Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis

Inflammation is a natural response to tissue injury. Uncontrolled inflammatory response leads to inflammatory disease. Acute pancreatitis is one of the main reasons for hospitalization amongst gastrointestinal disorders worldwide. It has been demonstrated that endogenous hydrogen sulfide (H<sub&g...

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Autores principales:	Ayush Kumar, Madhav Bhatia
Formato:	article
Lenguaje:	EN
Publicado:	MDPI AG 2021
Materias:	ICAM-1 VCAM-1 MAdCAM-1 VAP-1 Hyaluronan hydrogen sulfide Biology (General) QH301-705.5 Chemistry QD1-999
Acceso en línea:	https://doaj.org/article/55aa414b04d245e9aa628407bffad39a
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id	oai:doaj.org-article:55aa414b04d245e9aa628407bffad39a
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spelling	oai:doaj.org-article:55aa414b04d245e9aa628407bffad39a2021-11-25T17:53:42ZRole of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis10.3390/ijms2222121361422-00671661-6596https://doaj.org/article/55aa414b04d245e9aa628407bffad39a2021-11-01T00:00:00Zhttps://www.mdpi.com/1422-0067/22/22/12136https://doaj.org/toc/1661-6596https://doaj.org/toc/1422-0067Inflammation is a natural response to tissue injury. Uncontrolled inflammatory response leads to inflammatory disease. Acute pancreatitis is one of the main reasons for hospitalization amongst gastrointestinal disorders worldwide. It has been demonstrated that endogenous hydrogen sulfide (H<sub>2</sub>S), a gasotransmitter and substance P, a neuropeptide, are involved in the inflammatory process in acute pancreatitis. Cell adhesion molecules (CAM) are key players in inflammatory disease. Immunoglobulin (Ig) gene superfamily, selectins, and integrins are involved at different steps of leukocyte migration from blood to the site of injury. When the endothelial cells get activated, the CAMs are upregulated which leads to them interacting with leukocytes. This review summarizes our current understanding of the roles H<sub>2</sub>S, substance P and adhesion molecules play in acute pancreatitis.Ayush KumarMadhav BhatiaMDPI AGarticleICAM-1VCAM-1MAdCAM-1VAP-1Hyaluronanhydrogen sulfideBiology (General)QH301-705.5ChemistryQD1-999ENInternational Journal of Molecular Sciences, Vol 22, Iss 12136, p 12136 (2021)
institution	DOAJ
collection	DOAJ
language	EN
topic	ICAM-1 VCAM-1 MAdCAM-1 VAP-1 Hyaluronan hydrogen sulfide Biology (General) QH301-705.5 Chemistry QD1-999
spellingShingle	ICAM-1 VCAM-1 MAdCAM-1 VAP-1 Hyaluronan hydrogen sulfide Biology (General) QH301-705.5 Chemistry QD1-999 Ayush Kumar Madhav Bhatia Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis
description	Inflammation is a natural response to tissue injury. Uncontrolled inflammatory response leads to inflammatory disease. Acute pancreatitis is one of the main reasons for hospitalization amongst gastrointestinal disorders worldwide. It has been demonstrated that endogenous hydrogen sulfide (H<sub>2</sub>S), a gasotransmitter and substance P, a neuropeptide, are involved in the inflammatory process in acute pancreatitis. Cell adhesion molecules (CAM) are key players in inflammatory disease. Immunoglobulin (Ig) gene superfamily, selectins, and integrins are involved at different steps of leukocyte migration from blood to the site of injury. When the endothelial cells get activated, the CAMs are upregulated which leads to them interacting with leukocytes. This review summarizes our current understanding of the roles H<sub>2</sub>S, substance P and adhesion molecules play in acute pancreatitis.
format	article
author	Ayush Kumar Madhav Bhatia
author_facet	Ayush Kumar Madhav Bhatia
author_sort	Ayush Kumar
title	Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis
title_short	Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis
title_full	Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis
title_fullStr	Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis
title_full_unstemmed	Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis
title_sort	role of hydrogen sulfide, substance p and adhesion molecules in acute pancreatitis
publisher	MDPI AG
publishDate	2021
url	https://doaj.org/article/55aa414b04d245e9aa628407bffad39a
work_keys_str_mv	AT ayushkumar roleofhydrogensulfidesubstancepandadhesionmoleculesinacutepancreatitis AT madhavbhatia roleofhydrogensulfidesubstancepandadhesionmoleculesinacutepancreatitis
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Role of Hydrogen Sulfide, Substance P and Adhesion Molecules in Acute Pancreatitis

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