Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

Vitamin D is a precursor of the steroid hormone 1,25-dihydroxyvitamin D3, and its deficiency is associated with many adverse health outcomes. Here, Revez et al. perform a genome-wide association study for circulating 25-hydroxyvitamin D in 417,580 individuals and test for potential causal relationsh...

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Autores principales:	Joana A. Revez, Tian Lin, Zhen Qiao, Angli Xue, Yan Holtz, Zhihong Zhu, Jian Zeng, Huanwei Wang, Julia Sidorenko, Kathryn E. Kemper, Anna A. E. Vinkhuyzen, Julanne Frater, Darryl Eyles, Thomas H. J. Burne, Brittany Mitchell, Nicholas G. Martin, Gu Zhu, Peter M. Visscher, Jian Yang, Naomi R. Wray, John J. McGrath
Formato:	article
Lenguaje:	EN
Publicado:	Nature Portfolio 2020
Materias:	Science Q
Acceso en línea:	https://doaj.org/article/55add9b22a904d64a57de115f29178af
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spelling	oai:doaj.org-article:55add9b22a904d64a57de115f29178af2021-12-02T16:49:16ZGenome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration10.1038/s41467-020-15421-72041-1723https://doaj.org/article/55add9b22a904d64a57de115f29178af2020-04-01T00:00:00Zhttps://doi.org/10.1038/s41467-020-15421-7https://doaj.org/toc/2041-1723Vitamin D is a precursor of the steroid hormone 1,25-dihydroxyvitamin D3, and its deficiency is associated with many adverse health outcomes. Here, Revez et al. perform a genome-wide association study for circulating 25-hydroxyvitamin D in 417,580 individuals and test for potential causal relationships with other traits using Mendelian randomization.Joana A. RevezTian LinZhen QiaoAngli XueYan HoltzZhihong ZhuJian ZengHuanwei WangJulia SidorenkoKathryn E. KemperAnna A. E. VinkhuyzenJulanne FraterDarryl EylesThomas H. J. BurneBrittany MitchellNicholas G. MartinGu ZhuPeter M. VisscherJian YangNaomi R. WrayJohn J. McGrathNature PortfolioarticleScienceQENNature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
institution	DOAJ
collection	DOAJ
language	EN
topic	Science Q
spellingShingle	Science Q Joana A. Revez Tian Lin Zhen Qiao Angli Xue Yan Holtz Zhihong Zhu Jian Zeng Huanwei Wang Julia Sidorenko Kathryn E. Kemper Anna A. E. Vinkhuyzen Julanne Frater Darryl Eyles Thomas H. J. Burne Brittany Mitchell Nicholas G. Martin Gu Zhu Peter M. Visscher Jian Yang Naomi R. Wray John J. McGrath Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
description	Vitamin D is a precursor of the steroid hormone 1,25-dihydroxyvitamin D3, and its deficiency is associated with many adverse health outcomes. Here, Revez et al. perform a genome-wide association study for circulating 25-hydroxyvitamin D in 417,580 individuals and test for potential causal relationships with other traits using Mendelian randomization.
format	article
author	Joana A. Revez Tian Lin Zhen Qiao Angli Xue Yan Holtz Zhihong Zhu Jian Zeng Huanwei Wang Julia Sidorenko Kathryn E. Kemper Anna A. E. Vinkhuyzen Julanne Frater Darryl Eyles Thomas H. J. Burne Brittany Mitchell Nicholas G. Martin Gu Zhu Peter M. Visscher Jian Yang Naomi R. Wray John J. McGrath
author_facet	Joana A. Revez Tian Lin Zhen Qiao Angli Xue Yan Holtz Zhihong Zhu Jian Zeng Huanwei Wang Julia Sidorenko Kathryn E. Kemper Anna A. E. Vinkhuyzen Julanne Frater Darryl Eyles Thomas H. J. Burne Brittany Mitchell Nicholas G. Martin Gu Zhu Peter M. Visscher Jian Yang Naomi R. Wray John J. McGrath
author_sort	Joana A. Revez
title	Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
title_short	Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
title_full	Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
title_fullStr	Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
title_full_unstemmed	Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration
title_sort	genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin d concentration
publisher	Nature Portfolio
publishDate	2020
url	https://doaj.org/article/55add9b22a904d64a57de115f29178af
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Genome-wide association study identifies 143 loci associated with 25 hydroxyvitamin D concentration

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