benha, 4Department of Hepatology and Gastroenterology, Dekernes General Hospital, Dekernes, Egypt Background: Egypt has the highest prevalence of hepatitis C virus (HCV) worldwide. Although an effective HCV treatment program has been adopted, it is estimated that the number of newly reported cases in Egypt is still high. Intrafamilial transmission may play a role in the high prevalence of HCV in Egypt. Identification of risk factors for the transmission of HCV may help in decreasing its prevalence and eliminating its infection. Aim: The aim of this study was to estimate the prevalence of HCV infection among the household contacts of HCV patients and identify the possible risk factors associated with intrafamilial transmission. Methods: This study was designed as a cohort study of 90 families of patients with confirmed chronic HCV and 38 families of non-HCV-infected persons. Diagnosis of HCV infection was performed by detection of HCV antibodies by fourth-generation enzyme-linked immunosorbent assay and confirmed by HCV RNA polymerase chain reaction. A pre-prepared questionnaire on risk factors was filled out by the participants. The prevalence of HCV was calculated, and univariate and multivariate analyses were carried out to identify the independent risk factors. Results: Among 90 positive-index families, 32 (35.6%) had contact persons with HCV infection compared to two of 38 (5.3%) negative-index families (P < 0.001, odds ratio [OR] = 9.9). Out of 257 index-positive contacts, 38 (14.8%) were infected compared to three of 75 (4%) of index-negative contacts (P = 0.01, OR = 4.3). Infection was associated with older age (6.9% of those aged <20 years, 10.4% of those aged 20–39 years, and 22% of those aged ≥40 years were infected) (P = 0.007). Husbands of infected wives were at a higher risk (33% infected) than wives (13.5%) and sons (16.9%) (P < 0.001). A history of hepatic encephalopathy was the independent predictor of intrafamilial transmission (P < 0.001, OR = 5.4). Conclusion: Intrafamilial transmission was found to possibly play a major role in the high prevalence of HCV in Egypt. Transmission was associated with older age and contact with patients with hepatic encephalopathy and was high among husbands of infected wives. Keywords: intrafamilial, transmission, HCV, prevalence, Egypt
format	article
author	Omar MZ Metwally MA El-Feky HM Ahmed IA Ismail MA Idris A
author_facet	Omar MZ Metwally MA El-Feky HM Ahmed IA Ismail MA Idris A
author_sort	Omar MZ
title	Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt
title_short	Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt
title_full	Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt
title_fullStr	Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt
title_full_unstemmed	Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt
title_sort	role of intrafamilial transmission in high prevalence of hepatitis c virus in egypt
publisher	Dove Medical Press
publishDate	2017
url	https://doaj.org/article/55a68e05527940c384c6642f7f3a2155
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Role of intrafamilial transmission in high prevalence of hepatitis C virus in Egypt

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